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Roles of Keratinocyte Growth Factor in Epithelial Growth and Regeneration

  • Chapter
Book cover Growth Factors and Wound Healing

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

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Abstract

Keratinocyte growth factor (KGF) is a cytokine that was first identified in 1989 as a mesenchymally derived paracrine mediator of epithelial cell growth (1–3). Upon sequencing, approximately 35% to 40% homology was found with other members of the fibroblast growth factor (FGF) family; hence, KGF is designated as FGF7. In contrast to many other members of the FGF family, cells responsive to KGF appear to be confined to epithelial lineages (4). The KGF receptor (KGFR) is an alternatively spliced tyrosine kinase product of the FGF receptor 2 gene (FGFR2, bek) (5, 6). KGF and acidic FGF (FGF1) bind with high affinity to KGFR, while basic FGF (FGF2) binds with lower affinity (7, 8). The basis for a more KGF selective binding to the KGFR is found in a 49 amino acid stretch beginning in the C-terminal half of the third immunoglobulin loop in FGFR2 (9). A synthetic peptide from this region can block KGF interaction with the KGFR, demonstrating the specificity for KGF conferred by the alternative splicing event (10). Further work suggests elements of the second 1 g loop are also important for high-affinity binding to KGF (11). In contrast to acidic and basic FGF, KGF has a signal sequence and is secreted from mesenchymal cells in a conventional manner.

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Authors
  1. Sharon Lea Aukerman
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  2. Jeffrey S. Rubin
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  3. Glenn F. Pierce
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Editor information

Editors and Affiliations

  1. Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Thomas R. Ziegler M.D.

  2. Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, CA, 92121, USA

    Glenn F. Pierce Ph.D., M.D.

  3. Shriners Burns Institute, The University of Texas Medical Branch, Galveston, TX, 77550, USA

    David N. Herndon M.D.

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© 1997 Springer Science+Business Media New York

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Aukerman, S.L., Rubin, J.S., Pierce, G.F. (1997). Roles of Keratinocyte Growth Factor in Epithelial Growth and Regeneration. In: Ziegler, T.R., Pierce, G.F., Herndon, D.N. (eds) Growth Factors and Wound Healing. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1876-0_17

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  • DOI: https://doi.org/10.1007/978-1-4612-1876-0_17

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7321-9

  • Online ISBN: 978-1-4612-1876-0

  • eBook Packages: Springer Book Archive

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