Skip to main content
SpringerLink
Log in

Dysregulation of the Idiotype Network in Autoimmune Diseases

  • Chapter
Book cover Autoimmune Reactions

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

The hallmark of autoimmune disorders is the presence of serologically detectable autoantibodies. The appearance of autoantibodies in patients is tacitly assumed to reflect the acquisition of new antibody activities. However, it is now well recognized that some autoantibodies are also present in healthy individuals (1). Recent evidence suggests that their expression may be regulated by an idiotype network (2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Avrameas, S. (1991) Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton.’ Immunol. Today 12, 154–1

    PubMed  CAS  Google Scholar 

  2. Jerne, N. K. (1974) Towards a network theory of the immune system. Ann. Immunol. 125C, 373

    CAS  Google Scholar 

  3. Nasu, H., Chia, D. S., Knutson, D. W., and Barnett, E. V. (1980) Naturally occurring human antibodies to the F(ab’)2 portion of IgG. Clin. Exp. Immunol. 42, 378–386.

    PubMed  CAS  Google Scholar 

  4. Silvestris, F., Bankhurst, A. D., Searles, R. P., and Williams, R. C., Jr. (1984) Studies of anti-F(ab’)2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus. Arthritis Rheum. 27, 1387–1396.

    Article  PubMed  CAS  Google Scholar 

  5. Osterland, C. K., Harboe, M., and Kunkel, H. G. (1963) Anti-γ-globulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies. Vox Sanguinis 8, 133–152.

    Article  PubMed  CAS  Google Scholar 

  6. Harboe, M., Rau, B., and Aho, K. (1965) Properties of various anti-γ-globulin factors in human sera. J. Exp. Med. 121, 503–519.

    Article  PubMed  CAS  Google Scholar 

  7. Natvig, J. B. (1966) Heterogeneity of anti-gamma-globulin factors detected by pepsin-digested human gamma G-globulin. Acta. Pathol. Microbiol. Scand. 66, 369–382.

    PubMed  CAS  Google Scholar 

  8. Silvestris, F., Williams, R. C., Jr., and Searles, R. P. F (1986) Human anti-F(ab’)2 antibodies and pepsin agglutinators react with Fv determinants. Scand J. Immunol. 23, 499–508.

    Article  PubMed  CAS  Google Scholar 

  9. Yancey, W. B., Jr., Silvestris, F., Conlon, M., Rodriguez, M., Malone, C., and Williams, R. C., Jr. (1992) Human anti-F(ab’)2 antibodies show preferential reactivity for F(ab’)2 molecules bearing lambda light chains. Clin. Immunol. Immunopath. 65, 176–182.

    Article  CAS  Google Scholar 

  10. Williams, R. C., Jr., Malone, C. C., Silvestris, F., and Solomon, A. (1995) Molecular localization of human IgG anti-F(ab’)2 reactivity with variable-and constant-region lambda light-chain epitopes. J. Clin. Immunol. 15, 349–362.

    Article  PubMed  CAS  Google Scholar 

  11. Williams, R. C., Jr., Malone, C. C., and Silvestris, F. (1996) Shared V-region antigens and cross-reacting specificities of human IgG anti-F(ab’)2 and anti-DNA antibodies. Clin. Immunol. Immunopath. 80, 194–203.

    Article  CAS  Google Scholar 

  12. Weinberger, J. Z., Germain, R. N., Ju, S. T., Greene, M. I., Benacerraf, B., and Dorf, M. E. (1979) Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J. Exp. Med. 150, 761–776.

    Article  PubMed  CAS  Google Scholar 

  13. Bona, C. and Paul, W.E. (1979) Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J. Exp. Med. 149, 592–600.

    Article  PubMed  CAS  Google Scholar 

  14. Binz, H. and Wigzell, H. (1976) Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. V. Biochemical and serological characteristics of naturally occurring, soluble antigen-binding T-lym-phocyte-derived molecules. Scand. J. Immunol. 5, 559–571.

    Article  PubMed  CAS  Google Scholar 

  15. Robertson, M. (1977) Immunoglobulin genes and the immune response. Nature 269, 648–650.

    Article  PubMed  CAS  Google Scholar 

  16. Woodland, R. and Cantor, H. (1978) Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody. Eur. J. Immunol. 8, 600–606.

    Article  PubMed  CAS  Google Scholar 

  17. Schrater, A. F., Goidl, E. A., Thorbecke, G. J., Siskind, G. W. (1979) Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells. J. Exp. Med. 150, 138–153.

