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Fibroblast Growth Factor Receptors

  • Chapter
Growth Factors and Wound Healing

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Fibroblast growth factor (FGF) was discovered in the 1970s as an activity that stimulates the proliferation of 3T3 cells (1). Currently, FGFs comprise a family of nine structurally related proteins (FGF-1 to -9) (reviewed in 2–6). FGFs are expressed in specific spatial and temporal patterns and are involved in developmental processes, angiogenesis, wound healing, and tumorigenesis (3, 4, 7). The purification of basic FGF (FGF-2) and other related growth factors has been facilitated by the discovery that FGFs have a high affinity for heparin (2). These growth factors can be assayed on a variety of cells or embryos, in vitro, resulting in growth, survival, or differentiation (8–11).

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Authors
  1. David M. Ornitz
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  2. Gabriel Waksman
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Editor information

Editors and Affiliations

  1. Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Thomas R. Ziegler M.D.

  2. Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, CA, 92121, USA

    Glenn F. Pierce Ph.D., M.D.

  3. Shriners Burns Institute, The University of Texas Medical Branch, Galveston, TX, 77550, USA

    David N. Herndon M.D.

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© 1997 Springer Science+Business Media New York

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Ornitz, D.M., Waksman, G. (1997). Fibroblast Growth Factor Receptors. In: Ziegler, T.R., Pierce, G.F., Herndon, D.N. (eds) Growth Factors and Wound Healing. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1876-0_9

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  • DOI: https://doi.org/10.1007/978-1-4612-1876-0_9

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