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Autoimmune Reactions pp 113–140Cite as

T-Cell Antigen Receptor Repertoire in Rheumatoid Arthritis

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Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

Rheumatoid arthritis (RA) is an organ-specific, but often also systemic autoimmune disease initiated and maintained by a chronic cell-mediated and humoral inflammatory response. T-cell response(s) to unknown antigen(s) are thought to be at the origin of RA, because early synovial histopathology resembles classic delayed type hypersensitivity and includes prominent infiltration consisting of antigen presenting dendritic cells clustered with CD4+ T-cells (1–7) in a perivascular location. Moreover, T-cell depleting therapy in RA, and in animal models of RA, can be beneficial. Finally, genetic susceptibility to RA is strikingly associated with certain MHC class II alleles which may either control peptide presentation to T-cells or influence T-cell repertoires during thymic maturation.

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References

  1. Van Boxel, J. A. and Paget, S. A. (1975) Predominantly T-cell infiltrate in rheumatoid synovial membranes. N. Engl. J. Med. 293, 517–520.

    PubMed  Google Scholar 

  2. Kurosaka, M. and Ziff, M. (1983) Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J. Exp. Med. 158, 1191–1210.

    PubMed  CAS  Google Scholar 

  3. Randen, I., Mellbye, O. J., Forre, O., and Natvig, J. B. (1995) The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand. J. Immunol. 41, 481–486.

    PubMed  CAS  Google Scholar 

  4. Thomas, R. and Quinn, C. (1996) Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium. J. Immunol. 156, 3074–3086.

    PubMed  CAS  Google Scholar 

  5. Thomas, R., Davis, L S., and Lipsky, P.E. (1994) Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J. Immunol. 152, 2613–2623.

    CAS  Google Scholar 

  6. Stagg, A. J., Harding, B., Hughes, R. A., Keat, A., and Knight, S. C. (1991) The distribution and functional properties of dendritic cells in patients with seronegative arthritis. Clin. Exp. Immunol. 84, 66–71.

    PubMed  CAS  Google Scholar 

  7. Waalen, K., Forre, O., Pahle, J., Natvig, J. B., and Burmester, G. R. (1987) Characteristics of human rheumatoid synovial and normal blood dendritic cells. Retention of class II major histocompatibility complex antigens and accessory function after short-term culture. Scand. J. Immunol. 26, 525–533.

    PubMed  CAS  Google Scholar 

  8. Vyse, T. J. and Todd, J. A. (1996) Genetic analysis of autoimmune disease. Cell 85, 311–318.

    PubMed  CAS  Google Scholar 

  9. Gregersen, P. K., Silver, J., and Winchester, R. J. (1987) The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205–1213.

    PubMed  CAS  Google Scholar 

  10. Weyand, C. M., Hicok, K. C., Conn, D. L., and Goronzy, J. J. (1992) The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis (see comments). Ann. Intern. Med. 117, 801–806.

    PubMed  CAS  Google Scholar 

  11. Wallin, J., Hillert, J., Olerup, O., Carlsson, B., and Strom, H. (1991) Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with T cell receptor beta chain gene alleles or haplotypes (see comments). Arthritis Rheum. 34, 1416–1424.

    PubMed  CAS  Google Scholar 

  12. Boki, K. A., Panayi, G. S., Vaughan, R. W., Drosos, A. A., Moutsopoulos, H. M., and Lanchbury, J. S. (1992) HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients. Arthritis Rheum. 35, 749–755.

    PubMed  CAS  Google Scholar 

  13. Boki, K. A., Drosos, A. A., Tzioufas, A. G., Lanchbury, J. S., Panayi, G. S., and Moutsopoulos, H. M. (1993) Examination of HLA-DR4 as a severity marker for rheumatoid arthritis in Greek patients. Ann. Rheum. Dis. 52, 517–519.

    PubMed  CAS  Google Scholar 

  14. Hammer, J., Gallazzi, F., Bono, E., Karr, R. W., Guenot, J., Valsasnini, P., et al. (1995) Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association (see comments). J. Exp. Med. 181, 1847–1855.

    PubMed  CAS  Google Scholar 

  15. Wucherpfennig, K. W. and Strominger, J. L. (1995) Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases (comment). J. Exp. Med. 181, 1597–1601.

    PubMed  CAS  Google Scholar 

  16. Thomson, W., Pepper, L., Payton, A., Carthy, D., Scott, D., Ollier, W., et al. (1993) Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community. Ann. Rheum. Dis. 52, 539–541.

    PubMed  CAS  Google Scholar 

  17. Weyand, C.M., Xie, C., and Goronzy, J. J. (1992) Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. J. Clin. Invest. 89, 2033–2039.

    PubMed  CAS  Google Scholar 

  18. Calin, A., Eiswood, J., and Klouda, P. T. (1989) Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study (see comments). Arthritis Rheum. 32, 1221–1225.

    PubMed  CAS  Google Scholar 

  19. Jawaheer, D., Thomson, W., MacGregor, A. J., Carthy, D., Davidson, J., Dyer, P. A., et al. (1994) “Homozygosity” for the HLA-DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins. Arthritis Rheum. 37, 681–686.

    PubMed  CAS  Google Scholar 

  20. Berg, L. J., Frank, G. D., and Davis, M. M. (1990) The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell 60, 1043–1053.

    PubMed  CAS  Google Scholar 

  21. Robey, E. A., Ramsdell, F., Kioussis, D., Sha, W., Loh, D., Axel, R., et al., (1992) The level of CD8 expression can determine the outcome of thymic selection. Cell 69, 1089–1096.

    PubMed  CAS  Google Scholar 

  22. Zanelli, E., Krco, C. J., Baisch, J. M., Cheng, S., and David, C. S. (1996) Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 93, 1814–1819.