    Article  PubMed  CAS  Google Scholar 

  18. Bankert, R. B. and Pressman D. (1976) Receptor-blocking factor present in immune serum resembling auto-anti-idiotype antibody. J. Immunol. 117, 457–462.

    PubMed  CAS  Google Scholar 

  19. Geha, R. S. (1982) Presence of auto-anti-idiotypic antibody during the normal human immune response to tetanus toxoid antigen. J. Immunol. 129, 139–144.

    PubMed  CAS  Google Scholar 

  20. Arreaza, E. E., Gibbons, J. J., Jr., Siskind, G. W., and Weksler, M. E. (1993) Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans. Clin. Exp. Immunol. 92, 169–173.

    Article  PubMed  CAS  Google Scholar 

  21. Kobayashi, K., Ueno, Y., Suzuki, H., Miura, M., Nagatomi, R., Ishii, M., et al. (1994) Anti-idiotypic antibody production in hepatitis B vaccine recipients. J. Gastroenterol. 29, 740–744.

    Article  PubMed  CAS  Google Scholar 

  22. Hahn-Zoric, M., Carlsson, B., Jeansson, S., Ekre, H. P., Osterhaus, A. D., Roberton, D., et al. (1993) Anti-idiotypic antibodies to poliovirus antibodies in commercial immunoglobulin preparations, human serum, and milk. Ped. Res. 33, 475–480.

    Article  CAS  Google Scholar 

  23. Mellander, L., Carlsson, B., and Hanson, L.A. (1986) Secretory IgA and IgM antibodies to E. coli O and poliovirus type I antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of anti-idiotypic induction? Clin. Exp. Immunol. 63, 555–5

    PubMed  CAS  Google Scholar 

  24. Casiglia, D., Triolo, G., and Giardina, E. (1991) IgG auto-anti-idiotype antibodies against antibody to insulin in insulin-dependent (type 1) diabetes mellitus. Detection by capture enzyme linked immunosorbent assay (ELISA) and relationship with anti-insulin antibody levels. Diabetes Res. 16, 181–184.

    PubMed  CAS  Google Scholar 

  25. Rose, L. M., Goldman, M., and Lambert, P. H. (1982) Simultaneous induction of an idiotype, corresponding anti-idiotypic antibodies, and immune complexes during African trypanosomiasis in mice. J. Immunol. 128, 79–85.

    PubMed  CAS  Google Scholar 

  26. Hassan, J., Feighery, C., Bresnihan, B., and Whelan, A. (1992) Prevalence of anti-Fab antibodies in patients with autoimmune and infectious diseases. Clin. Exp. Immunol. 89, 423–426.

    Article  PubMed  CAS  Google Scholar 

  27. Troisi, C. L. and Hollinger, F. B. (1985) Detection of an IgM antiidiotype directed against anti-HBs in hepatitis B patients. Hepatology 5, 758–762.

    Article  PubMed  CAS  Google Scholar 

  28. Kobayashi, K., Suzuki, H., Ueno, Y., Nagatomi, R., Kanno, A., Otsuki, M., et al. (1990) Anti-idiotypic antibodies directed against anti-HBs among the patients with chronic hepatitis B. Tohoku J. Exp. Med. 161, 261–271.

    Article  PubMed  CAS  Google Scholar 

  29. Geltner, D., Franklin, E. C., and Frangione, B. (1980) Antiidiotypic activity in the IgM fractions of mixed cryoglobulins. J. Immunol. 125, 1530–1535.

    PubMed  CAS  Google Scholar 

  30. Lebo, D. B., Ilowite, N. T., Sood, S., et al. (1993) Anti-idiotypic antibodies (ab2) are present in pediatric lyme arthritis (LA) sera for all Borrelia burgdorferi (BB) antigens except OSP-A and OSP-B. (Abstract) Arthritis Rheum. 36, S1

    Google Scholar 

  31. Bergenbrant, S., Yi, Q., Osby, E., Osterborg, A., Ostman, R., Bjorkholm, M., et al., (1994) Anti-idiotypic B lymphocytes in patients with monoclonal gammopathies. Scand J. Immunol. 40, 216–220.

    Article  PubMed  CAS  Google Scholar 

  32. Keshgegian, A. A. and Sevin, P. (1979) Waidenstrom’s macroglobulinemia associated with a mixed cryoglobulin. Report of a case with partial precipitation in vitro at 37 degrees C. Arch. Path. Lab. Med. 103, 270–273.

