Abstract
Activin A, a member of the transforming growth factor- β family, is a homodimer of β A chain and is implicated in the regulation of reproductive endocrine function, erythroid differentiation, mesoderm induction of the Xenopus embryo, and negative cell growth of various cell types including gonadal cells and adrenal cells (1–4). Recently, activin A was independently isolated from cultured media of activated mouse macrophages (5, 6) and mouse bone marrow stromal cells (7) as a factor inhibiting the growth of plasmacytic cells including B-cell hybridoma cells and myeloma cells. The plasmacytic cell growth inhibitory activity of activin A has been shown to be mediated in part by inducing apoptotic cell death (5–8). However, the precise mechanism by which activin A exerts its negative growth effect remains to be elucidated.
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Yamato, K., Koseki, T., Ohguchi, M., Sugino, H., Nishihara, T. (1997). Induction of G1 Arrest by Activin A via Cooperative Modulation of Cyclin D2 and p21CIP1/WAF1 in Hybridoma Cells. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_29
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DOI: https://doi.org/10.1007/978-1-4612-1874-6_29
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