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Kidney Damage in Autoimmune Disease

  • Chapter
Autoimmune Reactions

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

In 1641, Daniel Sennet noted the association of scarlatina and dropsy (1), but it was not until 40 years ago that Mellors first demonstrated in human kidney biopsies the deposition in the glomerulus of gamma globulins (2). Since that time, there has been a tremendous amount of work, both experimental and clinical, demonstrating that the kidney is an important site of injury in autoimmune disease. In systemic lupus erythematous, the prototypic autoimmune disorder, the kidney is the organ most commonly affected. By kidney biopsy, at least mild abnormalities are seen in all patients with lupus.

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  1. Gerald C. Groggel
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  1. Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, TX, USA

    Sudhir Paul

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Groggel, G.C. (1999). Kidney Damage in Autoimmune Disease. In: Paul, S. (eds) Autoimmune Reactions. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1610-0_17

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  • DOI: https://doi.org/10.1007/978-1-4612-1610-0_17

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