    PubMed  CAS  Google Scholar 

  33. Carini, C. and Brostoff, J. (1983) An antiglobulin: IgG anti-IgE. Occurrence and specificity. Ann. Allergy 51, 251–254.

    PubMed  CAS  Google Scholar 

  34. Vassella, C. C., de Weck, A. L., and Stadler, B. M. (1990) Natural anti-IgE auto-antibodies interfere with diagnostic IgE determination. Clin. Exp. Allergy 20, 295–303.

    Article  PubMed  CAS  Google Scholar 

  35. Magnusson, C. G. and Vaerman, J. P. (1986) Autoantibodies of the IgM class against a human myeloma protein IgE(DES). II. Specificity. Int. Arch. Allergy Applied Immunol. 79, 157–163.

    Article  CAS  Google Scholar 

  36. Magnusson, C. G. (1994) Naturally occurring human IgA autoantibodies against IgE-DES myeloma protein. Prevalence and specificity. Allergy 49, 820–826.

    Article  PubMed  CAS  Google Scholar 

  37. Hebert, J., Bernier, D., and Mourad, W. (1990) Detection of auto-anti-idiotypic antibodies to Lol p I (rye I) IgE antibodies in human sera by the use of murine idiotypes: levels in atopic and non-atopic subjects and effects of immunotherapy. Clin. Exp. Immunol. 80, 413–419.

    Article  PubMed  CAS  Google Scholar 

  38. Castracane, J. M. and Rocklin, R. E. (1988) Detection of human auto-anti-idiotypic antibodies (Ab2). II. Generation of Ab2 in atopic patients undergoing allergen immunotherapy. Int. Arch. Allergy Appl. Immunol. 86, 295–302.

    Article  PubMed  CAS  Google Scholar 

  39. Khan, R. H., Szewczuck, M. R., and Day, J. H. (1991) Bee venom anti-idiotypic antibody is associated with the protection in beekeepers and bee sting-sensitive patients receiving immunotherapy against allergic reaction. J. Allergy Clin. Immunol. 88, 199–208.

    Article  PubMed  CAS  Google Scholar 

  40. Reed, E., Hardy, M., Benvenisty, A., Lattes, C., Brensilver, J., McCabe, R., et al. (1987) Effect of antiidiotypic antibodies to HLA on graft survival in renal-allograft recipients. N. Engl. J. Med. 316, 1450–1455.

    Article  PubMed  CAS  Google Scholar 

  41. Reed, E., Cohen, D. J., Barr, M. L., Ho, E., Marboe, C. C., Rose, E. A., et al. (1992) Effect of anti-HLA and anti-idiotypic antibodies on the long-term survival of heart and kidney allografts. Transplant. Proc. 24, 2494–2495.

    PubMed  CAS  Google Scholar 

  42. Chauhan, B., Phelan, D. L., Marsh, J. W., and Mohanakumar, T. (1993) Characterization of antiidiotypic antibodies to donor HLA that develop after liver transplantation. Transplantation 56, 443–448.

    Article  PubMed  CAS  Google Scholar 

  43. Chia, D., Horimi, T., Terasaki, P. I., and Hermes, M. (1982) Association of anti-Fab and anti-IgG antibodies with high kidney transplant survival. Transplant. Proc. 14, 322–324.

    PubMed  CAS  Google Scholar 

  44. Horimi, T., Chia, D., Terasaki, P. I., Ayoub, G., and Iwaki, Y. (1982) Association of anti-F(ab’)2 antibodies with higher kidney transplant survival rates. Transplantation 33, 603–605.

    Article  PubMed  CAS  Google Scholar 

  45. Feduska, N. J., Jr., Chia, D., Terasaki, P. I., and Sugich, L. (1991) Effect of anti-Fab antibodies on renal allografts. Transplant. Proc. 23, 1277–1278.

    PubMed  Google Scholar 

  46. Susal, C., Groth, J., Tanzi-Fetta, R. F., Kirste, G., Doerr, C., Terness, P., et al. (1992) Characterization of protective anti-Fab autoantibodies in kidney graft recipients. Transplant. Proc. 24, 2523–2526.

