Postsurgical Intraperitoneal Tissue Repair: Implication of TGF-β

  • Nasser Chegini


The peritoneal and serosal surfaces of organs within the peritoneal cavity are composed of mesothelial cells and submesothelial tissue that contains fibroblasts, macrophages, and blood vessels. Even with the most optimal surgical procedures, minor injuries to these surfaces cause an inflammatory response that leads to minor adhesion formations that are transient and are often absorbed within a few days, possibly by fibrinolytic mechanisms. 1–6 However, when the tissue trauma is extensive and spontaneous healing does not proceed correctly, permanent intraperitoneal adhesions may form between the peritoneum and the serosal surface of adjacent organs. These extensive adhesions are considered a pathologic state in which the continuous unity of the peritoneal wall or serosal surface of organs is destroyed, leading to impairment of their physiologic functions. Extensive fibrous adhesions are the major cause of postoperative complications such as intestinal obstruction, chronic pain, or infertility. Infertility secondary to adhesions affecting the uterus, fallopian tubes, or ovaries accounts for approximately 20% of all infertility.4


Ischemia Lactate Heparin Serine Polypeptide 


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© Springer Science+Business Media New York 1997

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  • Nasser Chegini

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