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Morphoregulatory Mechanisms Underlying Early Heart Development: Precardiac Stages to the Looping, Tubular Heart

  • Chapter
Living Morphogenesis of the Heart

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

Abstract

The formation of a single, beating, tubular heart in the embryo by the fusion of the two endocardial tubes is one of the early processes leading to normal heart development. Because of the prominence of this developmental event, there is often an underlying assumption that abnormalities that may lead to congenital heart disease arise during this fusion process and in the developmental events that follow during the later modeling of the chambers, septa, and valves. There is truth in this, but the developmental processes that take place before this are of equal or greater importance for cardiovascular development.

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Authors
  1. Kersti K. Linask
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  2. James W. Lash
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Editors and Affiliations

  1. Departamento de Biología del Desarrollo y Teratogénesis, Hospital Infantil de México “Federico Gómez”, México, D. F. C. P. 06720, México

    MarĂ­a Victoria de la Cruz M. D.

  2. Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC, 29425, USA

    Roger R. Markwald Ph.D.

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Linask, K.K., Lash, J.W. (1998). Morphoregulatory Mechanisms Underlying Early Heart Development: Precardiac Stages to the Looping, Tubular Heart. In: de la Cruz, M.V., Markwald, R.R. (eds) Living Morphogenesis of the Heart. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1788-6_1

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  • DOI: https://doi.org/10.1007/978-1-4612-1788-6_1

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