    PubMed  CAS  Google Scholar 

  23. Zanelli, E., Gonzalez-Gay, M. A., and David, C. A. (1995) Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol. Today 16, 274–278.

    PubMed  CAS  Google Scholar 

  24. Kong, Y. C., Lomo, L. C., Motte, R. W., Giraldo, A. A., Baisch, J., Strauss, G., et al. (1996) HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J. Exp. Med. 184, 1167–1172.

    PubMed  CAS  Google Scholar 

  25. Ito, K., Bian, H. J., Molina, M., Han, J., Magram, J., Saar, E., et al. (1996) HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J. Exp. Med. 183, 2635–2644.

    PubMed  CAS  Google Scholar 

  26. Schwartz, B. D. (1994) HLA class II transgenic mice: the chance to unravel the basis of HLA class II associations with disease (comment). J. Exp. Med. 180, 11–13.

    PubMed  CAS  Google Scholar 

  27. Altmann, D. M., Douek, D. C., Frater, A. J., Hetherington, C. M., Inoko, H., and Elliott, J. I. (1995) The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J. Exp. Med. 181, 867–875.

    PubMed  CAS  Google Scholar 

  28. Rosloniec, E. F., Brand, D. D., Myers, L. K., Whittington, K. B., Gumanovskaya, M., Zaller, D. M., et al. (1997) An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J. Exp. Med. 185, 1113–1122.

    PubMed  CAS  Google Scholar 

  29. Yeung, R. S., Penninger, J. M., Kundig, T. M., Law, Y., Yamamoto, K., Kamikawaji, N., et al. (1994) Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. J. Exp. Med. 180, 1911–1920.

    PubMed  CAS  Google Scholar 

  30. Firestein, G. S. (1997) Etiology and pathogenesis of rheumatoid arthritis, in Textbook of Rheumatology (Kelley, W. N., Harris, E. D., Ruddy, S., and Sledge, C. R., eds.), WB Saunders, Philadelphia, PA, pp. 851–897.

    Google Scholar 

  31. Asch, E. S., Bujak, D. I., Weiss, M., Peterson, M. G., and Weinstein, A. (1994) Lyme disease: an infectious and postinfectious syndrome. J. Rheumatol. 21, 454–461.

    PubMed  CAS  Google Scholar 

  32. Harris, E. D., Jr. (1993) Etiology and pathogenesis of rheumatoid arthritis, in Rheumatoid Arthritis (Kelley, W. N., Jarris, E. D., Ruddy, S., and Sledge, C. R., eds.), WB Saunders, Philadelphia, PA, pp. 833–873.

    Google Scholar 

  33. Thomas, R. and Lipsky, P. E. (1996) Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis? Immunol Today 17, 559–564.

    PubMed  CAS  Google Scholar 

  34. Tsai, V., Bergroth, V., and Zvaifler, N. J. (1988) Synovial dendritic cells and T cells in rheumatoid arthritis. Scand. J. Rheumatol. Suppl. 74, 79–88.

    PubMed  CAS  Google Scholar 

  35. Zvaifler, N. J., Steinman, R. M., Kaplan, G., Lau, L. L., and Rivelis, M. (1985) Identification of immunostimulatory dendritic cells in the synovial effusions of patients with rheumatoid arthritis. J. Clin. Invest. 76, 789–800.

    PubMed  CAS  Google Scholar 

  36. Wilkinson, L. S., Worrall, J. G., Sinclair, H. D., and Edwards, J. C. (1990) Immunohistological reassessment of accessory cell populations in normal and diseased human synovium. Br. J. Rheumatol. 29, 259–263.

    PubMed  CAS  Google Scholar 

  37. Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271–296.

    PubMed  CAS  Google Scholar 

  38. Ziff, M. (1974) Relation of cellular infiltration of rheumatoid synovial membrane to its immune response. Arthritis Rheum. 17, 313–319.

    PubMed  CAS  Google Scholar 

  39. Jorgensen, C., Travaglio-Encinoza, A., Bologna, C., d’Angeac, A. D., Reme, T., and Sany, J. (1994) Human mucosyl lymphocyte marker expression in synovial fluid lymphocytes of patient with rheumatoid arthritis. J. Rheumatol. 21, 1602–1607.

    PubMed  CAS  Google Scholar 

  40. Trollmo, C., Nilsson, I. M., Sollerman, C., and Tarkowski, A. (1996) Expression of the mucosal lymphocyte integrin alpha E beta 7 and its ligand E-cadherin in the synovium of patients with rheumatoid arthritis. Scand. J. Immunol. 44, 293–298.

    PubMed  CAS  Google Scholar 

  41. Salmi, M., Andrew, D. P., Butcher, E. C., and Jalkanen, S. (1995) Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms. J. Exp. Med. 181, 137–149.

    PubMed  CAS  Google Scholar 

  42. Gross, G. G., Schwartz, V. L., Stevens, C., Ebert, E. C., Blumberg, R. S., and Balk, S. P. (1994) Distribution of dominant T cell receptor beta chains in human intestinal mucosa. J. Exp. Med. 180, 1337–1344.

    PubMed  CAS  Google Scholar 

  43. Regnault, A., Cumano, A., Vassalli, P., Guy-Grand, D., and Kourilsky, P. (1994) Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/ beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells. J. Exp. Med. 180, 1345–1358.

    PubMed  CAS  Google Scholar 

  44. Chowers, Y., Holtmeier, W., Harwood, J., Morzycka-Wroblewska, E., and Kagnoff, M.F. (1994). The Vδ1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180, 183–190.

    PubMed  CAS  Google Scholar 

  45. Gross, V., Andus, T., Leser, H.G., Roth, M., and Scholmerich, J. (1991) Inflammatory mediators in chronic inflammatory bowel diseases. Klin. Wochenschr. 69, 981–987.

