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The Epidemiology of Diabetic Neuropathy

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Clinical Management of Diabetic Neuropathy

Part of the book series: Contemporary Endocrinology ((COE,volume 7))

Abstract

Peripheral neuropathy is a devastating complication of diabetes mellitus because of the debilitating symptoms it causes, or associated higher risk of other complications, in particular those involving the lower extremities. The epidemiology of diabetic neuropathy is not as well-understood as other complications of this metabolic disorder, including retinal, renal, and coronary artery disease. Different peripheral nerves may be damaged through a variety of pathologic processes as described in other chapters of this book. This chapter will review the prevalence, incidence, and risk factors for different types of diabetic neuropathy. The natural history of diabetic neuropathy will be briefly described with regard to foot complications.

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References

  1. Rothman KJ. Modem Epidemiology. Little, Brown, Boston, 1986.

    Google Scholar 

  2. Oh SJ. Clinical Electromyography. University Park, Baltimore, MD, 1984.

    Google Scholar 

  3. Dyck PJ, Kratz KM, Lehman JL, Karnes JL, Melton LJ, O’Brien PC, Litchy WJ, Windebank AJ, Smith BE, Low PA, Service FJ, Rizza RA, Zimmerman BR. The Rochester Diabetic Neuropathy Study: design, criteria for types of neuropathy, selections bias, and reproducibility of neuropathic tests. Neurology 1991;41:799–807.

    Article  PubMed  CAS  Google Scholar 

  4. Franklin GM, Kahn LB, Baxter J, Marshall JA, Hamman RF. Sensory neuropathy in non-insulindependent diabetes mellitus. Am J Epidemiol 1990;131:633–643.

    PubMed  CAS  Google Scholar 

  5. Franklin GF, Shetterly SM, Cohen JA, Baxter J, Hamman RF. Risk factors for distal symmetric neuropathy in NIDDM. Diabetes Care 1994;17:1172–1177.

    Article  PubMed  CAS  Google Scholar 

  6. Maser RE, Steenkiste AR, Dorman JS, Nielsen VK, Bass EB, Manjoo Q, Drash AL, Becker DJ, Kuller LH, Greene DA, et al. Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456–1461.

    Article  PubMed  CAS  Google Scholar 

  7. Maser RE, Nielsen VK, Bass EB, Manjoo Q, Dorman JS, Kelsey SF, Becker DJ, Orchard TJ. Measuring diabetic neuropathy. Assessment and comparison of clinical examination and quantitative sensory testing. Diabetes Care 1989;12:270–275.

    Article  PubMed  CAS  Google Scholar 

  8. Orchard TJ, Dorman JS, Maser RE, Becker DJ, Ellis D, LaPorte RE, Kuller LH, Wolfson SK Jr, Drash AL. Factors associated with avoidance of severe complications after 25 yr of IDDM. Pittsburgh Epidemiology of Diabetes Complications Study I. Diabetes Care 1990;13:741–747.

    Article  PubMed  CAS  Google Scholar 

  9. Kriska AM, LaPorte RE, Patrick SL, Kuller LH, Orchard TJ. The association of physical activity and diabetic complications in individuals with insulin-dependent diabetes mellitus: the Epidemiology of Diabetes Complications Study—VII. J Clin Epidemiol 1991;44:1207–1214.

    Article  PubMed  CAS  Google Scholar 

  10. Harris M, Eastman R, Cowie C. Symptoms of sensory neuropathy in adults with NIDDM in the US population. Diabetes Care 1993;16:1446–1552.

    Article  PubMed  CAS  Google Scholar 

  11. Knuiman MW, Welborn TA, McCann VJ, Stanton KG, Constable IJ. Prevalence of diabetic complications in relation to risk factors. Diabetes 1986;35:1332–1339.

    Article  PubMed  CAS  Google Scholar 

  12. Walters DP, Gatling W, Mullee MA, Hill RD. The prevalence of diabetic distal sensory neuropathy in an English community. Diabetic Med 1992;9:349–353.

    Article  PubMed  CAS  Google Scholar 

  13. Bergenheim T, Borrssen B, Lithner F. Sensory thresholds for vibration, perception, and pain in diabetic patients aged 15-50 years. Diabetes Res Clin Prac 1992;16:47–52.

    Article  CAS  Google Scholar 

  14. Verhoeven S, van Ballegooie E, Casparie AF. Impact of late complications in Type 2 diabetes in a Dutch population. Diabetic Med 1991;8:435–438.

    Article  PubMed  CAS  Google Scholar 

  15. Savettieri G, Rocca WA, Salemi G, Meneghini F, Grigoletto F, Morgante L, Reggio A, Costa V, Coraci MA, Di Perri R. Prevalence of diabetic neuropathy with somatic symptoms: a door-to-door survey in two Sicilian municipalities. Sicilian Neuro-Epidemiologic Study (SNES) Group. Neurology 1993;43:1115–1120.

    Article  PubMed  CAS  Google Scholar 

  16. Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu Tirgoviste, C, Nuber A, Pozza G, Ward JD. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia 1996;39:1377–1384.

    Article  PubMed  CAS  Google Scholar 

  17. UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors. Diabetes Res 1990;13:1–11.

    Article  Google Scholar 

  18. The Diabetes Control and Complications Trial Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med 1995;122:561–568.

    Google Scholar 

  19. Adler AI, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Smith DG. Risk factors for diabetic peripheral sensory neuropathy: results of the Seattle prospective diabetic foot study. Diabetes Care, 1997;20:1162–1167.

    Article  PubMed  CAS  Google Scholar 

  20. Ewing JA. Detecting alcoholism: the CAGE questionnaire. JAMA 1984;252:1905–1907.

    Article  PubMed  CAS  Google Scholar 

  21. Sands ML, Franklin GM, Shetterly SM, Hamman RF. Incidence of distal symmetric (sensory) neuropathy in NIDDM. Diabetes Care 1997;20:322–329.

    Article  PubMed  CAS  Google Scholar 

  22. Lloyd CE, Becker D, Ellis D, Orchard TJ. Incidence of complications in insulin dependent diabetes mellitus: a survival analysis. Am J Epidemiol 1996;143:431–441.

    Article  PubMed  CAS  Google Scholar 

  23. Partanen J, Niskanen LK, Lehtinen J, Mersvaala E, Siitonen O, Uusitupa MIJ. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1995;333:89–94.

    Article  PubMed  CAS  Google Scholar 

  24. Klein R, Klein BEK, Moss SE. Relation of glycemic control to diabetic microvascular complications in diabetes mellitus. Ann Intern Med 1996;124(1 pt 2):90–96.

    PubMed  CAS  Google Scholar 

  25. Sosenko JM, Kato M, Soto R, Bild DE. A prospective study of sensory neuropathy in patients with Type 2 diabetes. Diabetic Med 1993;10:110–114.

    Article  PubMed  CAS  Google Scholar 

  26. Reichard P. Risk factors for progression of microvascular complications in the Stockholm Diabetes Intervention Study (SDIS). Diabetes Res Clin Pract 1992;16:151–156.

    Article  PubMed  CAS  Google Scholar 

  27. Maser RE, Becker DJ, Drash AL, Ellis D, Kuller LH, Greene DA, Orchard TJ. Pittsburgh Epidemiology of Diabetes Complications Study. Measuring diabetic neuropathy follow-up study results. Diabetes Care 1992;15:525–527.

    Article  PubMed  CAS  Google Scholar 

  28. Hillson RM, Hockaday TDR, Newton DJ. Hyperglycemia is one correlate of deterioration in vibration sense during the 5 years after diagnosis of Type 2 (non-insulin-dependent) diabetes. Diabetologia 1984;26:122–126.

    PubMed  CAS  Google Scholar 

  29. Ziegler D, Mayer P, Muhlen H, Gries FA. The natural history of somatosensory and autonomic nerve dysfunction in relation to glycemic control during the first five years after the diagnosis of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1991;34:822–829.

    Article  PubMed  CAS  Google Scholar 

  30. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care 1978;1:168–188.

    Google Scholar 

  31. Maser RE, Pfeifer MA, Dorman JS, Kuller LH, Becker DJ, Orchard TJ. Diabetic autonomie neuropathy and cardiovascular risk. Pittsburgh Epidemiology of Diabetes Complications Study III. Arch Intern Med 1990;150:1218–1222.

    Article  PubMed  CAS  Google Scholar 

  32. Toyry JP, Niskanen LK, Mantysaari MJ, Lansimies EA, Uusitupa MIJ. Occurrence, predictors, and clinical significance of autonomie neuropathy in NIDDM. Ten-year follow-up from diagnosis. Diabetes Care 1996;45:308–315.

    CAS  Google Scholar 

  33. Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O’Brien PC, Melton III LJ, Service FJ. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 1993;43:817–824.

    Article  PubMed  CAS  Google Scholar 

  34. Rith-Najarian SJ, Stolusky T, Gohdes DM. Identifying diabetic patients at high risk for lower-extremity amputation in a primary health care setting. Diabetes Care 1992;15:1386–1389.

    Article  PubMed  CAS  Google Scholar 

  35. Young MJ, Breddy JL, Veves A, Boulton AJM. The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds, a prospective study. Diabetes Care 1994;17:557–560.

    Article  PubMed  CAS  Google Scholar 

  36. Boyko EJ, Ahroni JH, Stensel V, Forsberg R, Smith DG. A prospective study of risk factors for diabetic foot ulcer. Diabetes 1996;45(suppl 2):194A.

    Google Scholar 

  37. Eriksson KF, Nilsson H, Lindgarde F, Osterlin S, Dahlin LB, Lilja B, Rosen I, Sundkvist G. Diabetes mellitus but not impaired glucose tolerance is associated with dysfunction in peripheral nerves. Diabetic Med. 1994;11:279–285.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Edward J. Boyko MD, MPH
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Editors and Affiliations

  1. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Aristidis Veves MD

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© 1998 Springer Science+Business Media New York

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Boyko, E.J. (1998). The Epidemiology of Diabetic Neuropathy. In: Veves, A. (eds) Clinical Management of Diabetic Neuropathy. Contemporary Endocrinology, vol 7. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1816-6_1

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  • DOI: https://doi.org/10.1007/978-1-4612-1816-6_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7296-0

  • Online ISBN: 978-1-4612-1816-6

  • eBook Packages: Springer Book Archive

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