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Inhibin, Activin and Follistatin pp 104–117Cite as

Two-Site Immunoassay for Native Inhibin A

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Inhibin is a glycoprotein consisting of two dissimilar subunits, termed α and β, that are linked by disulfide bonds (1–4). There are two β-subunit types: β A and β B. The α-subunit binds to either a β A-subunit to form inhibin A or to a β B-subunit to form inhibin B. Details of the structure of inhibin emerged after the cloning of the genes that control the production of the inhibin subunits. Separate genes code for the precursors to the α-, β A-, and β B-subunits, and these proteins are subsequently cleaved at sites of paired basic amino acids to yield the 20-kDa α-subunit and the 15-kDa β-subunits (5–9). Activin is a β-subunit dimer and consists of inhibin β A- and β B-subunits that have been termed activin A, activin AB, and activin B (10–12).

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Authors
  1. Yoshihisa Hasegawa
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  2. Hiroo Madarame
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  3. Sintaro Yoshida
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  4. Hiroyuki Kaneko
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  5. Yumiko Abe
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  6. Hideki Mizunuma
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  7. Yoshito Ibuki
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology School of Medicine, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Toshihiro Aono M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Division of Enzyme Cytology Institute for Enzyme Research, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Hiromu Sugino Ph.D.

  3. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Wylie W. Vale Ph.D.

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© 1997 Springer Science+Business Media New York

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Hasegawa, Y. et al. (1997). Two-Site Immunoassay for Native Inhibin A. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_10

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  • DOI: https://doi.org/10.1007/978-1-4612-1874-6_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7320-2

  • Online ISBN: 978-1-4612-1874-6

  • eBook Packages: Springer Book Archive

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