Compartmental Models in Metabolic Studies: Vitamin C

  • James L. Hargrove
Part of the Modeling Dynamic Systems book series (MDS)


STELLA® and similar computer programs allow one to use modeling and simulation as a tool for thinking. However, no one has time to squander; our modeling should have a purpose. Also, in coming to grips with questions, one must consider the rich source of data that is already available in the scientific literature. Modeling has been used as a quantitative tool to answer many significant medical questions, and simulation programs such as STELLA® may be used to interpret this information. Much of this information has been reported in a format derived from compartmental analysis. The purpose of this chapter is to introduce this method and ideas about using STELLA® to help interpret this kinetic information. Let us note that the comment quoted above concerning model development and testing implies a need to apply statistical methods to ensure that a model functions in a robust manner. However, it is reasonable for the student to use models that have already been developed with these research methods.


Blood Plasma Compartmental Model Compartmental Analysis Plasma Ascorbic Acid Multicompartment Model 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • James L. Hargrove
    • 1
  1. 1.Department of Foods and NutritionUniversity of GeorgiaAthensUSA

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