    PubMed  CAS  Google Scholar 

  46. Zhang, L. and Tarleton, R. L. (1996) Persistent production of inflammatory and anti-inflammatory cytokines and associated MHC and adhesion molecule expression at the site of infection and disease in experimental Trypanosoma cruzi infections. Exp. Parasitol. 84, 203–213.

    PubMed  CAS  Google Scholar 

  47. Imamura, M., Hashino, S., Kobayashi, H., Kubayashi, S., Hirano, S., Minagawa, T., et al. (1994) Serum cytokine levels in bone marrow transplantation: synergistic interaction of interleukin-6, interferon-gamma, and tumor necrosis factor-alpha in graft-versus-host disease. Bone Marrow Transp. 13, 745–751.

    CAS  Google Scholar 

  48. Rus, V., Svetic, A., Nguyen, P., Gause, W. C., and Via, C. S. (1995) Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J. Immunol. 155, 2396–2406.

    PubMed  CAS  Google Scholar 

  49. Karin, N., Szafer, F., Mitchell, D., Gold, D. P., and Steinman, L. (1993) Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J. Immunol. 150, 4116–4124.

    PubMed  CAS  Google Scholar 

  50. Yu, M., Johnson, J. M., and Tuohy, V. K. (1996) A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183, 1777–1788.

    PubMed  CAS  Google Scholar 

  51. Lannes-Vieira, J., Gehrmann, J., Kreutzberg, G. W., and Wekerle, H. (1994) The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: distinct nature of parenchymal and perivascular infiltrates. Acta Neuropathol. (Berl.) 87, 435–442.

    CAS  Google Scholar 

  52. Tsuchida, M., Matsumoto, Y., Hirahara, H., Hanawa, H., Tomiyama, K., and Abo, T. (1993) Preferential distribution of V beta 8.2-positive T cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 23, 2399–2406.

    PubMed  CAS  Google Scholar 

  53. Jansson, L., Diener, P., Engstrom, A., Olsson, T., and Holmdahl, R. (1995) Spreading of the immune response to different myelin basic protein peptides in chronic experimental autoimmune encephalomyelitis in B10.RIII mice. Eur. J. Immunol. 25, 2195–2200.

    PubMed  CAS  Google Scholar 

  54. Lehmann, P. V., Forsthuber, T., Miller, A., and Sercarz, E. E. (1992) Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358, 155–157.

    PubMed  CAS  Google Scholar 

  55. Lehmann, P. V., Sercarz, E. E., Forsthuber, T., Dayan, C. M., and Gammon, G. (1993) Determinant spreading and the dynamics of the autoimmune T-cell repertoire (see comments). Immunol. Today 14, 203–208.

    PubMed  CAS  Google Scholar 

  56. Tarkowski, A., Jonsson, R., Holmdahl, R., and Klareskog, L. (1987) Immunohis-tochemical characterization of synovial cells in arthritic MRL-1pr/1pr mice. Arthritis Rheum. 30, 75–82.

    PubMed  CAS  Google Scholar 

  57. Koopman, W. J., and Gay, S. (1988) The MRL-1pr/1pr mouse: a model for the study of rheumatoid arthritis. Scand. J. Rheumatol Suppl. 75, 284–289.

    PubMed  CAS  Google Scholar 

  58. Westby, M., Manca, F., and Dalgleish, A.G. (1996) The role of host immune responses in determining the outcome of HTV infection. Immunol. Today 17, 120–126.

    PubMed  CAS  Google Scholar 

  59. Posnett, D. N., Romagne, F., Necker, A., Kotzin, B. L., and Sekaly, R. P. (1996) Summary: First human TCR monoclonal antibody workshop. The Immunologist 4, 5–8.

    CAS  Google Scholar 

  60. Marguerie, C., Lunardi, C., and So, A. (1992) PCR-based analysis of the TCR repertoire in human autoimmune diseases (see comments). Immunol. Today 13, 336–338.

    PubMed  CAS  Google Scholar 

  61. Posnett, D. N. (1995) Environmental and genetic factors shape the human T-cell receptor repertoire. Ann NY Acad. Sci. 756, 71–80.

    PubMed  CAS  Google Scholar 

  62. Robinson, M. A. (1995) T-cell receptors in immune responses. Adv. Exp. Med. Biol. 386, 121–132.

    PubMed  CAS  Google Scholar 

  63. Struyk, L., Hawes, G. E., Chatila, M. K., Breedveld, F. C., Kurnick, J. T., and van den Elsen, P. J. (1995) T cell receptors in rheumatoid arthritis. Arthritis Rheum. 38, 577–589.

    PubMed  CAS  Google Scholar 

  64. Sumida, T., Hoa, T. T., Asahara, H., Hasunuma, T., and Nishioka, K. (1997) T cell receptor of Fas-sensitive T cells in rheumatoid synovium. J. Immunol. 158, 1965–1970.

    PubMed  CAS  Google Scholar 

  65. Salmon, M., Scheel-Toellner, D., Huissoon, A. P., Pilling, D., Shamsadeen, N., Hyde, H., et al. (1997) Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 99, 439–446.

    PubMed  CAS  Google Scholar 

  66. Karim, S. N., Murphy, E. A., Sturrock, R. D., and Goudie, R. B. (1995) T-cell clonality in synovial fluid from rheumatoid joints before and after culture in interleukin-2. Br. J. Rheumatol. 34, 232–235.

    PubMed  CAS  Google Scholar 

  67. Posnett, D. N., Gottlieb, A., Bussel, J. B., Friedman, S. M., Chiorazzi, N., Li, Y., et al. (1988). T cell antigen receptors in autoimmunity. J. Immunol. 141, 1963–1969.

