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Crossbridge Cycling and Cooperative Recruitment Can Account for Oscillatory Dynamics of Constantly Activated Heart

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Abstract

We have shown on several occasions that the pressure response to a small-amplitude volume change (both sinusoids and steps) in the constantly activated heart is identical to the force response to a small-amplitude length change in constantly activated cardiac muscle (3–9). One pattern of dynamic responses in both preparations implies that the mechanisms responsible for small-amplitude mechanodynamics in the intact heart are the same as those responsible for mechanodynamics in muscle. The common underlying mechanism in both preparations is the interaction between the thick and thin myofilaments via cycling crossbridges. Thus, it is possible to observe crossbridge dynamics in the intact heart just as in isolated muscle preparations of a few sarcomeres.

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References

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© 1998 Springer Science+Business Media New York

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Campbell, K.B., Kirkpatrick, R.D. (1998). Crossbridge Cycling and Cooperative Recruitment Can Account for Oscillatory Dynamics of Constantly Activated Heart. In: Analysis and Assessment of Cardiovascular Function. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1744-2_4

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  • DOI: https://doi.org/10.1007/978-1-4612-1744-2_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7261-8

  • Online ISBN: 978-1-4612-1744-2

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