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Developmental Consequences of Programmed Cell Death in Human Preimplantation Embryos

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Cell Death in Reproductive Physiology

Part of the book series: Proceedings in the Serono Symposia USA Series ((SERONOSYMP))

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Abstract

For many couples the failure to achieve and maintain pregnancy remains a major problem. An alternative solution for these couples is in-vitro fertilization (IVF). When the first IVF baby was born, no one expected that this unconventional method of conception would become such a widely used treatment for infertility. From the report of clinical results of assisted reproductive technology procedures in the USA and Canada for 1991, it is clear that of the 21,083 oocyte retrievals, 87.1% led to a successful fertilization and preembryo transfer. However, only 4,017 clinical pregnancies (19.1%) were achieved (1). The overall birth rate per IVF retrieval does not exceed 15.25%.

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Authors
  1. Andrea Jurisicova
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  2. Sussanah L. Varmuza
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  3. Robert F. Casper
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Editor information

Editors and Affiliations

  1. Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, 02114, USA

    Jonathan L. Tilly Ph.D.

  2. Center for Research on Reproduction and Women’s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Jerome F. Strauss III M.D., Ph.D.

  3. W. Alton Jones Cell Science Center, Lake Placid, NY, 12946, USA

    Martin Tenniswood Ph.D.

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© 1997 Springer Science+Business Media New York

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Jurisicova, A., Varmuza, S.L., Casper, R.F. (1997). Developmental Consequences of Programmed Cell Death in Human Preimplantation Embryos. In: Tilly, J.L., Strauss, J.F., Tenniswood, M. (eds) Cell Death in Reproductive Physiology. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1944-6_4

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  • DOI: https://doi.org/10.1007/978-1-4612-1944-6_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7351-6

  • Online ISBN: 978-1-4612-1944-6

  • eBook Packages: Springer Book Archive

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