    PubMed  CAS  Google Scholar 

  68. Kohsaka, H., Taniguchi, A., Chen, P. P., Ollier, W. E., and Carson, D. A. (1993) The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzymelinked immunosorbent assay. Eur. J. Immunol. 23, 1895–1901.

    PubMed  CAS  Google Scholar 

  69. Nanki, T., Kohsaka, H., Mizushima, N., Ollier, W. E., Carson, D. A., and Miyasaka, N. (1996) Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. J. Clin. Invest. 98, 1594–1601.

    PubMed  CAS  Google Scholar 

  70. Kohsaka, H., Chen, P. P., Taniguchi, A., Ollier, W. E., and Carson, D. A. (1993) Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins. Arthritis Rheum. 36, 213–221.

    PubMed  CAS  Google Scholar 

  71. Uematsu, Y., Wege, H., Straus, A. L., Ott, M., Bannwarth, W., Lanchbury, J., et al. (1991) The T-cell receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc. Natl. Acad. Sci. USA 88, 8534–8538.

    PubMed  CAS  Google Scholar 

  72. Pluschke, G., Ricken, G., Taube, H., Kroninger, S., Melchers, I., Peter, H. H., Eichman, K., and Grom, U. (1991) Biased T cell receptor Vα region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur. J. Immunol. 21, 2749–2754.

    PubMed  CAS  Google Scholar 

  73. Mima, T., Saeki, Y., Ohshima, S., Nishimoto, N., Matsushita, M., Shimizu, M., et al. (1995) Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints. J. Clin. Invest. 96, 1746–1758.

    PubMed  CAS  Google Scholar 

  74. Sakata, A., Sakata, K., Ping, H., Ohmura, T., Tsukano, M., and Kakimoto, K. (1996) Successful induction of severe destructive arthritis by the transfer of in vitro-activated synovial fluid T cells from patients with rheumatoid arthritis (RA) in severe combined immunodeficient (SCID) mice. Clin. Exp. Immunol. 104, 247–254.

    PubMed  CAS  Google Scholar 

  75. Jenkins, R. N., Nikaein, A., Zimmermann, A., Meek, K., and Lipsky, P. E. (1993) T cell receptor V beta gene bias in rheumatoid arthritis. J. Clin. Invest. 92, 2688–2701.

    PubMed  CAS  Google Scholar 

  76. Waase, I., Kayser, C., Carlson, P. J., Goronzy, J. J., and Weyand, C. M. (1996) Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum. 39, 904–913.

    PubMed  CAS  Google Scholar 

  77. Williams, W. V., Fang, Q., Demarco, D., Von Feldt, J., Zurier, R. B., and Weiner, D. B. (1992) Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J. Clin. Invest. 90, 326–333.

    PubMed  CAS  Google Scholar 

  78. Goronzy, J. J., Bartz-Bazzanella, P., Hu, W., Jendro, M. C., Walser-Kuntz, D. R., and Weyand, C. M. (1994) Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis. J. Clin. Invest. 94, 2068–2076.

    PubMed  CAS  Google Scholar 

  79. Bucht, A., Soderstrom, K., Hultman, T., Uhlen, M., Nilsson, E., Kiessling, R., et al. (1992) T cell receptor diversity and activation markers in the Vδ1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes. Eur. J. Immunol. 22, 567–574.

    PubMed  CAS  Google Scholar 

  80. Olive, C., Gatenby, P. A., and Serjeantson, S. W. (1992) Variable gene usage of T cell receptor gamma-and delta-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis. Clin. Exp. Immunol. 87, 172–177.

    PubMed  CAS  Google Scholar 

  81. Meliconi, R., Pitzalis, C., Kingsley, G. H., and Panayi, G. S. (1991) Gamma/delta T cells and their subpopulations in blood and synovial fluid from rheumatoid arthritis and spondyloarthritis. Clin. Immunol. Immunopathol. 59, 165–172.

    PubMed  CAS  Google Scholar 

  82. Schmidt, D., Goronzy, J. J., and Weyand, C. M. (1996) CD4+ CD7”CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J. Clin. Invest. 97, 2027–2037.

    PubMed  CAS  Google Scholar 

  83. David-Ameline, J., Lim, A., Davodeau, F., Peyrat, M. A., Berthelot, J. M., Semama, G., et al. (1996) Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis. J. Immunol. 157, 4697–4706.

    PubMed  CAS  Google Scholar 

  84. Scotet, E., David-Ameline, J., Peyrat, M-A., Moreau-Aubry, A., Pinczon, D., Lim, A., et al. (1996) T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis. J. Exp. Med. 184, 1791–1800.

    PubMed  CAS  Google Scholar 

  85. Hingorani, R., Choi, I-H., Akolka, P., Gulwani-Akolkar, B., Pergolizzi, R., Silver, J., et al. (1993) Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects}. J. Immunol. 151, 5762–5769.

    PubMed  CAS  Google Scholar 

  86. Posnett, D. N., Sinha, R., Kabak, S., and Russo, C. (1994) Clonal populations of T cells in normal elderly humans: the T cell equivalent to “Benign monoclonal gammapathy.’ J. Exp. Med. 179, 609–6

    PubMed  CAS  Google Scholar 

  87. Fitzgerald, J. E., Ricalton, N. S., Meyer, A. C., West, S. G., Kaplan, H., Behrendt, C., et al. (1995) Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J. Immunol. 154, 3538–3547.

    PubMed  CAS  Google Scholar 

  88. Brooks, E. G., Balk, S. P., Aupeix, K., Colonna, M., Strominger, J. L., and Groh-Spies, V. (1993) Human T-cell receptor (TCR) alpha/beta+ CD4−CD8” T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells. Proc. Natl. Acad. Sci. USA 90, 11787–11791.

    PubMed  CAS  Google Scholar 

  89. Hingorani, R., Monteiro, J., Furie, R., Chartash, E., Navarrete, C., Pergolizzi, R., et al. (1996) Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients. J. Immunol. 156, 852–858.

    PubMed  CAS  Google Scholar 

  90. Grunewald, J., Jeddi-Tehrani, M., Der Simonian, H., Andersson, R., and Wigzell, H. (1992) A persistent expansion in the peripheral blood of a normal adult male: a new clinical entity? Clin. Exp. Immunol. 89, 279–284.

    PubMed  CAS  Google Scholar 

  91. Morley, J. K., Batliwalla, F. M., Hingorani, R., and Gregersen, P.K. (1995) Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset. J. Immunol. 154, 6182–6190.

    PubMed  CAS  Google Scholar 

  92. Azuma, M., Phillips, J. H., and Lanier, L. L. (1993) CD28” T lymphocytes. Antigenic and functional properties. J. Immunol. 150, 1147–1159.

    PubMed  CAS  Google Scholar 

  93. Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., and Van Lier, R.A.W. (1997) Phenotypical and functional separation of memory and effector human CD8pos T cells. J. Exp. Med, in press.

    Google Scholar 

  94. Autran, B., Leblond, V., Sadat-Sowti, B., Lefranc, E., Got, P., Sutton, L., et al. (1991) A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis. Blood 77, 2237–2241.

    PubMed  CAS  Google Scholar 

  95. Wang, E. C., Lehner, P. J., Graham, S., and Borysiewicz, L. K. (1994) CD8high (CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines. Eur. J. Immunol. 24, 2903–2909.

    PubMed  CAS  Google Scholar 

  96. Wang, E. C., Moss, P. A., Frodsham, P., Lehner, P. J., Bell, J. I., and Borysiewicz, L. K. (1995) CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J. Immunol. 155, 5046–5056.

    PubMed  CAS  Google Scholar 

  97. Gorochov, G., Debre, P., Leblond, V., Sadat-Sowti, B., Sigaux, F., and Autranj, B. (1994) Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation. Blood 83, 587–595.

    PubMed  CAS  Google Scholar 

  98. Prince, H. E. and Jensen, E. R. (1991) Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection. J. Acquir. Immune Defic. Syndr. 4, 1227–1232.

    PubMed  CAS  Google Scholar 

  99. DerSimonian, H., Band, H., and Brenner, B. M. (1991) Increased frequency of T cell receptor V-alpha 12.1 expression on CD8+ T cells: evidence that V-alpha participates in shaping the peripheral T cell repertoire. J. Exp. Med. 174, 639–648.

    PubMed  CAS  Google Scholar 

  100. Candeias, S., Waltzinger, C., Benoist, C., and Mathis, D. (1991) The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells. J. Exp. Med. 174, 989–1000.

    PubMed  CAS  Google Scholar 

  101. Moss, P. A. and Bell, J. I. (1996) Comparative sequence analysis of the human T cell receptor TCRA and TCRB CDR3 regions. Hum. Immunol. 48, 32–38.

    PubMed  CAS  Google Scholar 

  102. Moss, P. A. and Bell, J. I. (1995) Sequence analysis of the human alpha beta T-cell receptor CDR3 region. Immunogenetics 42, 10–18.

    PubMed  CAS  Google Scholar 

  103. Li, Y., Sun, G. R., Tumang, J. R., Crow, M. K., and Friedman, S.M. (1994) CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response. J. Clin. Invest. 94, 2525–2531.

    PubMed  CAS  Google Scholar 

  104. Alam, A., Lambert, N., Lule, J., Coppin, H., Mazieres, B., De Preval, C., et al. (1996) Persistence of dominant T cell clones in synovial tissues during rheumatoid arthritis. J. Immunol. 156, 3480–3485.

    PubMed  CAS  Google Scholar 

  105. Yoon, J. W., Austin, M., Onodera, T., and Notkins, A.L. (1979) Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N. Engl. J. Med. 300, 1173–1179.

    PubMed  CAS  Google Scholar 

  106. Eggers, H. J. and Mertens, T. (1986) Persistence of Coxsackie B virus-specific IgM [letter]. Lancet 2, 284.

    PubMed  CAS  Google Scholar 

  107. Kurtzman, G. J., Cohen, B., Meyers, P., Amunullah, A., and Young, N.S. (1988) Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia. Lancet 2, 1159–1162.

    PubMed  CAS  Google Scholar 

  108. Saal, J. G., Steidle, M., Einsele, H., Muller, C. A., Fritz, P., and Zacher, J. (1992) Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis. Rheumatol. Int. 12, 147–151.

    PubMed  CAS  Google Scholar 

  109. Foto, F., Saag, K. G., Scharosch, L. L., Howard, E. J., and Naides, S. J. (1993) Parvovirus B19-specific DNA in bone marrow from B19 arthropathy patients: evidence for B19 virus persistence. J. Infect. Dis. 167, 744–748.

    PubMed  CAS  Google Scholar 

  110. Simpson, R. W., McGinty, L., Simon, L., Smith, C. A., Godzeski, C. W., and Boyd, R. J. (1984) Association of parvoviruses with rheumatoid arthritis of humans. Science 223, 1425–1428.

    PubMed  CAS  Google Scholar 

  111. Simpson, R. W., Van Leeuwen, D., Zazra, J. J., et al. (1985) Biological and molecular properties of the RA-1 parvoviruses. Parvovirus Workshop, Bern, Switz. (Abstract).

    Google Scholar 

  112. Hasunuma, T., Sumida, T., and Nishioka, K. (1997) Human T cell leukemia virus type-1 and rheumatoid arthritis. Int. Rev. Immunol, in press.

