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The P2 Nucleotide Receptors pp 185–209Cite as

Cyclic AMP and Tyrosine Kinase Cascades in the Regulation of Cellular Function by P2Y Nucleotide Receptors

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Part of the book series: The Receptors ((REC))

Abstract

Studies on P2Y nucleotide receptor regulation of cellular events and consequences for control of tissue function have concentrated on the inositol-phospholipid phospholipase C (PLC) cascade. It is, however, widely appreciated that activation of PLC and the regulation of cytosolic Ca2+ and protein kinase C (PKC) is not the only mechanism by which cellular function is modulated following activation of this G protein-coupled family of receptors. There are numerous well documented instances of the regulation of cyclic AMP levels by this receptor family, and the consideration of this issue forms the first part of this chapter. Less well accepted is the emerging, and apparently widespread, role of tyrosine phosphorylation cascades in the control of cellular function by the G protein-coupled P2Y receptors. These cascades are those initially studied exclusively with respect to long term control of proliferation and differentiation by the intrinsic tyrosine kinase receptors. In the second part of this chapter we shall consider their involvement in responses to activation of P2Y receptors, focusing on the role of mitogen activated protein kinases (MAPK). Common themes will be signaling crosstalk, particularly the relationship between PLC and the cyclic AMP and tyrosine kinase/MAPK cascades, and examples of coexisting P2Y receptor subtypes differentially regulating these signaling pathways in the same cell.

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  1. Michael R. Boarder
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Editors and Affiliations

  1. Department of Pharmacology, University of Missouri-Columbia, MO, USA

    John T. Turner  & Gary A. Weisman  & 

  2. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Jeffrey S. Fedan

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Boarder, M.R. (1998). Cyclic AMP and Tyrosine Kinase Cascades in the Regulation of Cellular Function by P2Y Nucleotide Receptors. In: Turner, J.T., Weisman, G.A., Fedan, J.S. (eds) The P2 Nucleotide Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1800-5_8

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  • DOI: https://doi.org/10.1007/978-1-4612-1800-5_8

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