Skip to main content

Fertility Issues in the Patient with Testis Cancer

  • Chapter
Male Infertility and Sexual Dysfunction
  • 394 Accesses

Abstract

In the past 20 years a marked improvement in the outlook for men with testis cancer has been achieved, aided by advances in imaging technologies, which now can better diagnose the presence or absence of metastatic disease, and refinements in surgical and anesthetic techniques for excision of difficult, persistent metastatic lesions. The most marked change, however, has come from the development of effective chemotherapy for the treatment of metastatic lesions. In the 1990s, it is expected that >95% of men with low-volume metastatic testicular cancer will survive their neoplasm.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Horwich A, Norman A, Fisher C, et al. Primary chemotherapy for stage 11 nonseminomatous germ cell tumors of the testis. J Urol 1994; 151: 72–77.

    PubMed  CAS  Google Scholar 

  2. Nijman JM, Schraffordt-Koops H, Kremer J, et al. Fertility and hormonal function in patients with a nonseminomatous tumor of the testis. Arch Androl 1985; 14: 239–246.

    Article  PubMed  CAS  Google Scholar 

  3. Drasga RE, Einhorn LH, Williams SD, et al. Fertility after chemotherapy for testicular cancer. J Clin Oncol 1983; 1: 179–183.

    PubMed  CAS  Google Scholar 

  4. Hendry WF, Stedronska J, Jones CR, et al. Semen analysis in testicular cancer and Hodgkin’s disease: pre-and post-treatment findings and implications for cryopreservation. Br J Urol 1983; 55: 769–773.

    Article  PubMed  CAS  Google Scholar 

  5. Berthelsen JG. Sperm counts and serum follicle-stimulating hormone levels before and after radiotherapy and chemotherapy in men with testicular germ cell cancer. Fertil Steril 1984; 41: 281–286.

    PubMed  CAS  Google Scholar 

  6. Fossa SD, Abyholm T, Aakvaag A. Spermatogenesis and hormonal status after orchiectomy for cancer and before supplementary treatment. Eur Urol 1984; 10: 173–177.

    PubMed  CAS  Google Scholar 

  7. Bouchot O, Plougastel ML, Karam G, et al. [Sterility and tumors of the testis. Study of late exocrine and endocrine functions in stage I or IIA tumors]. J Urol (Paris) 1989; 95: 367371.

    Google Scholar 

  8. Fossa SD, Aabyholm T, Vespestad S, et al. Semen quality after treatment for testicular cancer. Eur Urol 1993; 23: 172–176.

    PubMed  CAS  Google Scholar 

  9. Ferreira U, Netto NRJ, Esteves SC, et al. Comparative study of the fertility potential of men with only one testis. Scand J Urol Nephrol 1991; 25: 255–259.

    Article  PubMed  CAS  Google Scholar 

  10. Fossa SD, Theodorsen L, Norman N, et al. Recovery of impaired pretreatment spermatogenesis in testicular cancer. Fertil Steril 1990; 54: 493–496.

    PubMed  CAS  Google Scholar 

  11. Foster RS, Rubin LR, McNulty A, et al. Detection of antisperm-antibodies in patients with primary testicular cancer. Int J Androl 1991; 14: 179–185.

    Article  PubMed  CAS  Google Scholar 

  12. Guazzieri S, Lembo A, Ferro G, et al. Sperm antibodies and infertility in patients with testicular cancer. Urology 1985; 26: 139–142.

    Article  PubMed  CAS  Google Scholar 

  13. Hobarth K, Klingler HC, Maier U, et al. Incidence of antisperm antibodies in patients with carcinoma of the testis and in subfertile men with normogonadotropic oligoasthenoteratozoospermia. Urol Int 1994; 52: 162–165.

    Article  PubMed  CAS  Google Scholar 

  14. Lefebvre H, Laquerriere A, Cleret JM, et al. A hCG-secreting testicular seminoma revealed by male infertility: mechanism of hCG-evoked en-docrine disturbances. Andrologia 1993; 25: 283–287.

    Article  PubMed  CAS  Google Scholar 

  15. Carroll PR, Whitmore WFJ, Herr HW, et al. Endocrine and exocrine profiles of men with testicular tumors before orchiectomy. J Urol 1987; 137: 420–423.

    PubMed  CAS  Google Scholar 

  16. Sharma RK, Tolentino MV, Thomas AJ, et al. Optimal dose and duration of exposure to artificial stimulants in cryopreserved human spermatozoa. J Urol 1996; 155: 568–573.

    Article  PubMed  CAS  Google Scholar 

  17. Chilvers C, Dudley NE, Gough MH, et al. Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg 1986; 21: 691–696.

    Article  PubMed  CAS  Google Scholar 

  18. Muller J, Skakkebaek NE, Nielsen OH, et al. Cryptorchidism and testis cancer. Atypical infantile germ cells followed by carcinoma in situ and invasive carcinoma in adulthood. Cancer 1984; 54: 629–634.

    Article  PubMed  CAS  Google Scholar 

  19. Muller J, Skakkebaek NE, Ritzen M, et al. Carcinoma in situ of the testis in children with 45,X/ 46,XY gonadal dysgenesis. J Pediatr 1985; 106: 431–446.

    Article  PubMed  CAS  Google Scholar 

  20. Andres TL, Trainer TD, Leadbetter GW. Atypical germ cells preceding metachronous bilateral testicular tumors. Urology 1980; 15: 307–309.

    Article  PubMed  CAS  Google Scholar 

  21. Daugaard G, Giwercman A, Skakkebaek NE. Should the other testis be biopsied? Semin Urol 1996; 14: 8–12.

    CAS  Google Scholar 

  22. Berthelsen JG, Skakkebaek NE. Gonadal function in men with testis cancer. Fertil Steril 1983; 39: 68–75.

    PubMed  CAS  Google Scholar 

  23. Pryor JP, Cameron KM, Chilton CP, et al. Carcinoma in situ in testicular biopsies from men presenting with infertility. Br J Urol 1983; 55: 780–784.

    Article  PubMed  CAS  Google Scholar 

  24. Skakkebaek NE. Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. Histopathology 1978; 2: 157–170.

    Article  PubMed  CAS  Google Scholar 

  25. Bettocchi C, Coker CB, Deacon J, et al. A review of testicular intratubular germ cell neoplasia in infertile men. J Androl 1994; 15: 14S - 16S.

    PubMed  Google Scholar 

  26. Nistal M, Codesal J, Paniagua R. Carcinoma in situ of the testis in infertile men. A histological, immunocytochemical, and cytophotometric study of DNA content. J Pathol 1989; 159: 205–210.

    Article  PubMed  CAS  Google Scholar 

  27. Giwercman A, Muller J, Skakkebaek NE. Prevalence of carcinoma in situ and other histopathological abnormalities in testes from 399 men who died suddenly and unexpectedly. J Urol 1991; 145: 77–80.

    PubMed  CAS  Google Scholar 

  28. Centola GM, Keller JW, Henzler M, et al. Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl 1994; 15: 608–613.

    PubMed  CAS  Google Scholar 

  29. Littley MD, Shalet SM, Morgenstern GR, et al. Endocrine and reproductive dysfunction following fractionated total body irradiation in adults. Q J Med 1991; 78: 265–274.

    PubMed  CAS  Google Scholar 

  30. Giwercman A, von der Maase H, Berthelsen JG, et al. Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients. J Clin Endocrinol Metab 1991; 73: 596–603.

    Article  PubMed  CAS  Google Scholar 

  31. Brennemann W, Brensing KA, Leipner N, et al. Attempted protection of spermatogenesis from irradiation in patients with seminoma by D- tryptophan-6 luteinizing hormone releasing hormone. Clin Invest 1994; 72: 838–842.

    Article  CAS  Google Scholar 

  32. Fossa SD, Abyholm T, Normann N, et al. Post-treatment fertility in patients with testicular cancer. III. Influence of radiotherapy in seminoma patients. Br J Urol 1986; 58: 315–319.

    Article  PubMed  CAS  Google Scholar 

  33. Bracken RB, Johnson DE. Sexual function and fecundity after treatment for testicular tumors. Urology 1976; 7: 35–38.

    Article  PubMed  CAS  Google Scholar 

  34. Malas S, Levin V, Sur RK, et al. Fertility in patients treated with radiotherapy following orchidectomy for testicular seminoma. Clin Oncol (R Coll Radiol) 1994; 6: 377–380.