    Google Scholar 

  113. Nakajima, T., Aono, H., Hasunuma, T., Yamamoto, K., Maruyama, I., Nosaka, T., et al. (1993) Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene. J. Clin. Invest. 92, 186–193.

    PubMed  CAS  Google Scholar 

  114. Iwakura, Y., Tosu, M., Yoshida, E., Takiguchi, M., Sato, K., Kitajima, I., et al. (1991) Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science 253, 1026–1028.

    PubMed  CAS  Google Scholar 

  115. di Giovine, F.S., Bailly, S., Bootman, J., Almond, N., and Duff, G.W. (1994) Absence of lentiviral and human T cell leukemia viral sequences in patients with rheumatoid arthritis. Arthritis Rheum. 37, 349–358.

    PubMed  CAS  Google Scholar 

  116. Ferraro, A. S. and Newkirk, M. M. (1993) Correlative studies of rheumatoid factors and anti-viral antibodies in patients with rheumatoid arthritis. Clin. Exp. Immunol. 92, 425–431.

    PubMed  CAS  Google Scholar 

  117. Tsai, Y. T., Chiang, B. L., Kao, Y. F., and Hsieh, K. H. (1995) Detection of Epstein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. Int. Arch. Allergy. Immunol. 106, 235–240.

    PubMed  CAS  Google Scholar 

  118. Tsuchiya, N., Murayama, T., Yoshinoya, S., Matsuta, K., Shiota, M., Furukawa, T., et al. (1993) Antibodies to human cytomegalovirus 65-kilodalton Fc binding protein in rheumatoid arthritis: idiotypic mimicry hypothesis of rheumatoid factor production. Autoimmunity 15, 39–48.

    PubMed  CAS  Google Scholar 

  119. Tamm, A., Ziegler, T., Lautenschlager, I., Nikkari, S., Mottonen, T., Luukkainen, R., et al. (1993) Detection of cytomegalovirus DNA in cells from synovial fluid and peripheral blood of patients with early rheumatoid arthritis. J. Rheumatol 20, 1489–1493.

    PubMed  CAS  Google Scholar 

  120. Kondo, K., Kaneshima, H., and Mocarski, E. S. (1994) Human cytomegalovirus latent infection of granulocyte-macrophage progenitors. Proc. Natl. Acad. Sci. USA 91, 11879–11883.

    PubMed  CAS  Google Scholar 

  121. Maciejewski, J. P., Bruening, E. E., Donahue, R. E., Mocarski, E. S., Young, N. S., and St Jeor, S. C. (1992) Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood 80, 170–178.

    PubMed  CAS  Google Scholar 

  122. Decker, L. L., Klaman, L. D., and Thorley-Lawson, D. A. (1996) Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals. J. Virol. 70, 3286–3289.

    PubMed  CAS  Google Scholar 

  123. Inoue, N., Harada, S., Miyasaka, N., Oya, A., and Yanagi, K. (1991) Analysis of antibody titers to Epstein-Barr virus nuclear antigens in sera of patients with Sjogren’s syndrome and with rheumatoid arthritis. J. Infect. Dis. 164, 22–28.

    PubMed  CAS  Google Scholar 

  124. Tosato, G., Steinberg, A. D., Yarchoan, R., Heilman, C. A., Pike, S. E., De Seau, V., et al. (1984) Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. J. Clin. Invest. 73, 1789–1795.

    PubMed  CAS  Google Scholar 

  125. Yao, Q. Y., Rickinson, A. B., Gaston, J. S., and Epstein, M. A. (1986) Disturbance of the Epstein-Barr virus-host balance in rheumatoid arthritis patients: a quantitative study. Clin. Exp. Immunol. 64, 302–310.

    PubMed  CAS  Google Scholar 

  126. Zhang, L., Nikkari, S., Skurnik, M., Ziegler, T., Luukkainen, R., Mottonen, T., et al. (1993) Detection of herpesviruses by polymerase chain reaction in lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 36, 1080–1086.

    PubMed  CAS  Google Scholar 

  127. Takei, M., Mitamura, K., Fujiwara, S., Horie, T., Ryu, J., Osaka, S., et al. (1997) Detection of Epstein-Barr virus-encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients. Intern. Immunol. 9, 739–743.

    CAS  Google Scholar 

  128. Koide, J., Takada, K., Sugiura, M., Sekine, H., Ito, T., Saito, K., et al. (1997) Spontaneous establishment of an Epstein-Barr virus infected fibroblast line from the synovial tissue of a rheumatoid arthritis patient. J. Virol. 71, 2478–2481.

    PubMed  CAS  Google Scholar 

  129. Berneman, Z. N., Ablashi, D. V., Li, G., Eger-Fletcher, M., Reitz, M. S. J., Hung, C-L., et al. (1992) Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomega-lovirus. Proc. Natl. Acad. Sci. USA 89, 10552–10556.

    PubMed  CAS  Google Scholar 

  130. Mesri, E. A., Cesarman, E., Arvanitkais, L., Rafii, S., Moore, M. A. S.. Posnett, D. N., et al. (1996) Human Herpesvirus-8/Kaposi’s sarcoma associated herpes virus (HHV8/KSHV) is a new transmissible virus that infects B-cells. J. Exp. Med. 183, 2385–2390.

    CAS  Google Scholar 

  131. Newkirk, M. M., Watanabe Duffy, K. N., Leclerc, J., Lambert, N., and Shiroky, J. B. (1994) Detection of cytomegalovirus, Epstein-Barr virus and herpes virus-6 in patients with rheumatoid arthritis with or without Sjögren’s syndrome. Br. J. Rheumatol. 33, 317–322.

    PubMed  CAS  Google Scholar 

  132. Walser-Kuntz, D. R., Weyand, C. M., Weaver, A. J., O’Fallon, W. M., and Goronzy, J. J. (1995) Mechanisms underlying the formation of T cell receptor repertoire in rheumatoid arthritis. Immunity 2, 597–605.

