Approximately four million people in the world die each year from cancer, which accounts for 10% to 20% of deaths from all causes.1 It is estimated that 50% to 60% of all patients with a terminal illness will have significant pain.2–4 Of these patients with pain, as many as 10% will have cancer pain that is considered intractable or refractory to medical management because of intolerable side effects with systemic medications and/or sedation causing significantly lowered mental status.5 The pain in these terminally ill patients is a direct result of the tumor in 65% to 75%, associated with or a result of the cancer therapy in 20% to 30% and unrelated to either in 5% to 10%.6,7 The etiology (ie, tumor, cancer therapy, or unrelated to either of these two causes) of the pain will greatly influence the choice and the efficacy of pain treatment options.
KeywordsPhenol Corticosteroid Morphine Oncol Stratification
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