    Article  CAS  Google Scholar 

  35. Fossa SD, Almaas B, Jetne V, et al. Paternity after irradiation for testicular cancer. Acta Radiol Oncol 1986; 25: 33–36.

    Article  PubMed  CAS  Google Scholar 

  36. Fossa SD, Ous S, Abyholm T, et al. Post-treatment fertility in patients with testicular cancer. II. Influence of cis-platin-based combination chemotherapy and of retroperitoneal surgery on hormone and sperm cell production. Br J Urol 1985; 57: 210–214.

    Article  PubMed  CAS  Google Scholar 

  37. Johnson DH, Hainsworth JD, Linde RB, et al. Testicular function following combination chemotherapy with cisplatin, vinblastine, and bleomycin. Med Pediatr Oncol 1984; 12: 233–238.

    Article  PubMed  CAS  Google Scholar 

  38. Kreuser ED, Harsch U, Hetzel WD, et al. Chronic gonadal toxicity in patients with testicular cancer after chemotherapy. Eur J Cancer Clin Oncol 1986; 22: 289–294.

    Article  PubMed  CAS  Google Scholar 

  39. Poirier S, Einhorn LH, Rubin L. Evaluation of reproductive capacity in germ cell tumor patients following chemotherapy with cisplatin, VP-16 and bleomycin (meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1992; A1313.

    Google Scholar 

  40. Fossa SD, Klepp O, Norman N. Lack of gonadal protection by medroxyprogesterone acetate-induced transient medical castration during chemotherapy for testicular cancer. Br J Urol 1988; 62: 449–453.

    Article  PubMed  CAS  Google Scholar 

  41. Kreuser ED, Klingmuller D, Thiel E. The role of LHRH-analogues in protecting gonadal functions during chemotherapy and irradiation. Eur Urol 1993; 23: 157–164.

    PubMed  CAS  Google Scholar 

  42. Krause W, Pfluger KH. Treatment with the gonadotropin-releasing hormone agonist buse-relin to protect spermatogenesis against cytotoxic treatment in young men. Andrologia 1989; 21: 265–270.

    Article  PubMed  CAS  Google Scholar 

  43. Kedia KR, Markland C, Fraley EE. Sexual function following high retroperitoneal lymphade-nectomy. J Urol 1975; 114: 237–239.

    PubMed  CAS  Google Scholar 

  44. Nijman JM, Schraffordt KH, Oldhoff J, et al. Sexual function after bilateral retroperitoneal lymph node dissection for nonseminomatous testicular cancer. Arch Androl 1987; 18: 255–267.

    Article  PubMed  CAS  Google Scholar 

  45. Lange PH, Narayan P, Fraley EE. Fertility issues following therapy for testicular cancer. Semin Urol 1984; 2: 264–274.

    PubMed  CAS  Google Scholar 

  46. Jewett MAS, Kong YS, Goldberg SD, et al. Retroperitoneal lymphadenectomy for testis tumor with nerve sparing for ejaculation./Urol 1988; 139: 1220–1224.

    CAS  Google Scholar 

  47. Donohue JP, Foster RS, Rowland RG, et al. Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation. J Urol 1990; 144: 287–291.

    PubMed  CAS  Google Scholar 

  48. Weidner W, Zoller G, Sauerwein D, et al. A modified technique for nerve-sparing retroperitoneal lymph node dissection in stage II nonseminomatous germ cell tumors using intraoperative measurement of bladder neck pressure alterations following sympathetic nerve fiber electrostimulation. Eur Urol 1994; 26: 67–70.

    PubMed  CAS  Google Scholar 

  49. Foster RS, Bennett R, Bihrle R, et al. A preliminary report: postoperative fertility assessment in nerve-sparing RPLND patients. Eur Urol 1993; 23: 165–167.

    PubMed  CAS  Google Scholar 

  50. Ogura K, Nakamura K, Matsuda T, et al. [Successful artificial insemination in a patient with retrograde ejaculation following retroperitoneal lymph node dissection for testicular cancer: a case report]. Hinyokika Kiyo 1993; 39: 373–376.

    PubMed  CAS  Google Scholar 

  51. Umekawa T, Kiwamoto H, Iguchi M, et al. [AIH in male infertility due to retrograde ejaculation after retroperitoneal lymph node dissection]. Nippon Hinyokika Gakkai Zasshi 1991; 82: 492–495.

    PubMed  CAS  Google Scholar 

  52. Narayan P, Lange PH, Fraley EE. Ejaculation and fertility after extended retroperitoneal lymph node dissection for testicular cancer. J Urol 1982; 127: 685–688.

    PubMed  CAS  Google Scholar 

  53. Brenner J, Vugrin D, Whitmore WFJ. Effect of treatment on fertility and sexual function in males with metastatic nonseminomatous germ cell tumors of testis. Am J Clin Oncol 1985; 8: 178–182.

    Article  PubMed  CAS  Google Scholar 

  54. Fossa SD, Ous S, Abyholm T, et al. Post-treatment fertility in patients with testicular cancer. I. Influence of retroperitoneal lymph node dissection on ejaculatory potency. Br J Urol 1985; 57: 204–209.

    Article  PubMed  CAS  Google Scholar 

  55. Ohl DA, Denil J, Bennett CJ, et al. Elec-troejaculation following retroperitoneal lymph-adenectomy. J Urol 1991; 145: 980–983.

    PubMed  CAS  Google Scholar 

  56. Fried P, Steinfeld R, Casileth B, et al. Incidence of developmental handicaps among the offspring of men treated for testicular seminoma. Int J Androl 1987; 10: 385–387.

    Article  PubMed  CAS  Google Scholar 

  57. Hansen PV, Glavind K, Panduro J, et al. Paternity in patients with testicular germ cell cancer: pretreatment and post-treatment findings. Eur J Cancer 1991; 27: 1385–1389.

    Article  PubMed  CAS  Google Scholar 

  58. Bracken RB, Smith KD. Is semen cryopres-ervation helpful in testicular cancer? Urology 1980; 15: 581–583.

    Article  PubMed  CAS  Google Scholar 

  59. Sanger WG, Armitage JO, Schmidt MA. Feasibility of semen cryopreservation in patients with malignant disease. JAMA 1980; 244: 789–790.

    Article  PubMed  CAS  Google Scholar 

  60. Kolodziej FB, Katzorke T, Propping D. [Cryopreservation of human spermatozoa—evaluation of 93 semen depots]. Andrologia 1990; 22: 164–170.

    Article  PubMed  CAS  Google Scholar 

  61. Ragni G, Caccamo AM, Dalla Serra A, et al. Computerized slow-staged freezing of semen from men with testicular tumors or Hodgkin’s disease preserves sperm better than standard vapor freezing. Fertil Steril 1990; 53: 1072–1075.

    PubMed  CAS  Google Scholar 

  62. Sharma RK, Tolentino MV, Thomas AJ, et al. Optimal dose and duration of exposure to artificial stimulants in cryopreserved human spermatozoa. J Urol 1996; 155: 568–573.

    Article  PubMed  CAS  Google Scholar 

  63. Agarwal A, Sidhu RK, Shekarriz M, et al. Optimum abstinence time for cryopreservation of semen in cancer patients. J Urol 1995; 154: 86–88.

    Article  PubMed  CAS  Google Scholar 

  64. Sanger WG, Olson JH, Sherman JK. Semen cryobanking for men with cancer-criteria change. Fertil Steril 1992; 58: 1024–1027.

    PubMed  CAS  Google Scholar 

  65. Scammell GE, White N, Stedronska J, et al. Cryopreservation of semen in men with testicular tumor or Hodgkin’s disease: results of artificial insemination of their partners. Lancet 1985; 2: 31–32.

    Article  PubMed  CAS  Google Scholar 

  66. Khalifa E, Oehninger S, Acosta AA, et al. Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases. Hum Reprod 1992; 7: 105–108.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ohl, D.A., Sonksen, J. (1997). Fertility Issues in the Patient with Testis Cancer. In: Hellstrom, W.J.G. (eds) Male Infertility and Sexual Dysfunction. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1848-7_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1848-7_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7310-3

  • Online ISBN: 978-1-4612-1848-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics