Abstract
Massive transfusion is commonly defined as transfusion approximating or exceeding the patient’s blood volume within a 24-h period (1). In the adult male who weighs 70 kg, this translates to an estimated replacement of 4–5 L of blood, or transfusion of 16–20 U of packed red blood cells (RBCs). These estimates are generally helpful only after the fact in classifying or defining the situation, because both blood loss and volume replacement occur in a short time period and are dynamic processes.
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References
Adverse effects of blood transfusion. In: Technical Manual, 11th ed. Bethesda, MD: American Association of Blood Banks, 1993.
Jeter E, Ross S. Massive transfusion. In: Petz L, ed. Clinical Practice of Transfusion Medicine, 3rd ed. New York: Churchill-Livingstone, 1995, pp. 563–579.
Trunkey D. Trauma. Sci Am 1983;249:28–30.
American College of Surgeons. Advanced Trauma Life Support Manual, 1993, American College of Surgeons, Chicago, IL.
Schriger D, Baraff L, Capillary Refill—Is it a Useful Predictor of Hypovolemic States. Ann Emerg Med 1991;20:601–605.
Knottenbelt J. Low initial hemoglobin levels in trauma patients: an important indicator of ongoing hemorrhage. J Trauma 1991;31:1396–1399.
Yavorski R, Wong R, Maydonovitch C, Battin L, Furnia A, Amundson D. Analysis of 3,294 cases of upper gastrointestional bleeding in military medical facilities. Am J Gastroenterol 1995;90:568–573.
Harrigan C, Lucas C, Ledgerwood A, Mannen E. Primary hemostasis after massive transfusion for injury. Surgery 1985;98:836–840.
Phillips T, Soulier G, Wilson R. Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery. J Trauma 1987;27:903–908.
Wilson R, Mammen E, Walt E. Eight years of experience with massive blood transfusion. J Trauma 1971;11:275–278.
Rutledge R, Sheldon G, Collins M. Massive transfusion. Crit Care Clinics 1986;2:791–793.
Wudel J, Morris J, Yates K, Wilson A, Bass S. Massive transfusion: outcome in blunt trauma patients. J Trauma 1991;31:1–7.
Frey C, Huelke D, Gikas P. Resuscitation and survival in motor vehicle accidents. J Trauma 1969;9:292–298.
Olsen W. Quantitative peritoneal lavage in blunt abdominal trauma. Arch Surg 1972;104:536–539.
Mucha P, Welch T. Hemorrhage in major pelvic fractures. Surg Clin North Am 1988;68:757–780.
Sawyer P, Harrison C. Massive transfusion in adults. Vox Sanguinis 1990;58:199–202.
Kivioja A, Myllynen P, Rokkanen P. Survival after massive transfusions exceeding four blood volumes in patients with blunt injuries. Am Surg 1991;57:398–402.
Harvey M, Greenfield T, Sugrue M, Rosenfeld D. Massive blood transfusion in a tertiary referral hospital. Clinical outcomes and hemostatic complications. Med J Aust 1995;163:356–359.
Harrigan C, Lucas C, Ledgerwood A. The effect of hemorrhagic shock on the clotting cascade in injured patients. J Trauma 1989;29:1416–1420.
Mitchell KJ, Moncure KE, Onyeije C, Rao MS, Siram S. Evaluation of massive volume replacement in the penetrating trauma patient. J Natl Med Assoc 1994;86(12):926–929.
Canizaro P, Possa M. Management of massive hemorrhage associated with abdominal trauma. Surg Clin North Am 1990;70:621–625.
Faringer P, Mullins R, Johnson R, Trunkey D. Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients. J Trauma 1993;34:481–486.
Samama CM. Traumatic emergencies and hemostasis. Can J Anesthesiol 1995;43(5):479–482.
Schmidt P. Use of Rh positive blood in emergency situations. Surg Gyn Ob 1988;167:229–233.
Schwab C, Shayne J, Turner J. Immediate trauma resuscitation with type O uncross-matched blood: a two-year prospective experience. J Trauma 1986;26:897–901.
Bickell WH, Wall MJ, Jr., Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994;331:1105–1109.
Janvier G, Fialon P, Guinier MC, Sztark F, Lassie P, Roger I. Strategy of erythrocyte transfusion and plasma use in traumatic emergencies. Can J Anesthesiol 1994;42:643–649.
Audibert G. Indications of blood components and outcome of transfusion practices in hemorrhage of multiple trauma. Can J Anesthesiol 1994;42:391–394.
Gervin A, Fischer R. Resuscitation of trauma patients with type-specific uncross-matched blood. J Trauma 1984;24:327–331.
Gervin A. Transfusion, autotransfusion, and blood substitutes. In: Moore E, Mattox K, Feliciano D, eds. Trauma, 2nd ed. Norwalk, CT: Appleton and Lange, 1991, pp. 165–173.
Bowersox JC, Hess JR. Trauma and military applications of blood substitutes. Artif Cells Blood Substit Immobil Biotechnol 1994;22(2):145–157.
Humphries JE. Transfusion therapy in acquired coagulopathies. Hematol Oncol Clin North Am 1994;8:1181–1201.
Counts R, Haisch C, Simon T, Maxwell N, Heimbach D. Hemostasis in massively transfused trauma patients. Ann Surg 1979;190:91–96.
Murray DJ, Pennell BJ, Weinstein SL, Olsen JD. Packed red cells in acute blood loss: dilutional coagulopathy as a cause of surgical bleeding. Anesth Analg 1995;80:336–342.
Harke H, Rahman S. Haemostatic disorders in massive transfusion. Bibliotheca Haemat 1980;46:179–183.
Noe D, Graham S., Luff R, Sohmer P. Platelet counts during rapid massive transfusion. Transfusion 1982;22:392–396.
Mannucci P, Federici A, Sirchia G. Hemostasis testing during massive blood replacement. Vox Sanguinis 1982;42:113–118.
Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995;81:360–365.
Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A. Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. Lancet 1996;347:289–292.
Nathan HJ, Polis T. The management of temperature during hypothermic cardio-pulmonary bypass: II—Effect of prolonged hypothermia. Can J Anaesth 1995;42:672–676.
Valeri C, Cassidy G, Khuri S, Feingold H, Ragno G. Hypothermia-induced reversible platelet dysfunction. Ann Surg 1987;205:175–180.
Bick R. Disseminated intravascular coagulation and related syndromes: a clinical review. Sem Thromb Hemo 1988;14:299–305.
Rohrer MJNA. Effect of hypothermia on the coagulation cascade. Crit Care Med 1992;20:1402–1408.
Nicholls MD, Whyte G. Red cell, plasma and albumin transfusion decision triggers. Anaesth Intensive Care 1993;21:156–162.
Collins J. Problems associated with the massive transfusion of stored blood. Surgery 1974;75:274–278.
Lucas C, Ledgerwood A. Clinical significance of altered coagulation test after massive transfusions for trauma. Am Surg 1981;47:125–129.
Hewson J, Neame P, Kumar N, Ayrton A, Gregor P. Coagulopathy related to dilution and hypotension during massive transfusion. Crit Care Med 1985;13:387–392.
Bunker J. Metabolic effects of blood transfusions. Anesthesiology 1966;27:446–450.
Valeri C, Gray A, Cassidy G, Riordan W, Pivacek L. The 24-hour post-transfusion survival, oxygen transport function, and residual hemolysis of human outdated-rejuvenated red cell concentrate after washing and storage at 4 degrees C for 24 to 72 hours. Transfusion 1984;24:323–328.
Wolfe L. The membrane and lesions of storage in preserved red cells. Transfusion 1985;25:185–189.
Sazama K. Reports of 355 transfusion-associated deaths: 1976 through 1985. Transfusion 1990;30:583–588.
Gloe D. Common reactions to transfusions. Heart Lung 1991;20:506–512.
Seyfried H, Walewska I. Immune hemolytic transfusion reactions. World J Surg 1987;11:25–29.
Kroll H, Kiefel V, Mueller-Eckhardt C. Post-transfusion purpura: clinical and immunologic studies in 38 patients. Infusionsther Transfusionsmed 1993;20:198–204.
Blumberg N, Hea IJ. Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection. Yale J Biol Med 1990;63:429–433.
Crosby ET. Perioperative haemotherapy: II. Risks and complications of blood transfusion. Can J Anaesth 1992;39:822–837.
Rieger A, Saefkow M, Hass I, Spies C, Eyrich K. Feasibility and rate of leucocyte depletion with a single leucocyte depletion filter during massive transfusion. Infusionsther Transfusionsmed 1995;22:355–359.
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Spence, R.K. (1998). Massive Transfusion. In: Reid, M.E., Nance, S.J. (eds) Red Cell Transfusion. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1798-5_9
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DOI: https://doi.org/10.1007/978-1-4612-1798-5_9
Publisher Name: Humana Press, Totowa, NJ
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