    PubMed  CAS  Google Scholar 

  47. Terness, P., Navolan, D., Moroder, L., Siedler, F., Weyher, E., Kohl, I., et al. (1996) A natural IgA-anti-F(ab’)2γ autoantibody occurring in healthy individuals and kidney graft recipients recognizes an IgG1 hinge region epitope. J. Immunol. 157, 4251–4257.

    PubMed  CAS  Google Scholar 

  48. Agrawal, S., Sharma, R. K., Kishore, R., and Agarwal, S. S. (1994) Development of anti-idiotypic antibodies to HLA antigens during pregnancy. Indian J. Med. Res. 99, 42–46.

    PubMed  CAS  Google Scholar 

  49. Naz, R. K., Ahmad, K., and Menge, A. C. (1993) Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies. J. Clin. Invest. 92, 2331–2338.

    Article  PubMed  CAS  Google Scholar 

  50. Bartfeld, H. (1969) Distribution of rheumatoid factor activity in nonrheumatoid states. Ann. NY Acad. Sci. 168, 30–40.

    Article  PubMed  CAS  Google Scholar 

  51. Svec, K. H. and Veit, B. C. (1967) Age-related antinuclear factors: immunologic characteristics and associated clinical aspects. Arthritis Rheum. 10, 509–516.

    Article  PubMed  CAS  Google Scholar 

  52. Silvestris, F., Anderson, W., Goodwin, J. S., and Williams, R. C., Jr. (1985) Discrepancy in the expression of autoantibodies in healthy aged individuals. Clin. Immunol. Immunopath. 35, 234–244.

    Article  CAS  Google Scholar 

  53. Lutz, H. U. and Wipf, G. (1982) Naturally occurring autoantibodies to skeletal proteins from human red blood cells. J. Immunol. 128, 1695–1699.

    PubMed  CAS  Google Scholar 

  54. Guilbert, B., Dighiero, G., and Avrameas, S. (1982) Naturally occurring antibodies against nine common antigens in human sera I. detection, isolation, and characterization. J. Immunol. 128, 2779–2787.

    PubMed  CAS  Google Scholar 

  55. Spitzer, R. E., Stitzel, A. E., and Tsokos, G. C. (1990) Human anti-idiotypic antibody responses to autoantibody against the alternative pathway C3 convertase. Clin. Immunol. Immunopath. 57, 19–31.

    Article  CAS  Google Scholar 

  56. Spitzer, R. E., Stitzel, A. E., and Tsokos, G. C. (1992) Autoantibody to the alternative pathway C3/C5 convertase and its anti-idiotypic response. A study in affinity. J. Immunol. 148, 137–141.

    PubMed  CAS  Google Scholar 

  57. Tsokos, G. C., Stitzel, A. E., Patel, A. D., Hiramatsu, M., Balow, J. E., and Spitzer, R. E. (1989) Human polyclonal and monoclonal IgG and IgM complement 3 nephritic factors: evidence for idiotypic commonality. Clin. Immunol. Immunopath. 53, 113–122.

    Article  CAS  Google Scholar 

  58. Dietrich, G., Algiman, M., Sultan, Y., Nydegger, U. E., and Kazatchkine, M. D. (1992) Origin of anti-idiotypic activity against anti-factor VIII autoantibodies in pools of normal human immunoglobulin G (IVIg). Blood 79, 2946–2951.

    PubMed  CAS  Google Scholar 

  59. Gilles, J. G. and Saint-Remy, J. M. (1994) Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies. J. Clin. Invest. 94, 1496–1505.

    Article  PubMed  CAS  Google Scholar 

  60. Zouali, M. and Eyquern, A. (1983) Expression of anti-idiotypic clones against auto-anti-DNA antibodies in normal individuals. Cell. Immunol. 76, 137–147.

    Article  PubMed  CAS  Google Scholar 

  61. Silvestris, F., Searles, R. P., Bankhurst, A. D., and Williams, R. C. (1985) Family distribution of anti-F(ab’)2 antibodies in relatives of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 60, 329–338.

    PubMed  CAS  Google Scholar 

  62. Warrington, R. J., Wong, S. K., Ramdahin, S., and Rutherford, W. J. (1995) Normal human cord blood B cells can produce high affinity IgG antibodies to dsDNA that are recognized by cord blood-derived anti-idiotypic antibodies. Scand J. Immunol. 42, 397–406.

    Article  PubMed  CAS  Google Scholar 

  63. Buskila, D. and Shoenfeld, Y. (1992) From the practical viewpoint-immunomodulation with natural auto-anti-idiotypic antibodies: the role of treatment with intravenous immunoglobulins (IVIg) in Natural Autoantibodies: Their Physiological Role and Regulatory Significance (Shoenfeld, Y. and Isenberg, D. A., eds.), CRC, Boca Raton, FL, pp. 303–336.

    Google Scholar 

  64. Sultan, Y., Kazatchkine, M. D., Maisonneuve, P., and Nydegger, U. E. (1984) Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin. Lancet 2, 765–768.

    Article  PubMed  CAS  Google Scholar 

  65. Dietrich, G. and Kazatchkine, M. D. (1990) Normal immunoglobulin G (IgG) for therapeutic use (intravenous Ig) contain antiidiotypic specificities against an immunodominant, disease-associated, cross-reactive idiotype of human anti-thyroglobulin autoantibodies. J. Clin. Invest. 85, 620–625.

    Article  PubMed  CAS  Google Scholar 

  66. Rossi, F. and Kazatchkine, M. D. (1989) Antiidiotypes against autoantibodies in pooled normal human polyspecific Ig. J. Immunol. 143, 4104–4109.

    PubMed  CAS  Google Scholar 

  67. Tandon, N., Jayne, D. R., McGregor, A. M., and Weetman, A. P. (1992) Analysis of anti-idiotypic antibodies against anti-microsomal antibodies in patients with thyroid autoimmunity. J. Autoimmun. 5, 557–570.

    Article  PubMed  CAS  Google Scholar 

  68. Berchtold, P., Dale, G. L., Tani, P., and McMillan, R. (1989) Inhibition of autoantibody inding to platelet glycoprotein IIb/IIIa by anti-idiotypic antibodies in intravenous gammaglobulin. Blood 74, 2414–2417.

    PubMed  CAS  Google Scholar 

  69. Rossi, F., Jayne, D. R., Lockwood, C. M., and Kazatchkine, M. D. (1991) Antiidiotypes against anti-neutrophil cytoplasmic antigen autoantibodies in normal human polyspecific IgG for therapeutic use and in the remission sera of patients with systemic vasculitis. Clin. Exp. Immunol. 83, 298–303.

    Article  PubMed  CAS  Google Scholar 

  70. Pall, A. A., Varagunam, M., Adu, D., Smith, N., Richards, N. T., Taylor, C. M., et al. (1994) Anti-idiotypic activity against anti-myeloperoxidase antibodies in pooled human immunoglobulin. Clin. Exp. Immunol. 95, 257–262.

    Article  PubMed  CAS  Google Scholar 

  71. van Doom, P. A., Rossi, F., Brand, A., van Lint, M., Vermeulen, M., and Kazatchkine, M. D. (1990) On the mechanism of high-dose intravenous immunoglobulin treatment of patients with chronic inflammatory demyelinating polyneur-opathy. J. Neuroimmunol. 29, 57–64.

    Article  Google Scholar 

  72. Liblau, R., Gajdos, P., Bustarret, F. A., el Habib, R., Bach, J. F., and Morel, E. (1991) Intravenous gamma-globulin in myasthenia gravis: interaction with antiacetylcholine receptor autoantibodies. J. Clin. Immunol. 11, 128–131.

    Article  PubMed  CAS  Google Scholar 

  73. Caccavo, D., Vaccaro, F., Ferri, G. M., Amoroso, A., and Bonomo, L. (1994) Anti-idiotypes against antiphospholipid antibodies are present in normal polyspecific immunoglobulins for therapeutic use. J. Autoimmun. 7, 537–548.

    Article  PubMed  CAS  Google Scholar 

  74. Stafford, H. A., Anderson, C. J., Reichlin, M. (1995) Unmasking of anti-riboso-mal P autoantibodies in healthy individuals. J. Immunol. 155, 2754–2761.

    PubMed  CAS  Google Scholar 

  75. Pan, Z. J. and Stafford, H. A. (1996) Recombinant ribosomal P2 protein can unmask anti-ribosomal P autoantibodies from healthy adults. J. Lab. Clin. Med. 127, 333–339.

    Article  PubMed  CAS  Google Scholar 

  76. Terness, P., Marx, U., Sandilands, G., Roelcke, D., Welschof, M., and Opelz, G. (1993) Suppression of anti-erythrocyte autoantibody-producing B cells by a physiological IgG-anti-F(ab’)2 antibody and escape from suppression by tumour transformation; a model relevant for the pathogenesis of autoimmune haemolytic anaemia. Clin. Exp. Immunol. 93, 253–258.

    Article  PubMed  CAS  Google Scholar 

  77. Silvestris, F., Williams, R. C., Jr., Frassanito, M. A. and Dammacco, F. (1987) In vitro inhibition of anti-DNA producing cells from systemic lupus erythematosus patients by autologous anti-F(ab’)2 antibodies. Clin. Immunol. Immunopath. 42, 50–62.

    Article  CAS  Google Scholar 

  78. Evans, M. and Abdou, N. I. (1993) In vitro modulation of anti-DNA secreting peripheral blood mononuclear cells of lupus patients by anti-idiotypic antibody of pooled human intravenous immune globulin. Lupus 2, 371–375.

    Article  PubMed  CAS  Google Scholar 

  79. Kra-Oz, Z., Lorber, M., Shoenfeld, Y., and Scharff, Y. (1993) Inhibitor(s) of natural anti-cardiolipin autoantibodies. Clin. Exp. Immunol. 93, 265–268.

    Article  PubMed  CAS  Google Scholar 

  80. Lorber, M., Kra-Oz, Z., Guilbrud, B., and Shoenfeld, Y. (1995) Natural (antiphospholipid-PDH,-DNA) autoantibodies and their physiologic serum inhibitors. (Review). Isr. J. Med. Sci. 31, 31–35.

    PubMed  CAS  Google Scholar 

  81. Bustos, A., Boimorto, R., Subiza, J. L., Pereira, L. F., Marco, M., Figueredo, M. A., et al. (1994) Inhibition of histone/anti-histone reactivity by histone-binding serum components; differential effect on anti-H1 versus anti-H2B antibodies. Clin. Exp. Immunol. 95, 408–414.

    Article  PubMed  CAS  Google Scholar 

  82. Shoelson, S. E., Marshall, S., Horikoshi, H., Kolterman, O. G., Rubenstein, A. H., and Okefsky, J. M. (1985) Antiinsulin receptor antibodies in an insulin-dependent diabetic may rise as autoantiidiotypes. J. Clin. Endocrinol. Metab. 63, 56–60.

    Article  Google Scholar 

  83. Dwyer, D. S., Bradley, R. J., Urquhart, C. K., and Kearney, J. F. (1983) Naturally occurring anti-idiotypic antibodies in myasthenia gravis patients. Nature 301, 611–614.

    Article  PubMed  CAS  Google Scholar 

  84. Sikorska, H. M. (1986) Anti-thyroglobulin anti-idiotypic antibodies in sera of patients with Hashimoto’s thyroiditis and Graves’ disease. J. Immunol. 137, 3786–3795.

    PubMed  CAS  Google Scholar 

  85. Xiu, L. L. (1994). Studies on autoimmune mechanisms of thyroglobulin autoanti-body in autoimmune thyroid disease. Hiroshima J. Med. Sci. 43, 1–11.

    PubMed  CAS  Google Scholar 

  86. Zhang, L., Jayne, D. R., and Oliveira, D. B. (1993) Anti-idiotype antibodies to anti-mitochondrial antibodies in the sera of patients with primary biliary cirrhosis. J. Autoimmun. 6, 93–105.

    Article  PubMed  CAS  Google Scholar 

  87. Stefanescu, M., Matache, C., Onu, A., Cristescu, C., Cremer, L., and Szegli, G. (1993) Identification of anti-idiotypic antibodies to anti-phosphotyrosine antibodies in human sera. Autoimmunity 15, 181–186.

    Article  PubMed  CAS  Google Scholar 

  88. Mackworth-Young, C. G., and Schwartz, R. S. (1988) An idiotope-specific autoantibody in SLE. Clin. Exp. Immunol. 71, 56–61.

    PubMed  CAS  Google Scholar 

  89. Moore, T. L., Dorner, R. W., Alexander, R. L., and Osborn, T. G. (1988) Enzyme linked (ELISA) immunoabsorbent assay for the detection of hidden 19S IgM rheumatoid factors in juvenile rheumatoid arthritis. J. Rheumatol. 15, 87–90.

    PubMed  CAS  Google Scholar 

  90. Targoff, I. N. and Reichlin, M. (1985) Unmasking of cytoplasmic fluorescence of anti-Jo-1 by purification of antibody. Arthritis Rheum. 28, S74.

    Google Scholar 

  91. Zhang, W. and Reichlin, M. (1996) Some autoantibodies to Ro/SSA and La/SSB are antiidiotypes to antidouble-stranded DNA. Arthritis Rheum. 39, 522–531.

    Article  PubMed  CAS  Google Scholar 

  92. Zhang, W. and Reichlin, M. (1996) Some autoantibodies to U1RNP are idiotypes to anti-dsDNA. (Abstract) Arthritis Rheum. 39, S1

    Google Scholar 

  93. Zhang, W., Reichlin, M., Wasson, C., et al. (1996) Broad cross-reaction of an anti-id reagent with anti-dsDNA from several patients with systemic lupus erythemato-sus (SLE). (Abstract) Arthritis Rheum. 39, S1

    Google Scholar 

  94. Zhou, S-R. and Whitaker, J. N. (1993) Specific modulation of T cells and murine experimental allergic encephalomyelitis by monoclonal anti-idiotypic antibodies. J. Immunol. 150, 1629–1642.

    PubMed  CAS  Google Scholar 

  95. Cohen, P. L. (1982) Anti-idiotypic antibodies to the Coombs antibody in NZB F1 mice. J. Exp. Med. 156, 173–180.

    Article  PubMed  CAS  Google Scholar 

  96. Hahn, B. H. and Ebling, F. M. (1983) Suppression of NZB/NZW murine nephritis by administration of a syngeneic monoclonal antibody to DNA. Possible role of anti-idiotypic antibodies. J. Clin. Invest. 71, 1728–1736.

    Article  PubMed  CAS  Google Scholar 

  97. Silvestris, F., Bankhurst, A. D., Searles, R. A., et al. (1983) Anti-F(ab’)2 antibodies and possible auto-idiotypic control mechanism in systemic lupus erythemato-sus. (Abstract) Clin. Res. 31, 785A.

    Google Scholar 

  98. Williams, R. C., Jr., Malone, C. C., and Silvestris, F. (1995) CDR molecular localization of possible anti-idiotypic anti-DNA antibodies in normal subjects, patients with SLE, and SLE first-degree relatives. J. Lab. Clin. Med. 126, 44–56.

    PubMed  Google Scholar 

  99. Nasu, H., Chia, D.S., Taniguchi, O., and Barnett, E. V. (1982) Characterization of anti-F(ab’)2 antibodies in SLE patients. Evidence for cross-reacting auto-anti-idiotypic antibodies. Clin. Immunol. Immunopath. 25, 80–90.

    Article  CAS  Google Scholar 

  100. Abdou, N. I., Wall, H., Lindsley, H. B., Halsey, J. F., and Suzuki, T. (1981) Network theory in autoimmunity: in vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. J. Clin. Invest. 67, 1297–1304.

    Article  PubMed  CAS  Google Scholar 

  101. Zouali, M. and Eyquem, A. (1983) Idiotypic/antiidiotypic interactions in systemic lupus erythematosus: demonstration of oscillary levels of anti-DNA autoantibodies and reciprocal antiidiotypic activity in a single patient. Ann. Immunol. 134c, 377–391.

    CAS  Google Scholar 

  102. Silvestris, F., D’Amore, O., Cafforio, P., Savino, L., and Dammacco, F. (1996) Intravenous immune globulin therapy of lupus nephritis: use of pathogenic anti-DNA-reactive IgG. Clin. Exp. Immunol. 1, 91–97.

    Google Scholar 

  103. Jayne, D. R., Esnault, V. L., and Lockwood, C. M. (1993) Anti-idiotype antibodies to anti-myeloperoxidase autoantibodies in patients with systemic vasculitis. J. Autoimmun. 6, 221–226.

    Article  PubMed  CAS  Google Scholar 

  104. Jayne, D. R., Esnault, V. L., and Lockwood, C. M. (1993) ANCA anti-idiotype antibodies and the treatment of systemic vasculitis with intravenous immunoglo-bulin. (Review). J. Autoimmun. 6, 207–219.

    Article  PubMed  CAS  Google Scholar 

  105. Gilles, J. G., Desqueper, B., Lenk, H., Vermylen, J., and Saint-Remy, J. M. (1996) Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A. J. Clin. Invest. 97, 1382–1388.

    Article  PubMed  CAS  Google Scholar 

  106. Balazs, C. and Molnar, I. (1995) In vitro suppression of anti-TSH receptor antibody by autologous anti-idiotypic antibody in patients with Graves’ disease. Acta Microbiologica et Immunologica Hungarica 42, 163–169.

