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Characteristics of Ligand-Gated Ion Channel P2 Nucleotide Receptors

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Book cover The P2 Nucleotide Receptors

Part of the book series: The Receptors ((REC))

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Abstract

P2X receptors are ligand-gated ion channels that activate within milliseconds of agonist binding, causing rapid cellular depolarization and excitation. This makes them ideally suited to mediate the rapid neurotransmitter functions of adenosine 5′-triphosphate (ATP). In the periphery the roles of ATP as an excitatory cotransmitter from sympathetic and parasympathetic nerves have been extensively characterized (Burnstock and Kennedy, 1986; Burnstock, 1990). More recently ATP was also identified as a fast excitatory neurotransmitter in the brain (Edwards et al., 1992). In this section we will discuss the biophysical and pharmacological properties of the P2X receptors that underlie these actions.

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Authors
  1. Charles Kennedy
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  2. Suzanne E. Hickman
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  3. Samuel C. Silverstein
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Editors and Affiliations

  1. Department of Pharmacology, University of Missouri-Columbia, MO, USA

    John T. Turner  & Gary A. Weisman  & 

  2. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Jeffrey S. Fedan

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Kennedy, C., Hickman, S.E., Silverstein, S.C. (1998). Characteristics of Ligand-Gated Ion Channel P2 Nucleotide Receptors. In: Turner, J.T., Weisman, G.A., Fedan, J.S. (eds) The P2 Nucleotide Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1800-5_9

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  • DOI: https://doi.org/10.1007/978-1-4612-1800-5_9

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