Skip to main content
SpringerLink
Log in

Arginine and Nitric Oxide (NO) Interactions in the Healing Wound

  • Chapter
Growth Factors and Wound Healing

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

  • 354 Accesses

Abstract

The appearance, accumulation, degradation, and biologic activity of different cytokines at sites of injury and inflammation have attracted considerable attention. These signal peptides synthesized by inflammatory cells are justifiably thought to convey fundamental intercellular messages that regulate the process of repair.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albina JE, Shearer J, Mastrofrancesco B, Caldwell MD. Amino acid metabolism after X-carrageenan injury to rat skeletal muscle. Am J Physiol 1986;250:E24–30.

    PubMed  CAS  Google Scholar 

  2. Albina JE, Mills CD, Barbul A, et al. Arginine metabolism in wounds. Am J Physiol 1988;254:E459–67.

    PubMed  CAS  Google Scholar 

  3. Albina JE, Mills CD, Henry WL Jr, Caldwell MD. Temporal expression of different pathways of t-arginine metabolism in healing wounds. J Immunol 1990;144:3877–80.

    PubMed  CAS  Google Scholar 

  4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–42.

    PubMed  CAS  Google Scholar 

  5. Abate JA, Albina JE. Temporal expression of nitric oxide synthase in postendotoxin rat lung. In: Moncada S, Marletta MA, Hibbs JB Jr, Higgs EA, eds. The biology of nitric oxide. 2. Enzymology, biochemistry and immunology. Proceedings of the 2nd International Meeting on the Biology of Nitric Oxide; 1991 Sept. 30-Oct. 2; London. Colchester: Portland Press, 1992;197–9.

    Google Scholar 

  6. Hughes SR, Williams TJ, Brain SD. Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. Eur J Pharmacol 1990;191:481–4.

    Article  PubMed  CAS  Google Scholar 

  7. Ialenti A, Ianaro A, Moncada S, Di Rosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 1992;211:177–82.

    Article  PubMed  CAS  Google Scholar 

  8. Radomski MW, Palmer RMJ, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990;87:5193–7.

    Article  PubMed  CAS  Google Scholar 

  9. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651–5.

    Article  PubMed  CAS  Google Scholar 

  10. Kubes P, Kanwar S, Niu X-F, Gaboury JP. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J 1993; 7:1293–9.

    PubMed  CAS  Google Scholar 

  11. Kurose I, Kubes P, Wolf R, et al Inhibition of nitric oxide production: mechanisms of vascular albumin leakage. Circ Res 1993;73:164–71.

    Article  PubMed  CAS  Google Scholar 

  12. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620–4.

    Article  PubMed  CAS  Google Scholar 

  13. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J Biol Chem 1991;266:4244–50.

    PubMed  CAS  Google Scholar 

  14. Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J 1992;281:419–24.

    PubMed  CAS  Google Scholar 

  15. Beckman JS, Chen J, Ischiropoulos H, Crow JP. Oxidative chemistry of peroxynitrite. Methods Enzymol 1994;233:229–40.

    Article  PubMed  CAS  Google Scholar 

  16. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 1995;268:L699–722.

    PubMed  CAS  Google Scholar 

  17. Edlbacher S, Merz KW. Über den stoffwechsel der tumoren. Z Physiol Chem 1927;171:252–63.

    Article  CAS  Google Scholar 

  18. Schneider E, Dy M. The role of arginase in the immune response. Immunol Today 1985;6:136–40.

    Article  CAS  Google Scholar 

  19. Hunt TK. Prospective: a retrospective perspective on the nature of wounds. In: Barbul A, Pines E, Caldwell M, Hunt TK, eds. Growth factors and other aspects of wound healing. Biological and clinical implications. Proceedings of the Second International Symposium on Tissue Repair; 1987 May 13–17; Tarpon Springs (FL). New York: Alan R. Liss, 1987:xiii–xx.

    Google Scholar 

  20. Kershenobich D, Fierro FJ, Rojkind M. The relationship between the free pool of proline and collagen content in human liver cirrhosis. J Clin Invest 1970;49:2246–9.

    Article  PubMed  CAS  Google Scholar 

  21. Rojkind M, Diaz de León L. Collagen biosynthesis in cirrhotic rat liver slices: a regulatory mechanism. Biochim Biophys Acta 1970;217:512–22.

    Article  PubMed  CAS  Google Scholar 

  22. Albina JE, Abate JA, Mastrofrancesco B. Role of ornithine as a proline precursor in healing wounds. J Surg Res 1993;55:97–102.

    Article  PubMed  CAS  Google Scholar 

  23. Albina JE, Henry WL Jr, Mastrofrancesco B, Martin BA, Reichner JS. Macrophage activation by culture in an anoxic environment. J Immunol 1995; in press.

    Google Scholar 

  24. Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 1983; 211:1283–5.

    Article  Google Scholar 

  25. Leibovich SJ, Polverini PJ, Shepard HM, Wiseman DM, Shively V, Nuseir N. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-a. Nature 1987;329:630–2.

    Article  PubMed  CAS  Google Scholar 

  26. Rogers NE, Ignarro LJ. Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem Biophys Res Commun 1992;189:242–9.

    Article  PubMed  CAS  Google Scholar 

  27. Griscavage JM, Fukuto JM, Komori Y, Ignarro LJ. Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. J Biol Chem 1994;269:21644–9.

    PubMed  CAS  Google Scholar 

  28. Albina JE, Caldwell MD, Henry WL Jr, Mills CD. Regulation of macrophage functions by L-arginine J Exp Med 1989;169:1021–9.

    CAS  Google Scholar 

  29. Albina JE, Mills CD, Henry WL Jr, Caldwell MD. Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway. J Immunol 1989;143:3641–6.

    PubMed  CAS  Google Scholar 

  30. Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol 1993;150:5080–5.

    PubMed  CAS  Google Scholar 

  31. Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med 1990;172:1599–607.

    Article  PubMed  CAS  Google Scholar 

  32. Hoffman RA, Langrehr JM, Billiar TR, Curran RD, Simmons RL. Alloantigeninduced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J Immunol 1990;145:2220–6.

    PubMed  CAS  Google Scholar 

  33. Albina JE, Henry WL Jr. Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway. J Surg Res 1991;50:403–9.

    Article  PubMed  CAS  Google Scholar 

  34. Albina JE, Abate JA, Henry WL Jr. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. J Immunol 1991;147:144–8.

    PubMed  CAS  Google Scholar 

  35. Albina JE, Henry WL Jr. Cytokine network regulating macrophage-mediated suppression through nitric oxide synthase products. In: Moncada S, Marietta MA, Hibbs JB Jr, Higgs EA, eds. The biology of nitric oxide. 2. Enzymology, biochemistry and immunology. Proceedings of the 2nd International Meeting on the Biology of Nitric Oxide; 1991 Sept. 30-Oct. 2; London. Colchester: Portland Press, 1992:210–3.

    Google Scholar 

Download references

Authors
  1. Jorge E. Albina
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Thomas R. Ziegler M.D.

  2. Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, CA, 92121, USA

    Glenn F. Pierce Ph.D., M.D.

  3. Shriners Burns Institute, The University of Texas Medical Branch, Galveston, TX, 77550, USA

    David N. Herndon M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Albina, J.E. (1997). Arginine and Nitric Oxide (NO) Interactions in the Healing Wound. In: Ziegler, T.R., Pierce, G.F., Herndon, D.N. (eds) Growth Factors and Wound Healing. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1876-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1876-0_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7321-9

  • Online ISBN: 978-1-4612-1876-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation