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Biochemistry and Molecular Biology of Troponins I and T

  • Chapter
Cardiac Markers

Part of the book series: Pathology and Laboratory Medicine ((PLM))

Abstract

Troponins I (TnI) and T (TnT) were first recognized as a serum markers of myocar-dial injury in the late 1970s and 1980s, respectively (1,2), but the proteins of the tro-ponin complex are believed to be ancient: appearing some 250 million years ago, before the divergence of avian and mammalian lines (3). An epitope on cardiac tro-ponin T (cTnT,* a 17-residue peptide) has been identified that has been conserved across vertebrate phyla (4), and major portions of the carboxy-terminal region of Tnl are conserved across avian and mammalian species (5). Studies of alternative RNA splicing of exons, one of the mechanism underlying the expression of different TnT isoforms in various striated muscle types, have revealed this to be common to both birds and mammals (6).

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  1. Kenneth J. Dean
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  1. Hartford Hospital, Hartford, CT, USA

    Alan H. B. Wu

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Dean, K.J. (1998). Biochemistry and Molecular Biology of Troponins I and T. In: Wu, A.H.B. (eds) Cardiac Markers. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1806-7_12

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  • DOI: https://doi.org/10.1007/978-1-4612-1806-7_12

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