Positive and Negative Feedback: Insulin and the Use of Fatty Acids and Glucose for Energy

  • James L. Hargrove
Part of the Modeling Dynamic Systems book series (MDS)


Every student of physiology learns the concept of negative feedback, whether it be in terms of baroreceptors and blood pressure, the control of glucose metabolism by insulin, calcium regulation by parathyroid hormone, or sodium regulation of renin, angiotensin, and aldosterone. Due to the growing prevalence of diabetes and the pioneering identification of insulin as the major regulator of blood glucose by Banting and Best, many kineticists have developed dynamic models of insulin secretion and glucose dynamics (Bergman, 1989; Biermann, 1994; Gatewood et al., 1970; Segre et al., 1973). Part of the reason for the interest is the idea that the serious conditions that affect patients with diabetes (such as heart and kidney disease, retinal degeneration and blindness, loss of peripheral nerve function, and bouts of gangrene) may be ameliorated with better glycemic control (Bellomo et al., 1982). A highly pragmatic reason for this interest is not only to understand the distinctions among the different types of diabetes, but also to attain better blood glucose control by use of the artificial pancreas for detection of blood glucose and infusion of insulin (Abisser et al., 1974; Hauser et al., 1994).


Insulin Secretion Oral Glucose Tolerance Test Respiratory Quotient Good Glycemic Control Artificial Pancreas 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • James L. Hargrove
    • 1
  1. 1.Department of Foods and NutritionUniversity of GeorgiaAthensUSA

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