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The Role of Exogenous Stimulation in Pathogenesis of Autoimmune Diseases

  • Chapter
Autoimmune Reactions

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

A properly operating immune system enables the body to maintain a healthy status quo by distinguishing between the antigens associated with the organism itself, which are allowed to persist, and the antigens borne by foreign molecules, which are disposed. Burnet (1). proposed that the ability of immune system to distinguish “self and nonself ‘antigens results from the elimination of self-reactive lymphocytes during ontogenic development. This concept is supported by recent data originating from studies carried out in transgenic mice demonstrating that self-reactive T- and B- lymphocytes are deleted from the repertoire. In the thymus, a process known as negative selection appears to result in deletion of T-cells bearing receptors with high affinity for self-antigens (2,3). In the fetal liver and bone marrow, a similar process deletes the emerging B-cells bearing an Ig receptor specific for cellular antigens (4).

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  1. Constantin Bona
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  2. Chihiro Murai
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  3. Takeshi Sasaki
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  1. Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, TX, USA

    Sudhir Paul

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Bona, C., Murai, C., Sasaki, T. (1999). The Role of Exogenous Stimulation in Pathogenesis of Autoimmune Diseases. In: Paul, S. (eds) Autoimmune Reactions. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1610-0_10

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  • DOI: https://doi.org/10.1007/978-1-4612-1610-0_10

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