Chronological Time Versus Physiological Time

  • James L. Hargrove
Part of the Modeling Dynamic Systems book series (MDS)


If one were to ask a number of people what physiological rhythm they most closely associate with the passage of time, most would probably choose the heart rate. We are consciously aware of this pacemaker in quiet moments just prior to sleep, and we become acutely aware of it during exertion or when frightened or angry. Most students have probably estimated the number of times the heart will beat during a lifetime, and some people morbidly reflect on how many heartbeats have passed and how few remain.


Metabolic Rate Caloric Restriction Basal Metabolic Rate Turnover Time Standard Metabolic Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Booth, J., E. Boyland, and C. Cooling. “The respiration of human liver tissue.” Biochem. Pharmacol. 16 (1967): 721–724.CrossRefPubMedGoogle Scholar
  2. Boxenbaum, H. “Time concepts in physics, biology, and pharmacokinetics.” J. Pharmaceut Sci. 75 (1986): 1053–1062.CrossRefGoogle Scholar
  3. Calder, W.A., III. Size, Function, and Life History. Cambridge, Mass.: Harvard University Press, 1984.Google Scholar
  4. Hainsworth, F.R. Animal Physiology: Adaptations in Function. Reading, Mass: Addison-Wesley, 1981, 170.Google Scholar
  5. Kleiber, M. The Fire of Life. New York: John Wiley, 1961.Google Scholar
  6. Lindstedt, S.L. and WA. Calder. “Body size, physiological time, and longevity of homeothermic animals.” Quart. Rev. Biol. 56 (1981): 1–16.CrossRefGoogle Scholar
  7. Lynn, W.S., and J.C. Wallwork. “Does food restriction retard aging by reducing metabolic rate?” J. Nutr. 122 (1992): 1917–1918.PubMedGoogle Scholar
  8. Masoro, E.J., and R.J.M. McCarter. “Dietary restriction as a probe of mechanisms of senescence,” In: Annual Review of Gerontology and Geriatrics (Christofalo, V.J., and M.P. Lawton, eds.) Vol. 10. New York: Springer Publishing, 1990, 183–197.Google Scholar
  9. McCarter, R.J., and J. Palmer. “Energy metabolism and aging: a lifelong study in Fischer-344 rats.” Am. J. Physiol. 263 (1992): E448–E452.PubMedGoogle Scholar
  10. McMahon, T.A. “Scaling physiological time.” Lectures on Mathematics in the Life Sciences 12: (Amer. Math. Soc. 1980), 131–163.Google Scholar
  11. Pearl, R. The Rate of Living. New York: Alfred Knopf, 1928.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • James L. Hargrove
    • 1
  1. 1.Department of Foods and NutritionUniversity of GeorgiaAthensUSA

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