    PubMed  CAS  Google Scholar 

  133. Paliard, X., West, S. G., Lafferty, J. A., Clements, J. R., Kappler, J. W., Marrack, P., et al. (1991) Evidence for the effects of a superantigen in Rheumatoid Arthritis. Science 253, 325–329.

    PubMed  CAS  Google Scholar 

  134. Howell, M. D., Diveley, J. P., Lundeen, K. A., Esty, A., Winters, S. T., Carlo, D. J., et al. (1991) Limited T-cell receptor beta chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 88, 10921–10925.

    PubMed  CAS  Google Scholar 

  135. Williams, W. V., Kieber-Emmons, T., Fang, Q., Von Feldt, J., Wang, B., Ramanujam, T., et al. (1993) Conserved motifs in rheumatoid arthritis synovial tissue T-cell receptor beta chains. DNA Cell Biol. 12, 425–434.

    PubMed  CAS  Google Scholar 

  136. Sottini, A., Imberti, L., Gorla, R., Cattaneo, R., and Primi, D. (1991) Restricted expression of T cell receptor Vβ but not Vα genes in rheumatoid arthritis. Eur. J. Immunol. 21, 461–466.

    PubMed  CAS  Google Scholar 

  137. Grom, A. A., Thompson, S. D., Luyrink, L., Passo, M. Choi, E., and Glass, D. N. (1993) Dominant T-cell receptor beta chain variable region Vbeta 14+ clones in juvenile rheumatoid arthritis. Proc. Natl. Acad. Sci. USA. 90, 11104–11108.

    PubMed  CAS  Google Scholar 

  138. Schmidt, D., Martens, P. B., Weyand, C. M., and Goronzy, J. J. (1996) The repertoire of CD4+ CD28-T cells in rheumatoid arthritis. Mol. Med. 2, 608–618.

    PubMed  CAS  Google Scholar 

  139. Monteiro, J., Hingorani, R., Choi, I. H., Pergolizzi, R., Silver, J., and Gregersen, P. K. (1995) Variability in CD8+ T-cell oligoclonality patterns in monozygotic twins. Ann. NY Acad. Sci. 756, 96–98.

    PubMed  CAS  Google Scholar 

  140. Gonzalez-Quintial, R., Baccala, R., Pope, R. M., and Theofilopoulos, A.N. (1996) Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J. Clin. Invest. 97, 1335–1343.

    PubMed  CAS  Google Scholar 

  141. Sottini, A., Imberti, L., Bettinardi, A., Mazza, C., Gorla, R., and Primi, D. (1993) Selection of T lymphocytes in two rheumatoid arthritis patients defines different T-cell receptor V beta repertoires in CD4+ and CD8+ T-cell subsets. J. Autoimmun. 6, 621–637.

    PubMed  CAS  Google Scholar 

  142. Lunardi, C., Marguerie, C., and So, A. K. (1992) An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes. Clin. Exp. Immunol. 90, 440–446.

    PubMed  CAS  Google Scholar 

  143. Pluschke, G., Ginter, A., Taube, H., Melchers, I., Peter, H. H., and Krawinkel, U. (1993) Analysis of T cell receptor V beta regions expressed by rheumatoid synovial T lymphocytes. Immunobiology 188, 330–339.

    PubMed  CAS  Google Scholar 

  144. Struyk, L., Hawes, G. E., Mikkers, H. M. L., Tak, P. P., Breedveld, F. C., and van den Elsen, P. J. (1996) Molecular analysis of the T-cell receptor beta-chain repertoire in early rheumatoid arthritis: heterogeneous TCRBV gene usage with shared amino acid profiles in CDR3 regions of T lymphocytes in multiple synovial tissue needle biopsies from the same joint. Eur. J. Clin. Invest. 26, 1092–1102.

    PubMed  CAS  Google Scholar 

  145. Struyk, L., Kurnick, J. T., Hawes, J. E., van Laar, J. M., Schipper, R., Oksenberg, J. R., et al. (1993) T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. Hum. Immunol. 37, 237–251.

    PubMed  CAS  Google Scholar 

  146. Yamamoto, K., Sakoda, H., Nakajima, T., Kato, T., Okubo, M., Dohi, M., et al. (1992) Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int. Immunol. 4, 1219–1223.

    PubMed  CAS  Google Scholar 

  147. Ikeda, Y., Masuko, K., Nakai, Y., Kato, T., Hasanuma, T., Yoshino, S.I., et al. (1996) High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses. Arthritis Rheum. 39, 446–453.

    PubMed  CAS  Google Scholar 

  148. Zagon, G., Tumang, J. R., Li, Y., Friedman, S. M., and Crow, M. K. (1994) Increased frequency of Vβ17-positive T cells in patients with rheumatoid arthritis. Arthritis Rheum.. 37, 1431–1440.

    PubMed  CAS  Google Scholar 

  149. Alam, A., Lule, J., Coppin, H., Lambert, N., Mazieres, B., De Preval, C., et al. (1995) T-cell receptor variable region of the beta-chain gene use in peripheral blood and multiple synovial membranes during rheumatoid arthritis. Hum. Immunol. 42, 331–339.

    PubMed  CAS  Google Scholar 

  150. Maruyama, T., Saito, I., Miyake, S., Hashimoto, H., Sato, K., Yagita, H., et al. (1993) A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis. Eur. J. Immunol. 23, 2059–2065.

    PubMed  CAS  Google Scholar 

  151. Broker, B. M., Korthauer, U., Heppt, P., Weseloh, G., de la Camp, R., Kroczek, R. A., et al. (1993) Biased T cell receptor V gene usage in rheumatoid arthritis. Oligoclonal expansion of T cells expressing V alpha 2 genes in synovial fluid but not in peripheral blood. Arthritis Rheum. 36, 1234–1243.

    PubMed  CAS  Google Scholar 

  152. Der Simonian, H., Sugita, M., Glass, D.N., Maier, A. L., Weinblatt, M. E., Reme, T., et al. (1993) Clonal Vα12.1 T cell expansions in the peripheral blood of rheumatoid arthritis patients. J. Exp. Med. 177, 1623–1631.

    Google Scholar 

  153. Pluschke, G., Ricken, G., Taube, H., Kroninger, S., Melchers, I., Peter, H. H., et al. (1991) Biased T cell receptor V alpha region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur. J. Immunol. 21, 2749–2754.

    PubMed  CAS  Google Scholar 

  154. Bucht, A., Oksenberg, J. R., Lindblad, S., Gronberg, A., Steinman, L., and Klareskog, L. (1992) Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand. J. Immunol. 35, 159–165.

    PubMed  CAS  Google Scholar 

  155. Doherty, P. J., Inman, R. D., Laxer, R. M., Silverman, E. D., Yang, S. X., Suurmann, I., et al. (1996) Analysis of T cell receptor gamma transcripts in right and left knee synovial fluids of patients with rheumatoid arthritis. J. Rheumatol. 23, 1143–1150.

    PubMed  CAS  Google Scholar 

  156. Reme, T., Portier, M., Frayssinoux, F., Combe, B., Miossec, P., Favier, F., et al. (1990) T cell receptor expression and activation of synovial lymphocyte subsets in patients with rheumatoid arthritis: phenotyping of multiple synovial sites. Arthritis Rheum. 33, 485–492.

    PubMed  CAS  Google Scholar 

  157. Jacobs, M. R. and Haynes, B. F. (1992) Increase in TCR gamma delta T lymphocytes in synovia from rheumatoid arthritis patients with active synovitis. J. Clin. Immunol. 12, 130–138.

    PubMed  CAS  Google Scholar 

  158. Meliconi, R., Uguccioni, M., D’Errico, A., Cassisa, A., Frizziero, L., and Facchini, A. (1992) T-cell receptor gamma-delta positive lymphocytes in synovial membrane. Br. J. Rheumatol. 31, 59–61.

    PubMed  CAS  Google Scholar 

  159. Olive, C., Gatenby, P. A., and Serjeantson, S. W. (1992) Molecular characterization of the V gamma 9 T cell receptor repertoire expressed in patients with rheumatoid arthritis. Eur. J. Immunol. 22, 2901–2906.

    PubMed  CAS  Google Scholar 

  160. Olive, C., Gatenby, P. A., and Serjeantson, S. W. (1992) Evidence for oligoclonality of T cell receptor delta chain transcripts expressed in rheumatoid arthritis patients. Eur. J. Immunol. 22, 2587–2593.

    PubMed  CAS  Google Scholar 

  161. Struyk, L., Hawes, G. E., Dolhain, R.J., van Scherpenzeel, A., Godthelp, B., Breedveld, F. C., et al. (1994) Evidence for selective in vivo expansion of synovial tissue-infiltrating CD4+ CD45RO+ T lymphocytes on the basis of CDR3 diversity. Int. Immunol. 6, 897–907.

    PubMed  CAS  Google Scholar 

  162. Imberti, L., Sottini, A., Signorini, S., Gorla, R., and Primi D. (1997) Oligoclonal CD4+ CD57+ T-cell expansions contribute to the imbalanced T-cell receptor repertoire of rheumatoid arthritis patients. Blood 89, 2822–2832.

    PubMed  CAS  Google Scholar 

  163. Dupuy, A., Monier, S., Jorgensen, C., Gao, Q., Travaglio-Encinoza, A., Bologna, C., et al. (1993) Increased percentage of CD3+, CD57+ lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease [see comments]. Arthritis Rheum. 36, 608–612.

    Google Scholar 

  164. Burns, C. M., Tsai, V., and Zvaifler, N. J. (1992) High percentage of CD8+, Leu7+ cells in rheumatoid arthritis synovial fluid. Arthritis Rheum. 35, 865–873.

    PubMed  CAS  Google Scholar 

  165. Travaglio-Encinoza, A., Chaouni, I., Der Simonian, H., Jorgensen, C., Simony-Lafontaine, J., Romagne, F., et al. (1995) T cell receptor distribution in rheumatoid synovial follicles. J. Rheumatol. 22, 394–399.

    PubMed  CAS  Google Scholar 

  166. Olive, C., Gatenby, P. A., and Serjeantson, S. W. (1994) Persistence of gamma/ delta T cell oligoclonality in the peripheral blood of rheumatoid arthritis patients. Immunol. Cell Biol. 72, 7–11.

    PubMed  CAS  Google Scholar 

  167. Khazaei, H. A., Lunardi, C., and So, A. K. (1995) CD4 T cells in the rheumatoid joint are oligoclonally activated and change during the course of disease. Ann. Rheum. Dis. 54, 314–317.

    PubMed  CAS  Google Scholar 

  168. Maurice, M. M., Res, P. C., Leow, A., van Hall, T., Daha, M. R., Struyk, L., et al. (1995) Joint-derived T cells in rheumatoid arthritis proliferate to antigens present in autologous synovial fluid. Scand. J. Rheumatol. Suppl. 101, 169–177.

    PubMed  CAS  Google Scholar 

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Authors
  1. James W. Edinger
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  2. David N. Posnett
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  1. Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, TX, USA

    Sudhir Paul

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Edinger, J.W., Posnett, D.N. (1999). T-Cell Antigen Receptor Repertoire in Rheumatoid Arthritis. In: Paul, S. (eds) Autoimmune Reactions. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1610-0_9

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