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Autoimmune Reactions pp 383–394Cite as

Mechanisms of Action of Intravenous Immunoglobulin (IVIg) in Immune-Mediated Diseases

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Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

Intravenous immunoglobulin (IVIg) for therapeutic use is normal poly-specific immunoglobulin-G prepared from plasma pools of large numbers of healthy donors. The fundamental characteristics of immunoglobulin preparations relevant to their immunomodulatory and anti-inflammatory properties include 1) an intact Fc portion, which allows for appropriate interactions of IVIg with serum proteins (e.g., complement components) and with Fcγ receptors, 2) a relative distribution of IgG subclasses in the IVIg preparation that is similar to the distribution found in normal serum, 3) a normal half-life of the infused IgG in recipients, and 4) a large number of binding sites (variable regions) of antibodies, as a consequence of pooling IgG of several thousands of donors in IVIg. Thus, the broad spectrum of antibody reactivities present in IVIg comprises antibodies to pathogens and foreign antigens, and antibodies to self antigens (“natural autoantibodies”) which are normally present in human serum, including antibodies to the idiotypes of immunoglobulins. As discussed later, anti-idiotypic antibodies in IVIg that are directed against autoantibodies are directly relevant to the immunoregulation of autoimmune disease.

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Authors
  1. K. A. Nagendra Prasad
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  2. Michel D. Kazatchkine
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  3. Srinivas V. Kaveri
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, TX, USA

    Sudhir Paul

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© 1999 Springer Science+Business Media New York

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Prasad, K.A.N., Kazatchkine, M.D., Kaveri, S.V. (1999). Mechanisms of Action of Intravenous Immunoglobulin (IVIg) in Immune-Mediated Diseases. In: Paul, S. (eds) Autoimmune Reactions. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1610-0_24

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  • DOI: https://doi.org/10.1007/978-1-4612-1610-0_24

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7215-1

  • Online ISBN: 978-1-4612-1610-0

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