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Transgenic Approaches to Study the Functions of the Transforming Growth Factor-β Superfamily Members

  • Chapter
Inhibin, Activin and Follistatin

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

The tranforming growth factor-β (TGF-β)-related proteins belong to a large superfamily of secreted growth factors (1). New members of the family are still being discovered through homology-based techniques, and more than 25 mammalian members have been discovered (1–9). The in vivo functions of many of these new members are currently not known. Embryonic stem (ES) cell technology (10–12), a powerful genetic tool, has allowed the delineation of the essential function of some of these proteins and thus has opened up new avenues of research by uncovering unknown functions. With the increasing use of ES cell technology, many new mutant mouse strains have been generated and analyzed in which members of the TGF-β family, their receptors, or ligand-binding proteins have been rendered functionally inactive. This chapter focuses on those genes that have been recently “knocked out” (Table 22.1). As the signaling pathways for these proteins are studied in greater detail, the importance of this superfamily in reproduction, development, and oncogenesis will become increasingly clear.

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Authors
  1. Anthony L. Lau
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  2. Weinian Shou
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  3. Qiuxia Guo
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  4. Martin M. Matzuk
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology School of Medicine, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Toshihiro Aono M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Division of Enzyme Cytology Institute for Enzyme Research, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Hiromu Sugino Ph.D.

  3. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Wylie W. Vale Ph.D.

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© 1997 Springer Science+Business Media New York

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Lau, A.L., Shou, W., Guo, Q., Matzuk, M.M. (1997). Transgenic Approaches to Study the Functions of the Transforming Growth Factor-β Superfamily Members. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_22

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  • DOI: https://doi.org/10.1007/978-1-4612-1874-6_22

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7320-2

  • Online ISBN: 978-1-4612-1874-6

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