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Regulation of Angiogenesis by TGF-β Superfamily

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Inhibin, Activin and Follistatin

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

The angiogenesis process is regulated by many growth factors and cytokines, including transforming growth factor-beta (TGF-β) (1–3). The TGF-β superfamily, which contains the TGF-β family, the activin family, and the bone morphogenetic protein (BMP) family (4), exerts various effects on vascular cells. The effects of TGF-β differ between in vitro and in vivo (1–3). In this study, to investigate the mechanisms of regulation of angiogenesis by TGF-β superfamily members, angiogenic activity in vivo and the effects on cultured endothelial cells in vitro of TGF-β 1 activin A, and BMP-2 were examined.

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References

  1. Risau W. Angiogenic growth factors. Prog Growth Factor Res 1990;2:71–9.

    Article  PubMed  CAS  Google Scholar 

  2. Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994;79:185–8.

    Article  PubMed  CAS  Google Scholar 

  3. Yang EY, Moses HL. Transforming growth factor β 1-induced changes in cell mi-gration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 1990;l11:731–41.

    Article  Google Scholar 

  4. Yamashita H, ten Dijke P, Heldin C-H, Miyazono K. Bone morphogenetic protein receptors. Bone 1996.

    Google Scholar 

  5. Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Res 1986;46:467–73.

    PubMed  CAS  Google Scholar 

  6. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Sakseta O, et al. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 1994;269:6271–4.

    PubMed  CAS  Google Scholar 

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Authors
  1. Hidetoshi Yamashita
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  2. Akira Shimizu
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  3. Mituyasu Kato
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  4. Hideki Nishitoh
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  5. Hidenori Ichijo
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  6. Kohei Miyazono
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology School of Medicine, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Toshihiro Aono M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Division of Enzyme Cytology Institute for Enzyme Research, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Hiromu Sugino Ph.D.

  3. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Wylie W. Vale Ph.D.

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© 1997 Springer Science+Business Media New York

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Yamashita, H., Shimizu, A., Kato, M., Nishitoh, H., Ichijo, H., Miyazono, K. (1997). Regulation of Angiogenesis by TGF-β Superfamily. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_34

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  • DOI: https://doi.org/10.1007/978-1-4612-1874-6_34

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7320-2

  • Online ISBN: 978-1-4612-1874-6

  • eBook Packages: Springer Book Archive

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