Skip to main content

Ultrastructure of the Striated Muscle Cell

  • Chapter
Book cover Cardiac Markers

Part of the book series: Pathology and Laboratory Medicine ((PLM))

  • 295 Accesses

Abstract

The succeeding chapters deal with the biochemistry and clinical utilization of cardiac markers. This chapter deals with the source of these markers as they are released into the blood following injury. To appreciate this, a knowledge of cell anatomy at the ultrastructural level is necessary. Over the past 50 yr, two technologies have evolved that have enabled us to understand cell structure by providing details not possible with the light microscope. These investigative tools are the electron microscope (EM*) and X-ray diffraction. The former has elucidated the substructure of muscle fibers as seen with routine histology (or polarizing optics), whereas the latter has given us knowledge about the molecular structure of the muscular contractile apparatus (1,2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fawcett DW (1994) Bloom and Fawcett: A Textbook of Histology, Chapman & Hall, New York.

    Google Scholar 

  2. Squire J (1981) The Structural Basis of Muscular Contraction, Plenum Press, New York.

    Book  Google Scholar 

  3. Cormack DH (1993) Essential Histology, J. B. Lippincott Company, Philadelphia, PA.

    Google Scholar 

  4. Junqueira LC et al. (1995) Basic Histology, Appleton & Lange, Stamford, CT.

    Google Scholar 

  5. Ventura-Clapier R, Veksler V, and Hoerter JA (1994) Myofibrillar creatine kinase and cardiac contraction. Mol. Cell Biochem. 133/134:125–144.

    Article  PubMed  Google Scholar 

  6. Franchi LL, Murdoch A, Brown WE, et al. (1990) Subcellular localisation of newly incorporated myosin in rabbit fast skeletal muscle undergoing stimulation-induced type transformation. J. Musc. Res. Cell. Motil. 11:227–239.

    Article  CAS  Google Scholar 

  7. Huxley AF and Nierdergerke R (1954) Structural changes in muscle during contraction. Interference microscopy of living muscle fibers. Nature 173:971–973.

    Article  PubMed  CAS  Google Scholar 

  8. Jorgensen AO, Shen ACY, Campbell KP, and MacClennan DH (1983) Ultrastructural localization of calsequestrin in rat skeletal muscle by immunoferritin labeling of ultrathin frozen selections. J. Cell Biol. 97:1573–1581.

    Article  PubMed  CAS  Google Scholar 

  9. Cuenda A, Nogues M, Gutierrez-Merino C, and de Meis L (1993) Glycogen phospho-rolysis can form a metabolic shuttle to support Ca2+ uptake by sarcoplasmic reticulum membranes in skeletal muscle. Biochem. Biophys. Res. Commun. 196:1127–1132.

    Article  PubMed  CAS  Google Scholar 

  10. Cuenda A, Henao F, Nogues M, and Gutierrez-Merino C (1994) Quantification and removal of glycogen phosphorylase and other enzymes associated with sarcoplasmic reticulum membrane preparations. Biochim. Biophys. Acta. 1194:35–43.

    Article  PubMed  CAS  Google Scholar 

  11. Ganong WF (1995) Review of Medical Physiology, Appleton & Lange, Stamford, CT.

    Google Scholar 

  12. Ebashi S, Endo M, and Ohtsuki I (1969) Control of muscle contraction. Q. Rev. Biophys. 2:351–384.

    Article  PubMed  CAS  Google Scholar 

  13. Block BA, Imagawa T, Campbell KP, and Franzini-Armstrong C (1988) Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J. Cell Biol. 107: 2587–2600.

    Article  PubMed  CAS  Google Scholar 

  14. Goodman, SR (1994) Medical Cell Biology, J. B. Lippincott Company, New York.

    Google Scholar 

  15. Kawai H, Nishino H, Nishida Y, et al. (1987) Localization of myoglobin in human muscle cells by immunoelectron microscopy. Muscle & Nerve 10:144–149.

    Article  CAS  Google Scholar 

  16. Widnell CC and Pfenninger KH (1990) Essential Cell Biology, Williams & Wilkins, Baltimore, MD.

    Google Scholar 

  17. Willerson JT (1995) Cardiovascular Medicine, Churchill Livingstone, New York.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

McCord, R.G., Clark, A.W. (1998). Ultrastructure of the Striated Muscle Cell. In: Wu, A.H.B. (eds) Cardiac Markers. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1806-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1806-7_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7292-2

  • Online ISBN: 978-1-4612-1806-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics