Inhibin and Activin as Paracrine Regulators of Gonadal Function: In Vitro Model Systems

  • Jennie P. Mather
  • Rong-Hao Li
  • David M. Phillips
  • Alison Moore
Part of the Serono Symposia USA book series (SERONOSYMP)


Inhibin and activin were first described as feedback inhibitors of pituitary function. However, a range of data now supports the hypothesis that these factors play a major role in the paracrine regulation of gonadal function (1, 2). Activin seems to act as a mitogen and morphogen during development. Both inhibin and activin, and their receptors and binding proteins, are also expressed during the normal cycling of the adult ovary (3) and testis. The exact response to these hormones, however, may vary with the developmental stage of the testis or ovary and the stage of the seminiferous or follicular cycle.


Granulosa Cell Sertoli Cell Leydig Cell Seminiferous Tubule Gonadal Function 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jennie P. Mather
  • Rong-Hao Li
  • David M. Phillips
  • Alison Moore

There are no affiliations available

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