    PubMed  CAS  Google Scholar 

  107. Williams, R. C., Jr., Malone, C. C., Huffman, G. R., Silvestris, F., Croker, B. P., Ayoub, E. M., et al. (1995) Active systemic lupus erythematosus is associated with depletion of the natural generic anti-idiotype (anti-F(ab’)2) system. J. Rheumatol. 22, 1075–1085.

    PubMed  Google Scholar 

  108. Teitelbaum, D., Rauch, J., Stollar, B. D., and Schwartz, R. S. (1984) In vivo effects of antibodies against a high frequency idiotype of anti-DNA antibodies in MRL mice. J. Immunol. 132, 1282–1285.

    PubMed  CAS  Google Scholar 

  109. Carteron, N. L., Schimenti, C. L., and Wofsy, D. (1989) Treatment of murine lupus with F(ab’)2 fragments of monoclonal antibodies. Eur. J. Immunol. 17, 541.

    Google Scholar 

  110. Shoenfeld, Y. (1994) The significance of experimental models of systemic lupus erythematosus and antiphospholipid syndrome induced by idiotypic manipulation. Isr. J. Med. Sci. 30, 10–18.

    PubMed  CAS  Google Scholar 

  111. Puccetti, A., Migliorini, P., Sabbaga, J., and Madaio, M. P. (1990) Human and murine anti-DNA antibodies induce the production of anti-idiotypic antibodies with autoantigen-binding properties (epibodies) through immune-network interactions. J. Immunol. 145, 4229–4237.

    PubMed  CAS  Google Scholar 

  112. Bona, C. A., Finley, S., Waters, S., and Kunkel, H. G. (1982) Anti-immunoglobu-lin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterolo-gous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies). J. Exp. Med. 156, 986–999.

    Article  PubMed  CAS  Google Scholar 

  113. Wassermann, N. H., Penn, A. S., Freimuth, P. I., Treptow, N., Wentzel, S., Cleveland, W. L., et al. (1982) Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis. Proc. Natl. Acad. Sci. USA 79, 4810–4814.

    Article  PubMed  CAS  Google Scholar 

  114. Bako, G., Islam, M. N., and Farid, N. R. (1985) Photoaffinity labelling of the porcine thyrotropin receptor—effect of Graves’ immunoglobulin G and anti-TSH anti-idiotypic antibodies. Clin. Invest. Med. — Medecine Clinique et Experimentale 8, 152–159.

    CAS  Google Scholar 

  115. Erlanger, B. F., Cleveland, W. L., Wasserman, N. H., Ku, N. H., Hill, B. L., Sarangarajan, R., et al. (1986) The auto-anti-idiotypic route to anti-receptor antibodies, in Idiotypes (Erlanger, B. F., Cleveland, W. L., Wasserman, N. H., Reichlin, M., Capra, J. D., et al., eds.), Academic, Orlando, FL, pp. 157–178.

    Chapter  Google Scholar 

  116. Paul, S., Volle, D. J., Beach, C. M., Johnson, D. R., Powell, M. J., and Massey, M. J. (1989) Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science 224, 1158–1162.

    Article  Google Scholar 

  117. Shuster, A. M., Gololobov, G. V., Kvashuk, O. A., Bogomolova, A. E., Smirnov, I.V., and Gabibov, A.G. (1992) DNA hydrolyzing autoantibodies. Science 256, 665–667.

    Article  PubMed  CAS  Google Scholar 

  118. Izadyar, L., Friboulet, A., Remy, M. H., Roseto, A., and Thomas, D. (1993) Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: Production of a catalytic antibody with a cholinesterase activity. Proc. Natl. Acad. Sci. USA 90, 8876–8880.

    Article  PubMed  CAS  Google Scholar 

  119. Mayfurth, R. D. and Quintans, J. (1990) Designer and catalytic antibodies. N. Engl. J. Med. 323, 173–178.

    Article  Google Scholar 

Download references

Authors
  1. Haraldine A. Stafford
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Morris Reichlin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, TX, USA

    Sudhir Paul

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Stafford, H.A., Reichlin, M. (1999). Dysregulation of the Idiotype Network in Autoimmune Diseases. In: Paul, S. (eds) Autoimmune Reactions. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1610-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1610-0_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7215-1

  • Online ISBN: 978-1-4612-1610-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation