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The Role of Nucleotide Receptors in the Cardiovascular System

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The P2 Nucleotide Receptors

Part of the book series: The Receptors ((REC))

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Abstract

The first observation of a biological activity for adenine nucleotides on the cardiovascular system was reported by Drury and Szent-Györgyi in 1929: when administered iv to guinea pigs, adenosine triphosphate (ATP) induced a decrease in heart rate and arterial blood pressure and a dilation of coronary blood vessels. Since that time, multiple effects of nucleotides have been described and much progress has been made in the understanding of their mechanisms of action on different components of the cardiovascular system, including endothelium, smooth muscle cells (SMC), and cardiomyocytes.

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  1. Sabine Pirotton
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  2. Claude Desgranges
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  3. Guy Vassort
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  4. Jean-Marie Boeynaems
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  1. Department of Pharmacology, University of Missouri-Columbia, MO, USA

    John T. Turner  & Gary A. Weisman  & 

  2. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Jeffrey S. Fedan

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Pirotton, S., Desgranges, C., Vassort, G., Boeynaems, JM. (1998). The Role of Nucleotide Receptors in the Cardiovascular System. In: Turner, J.T., Weisman, G.A., Fedan, J.S. (eds) The P2 Nucleotide Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1800-5_13

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