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Abstract

Schizophrenia is a severe mental illness that affects approx 1% of men and women worldwide. It is a disease with profound public health and economic implications, let alone the devastation it brings to afflicted individuals and their families. The first symptoms usually occur in late adolescence or early adulthood and last throughout life. While the manifestations may be diverse, the syndrome is typically characterized by disorganized thought processes, hallucinations and delusions, emotional and social withdrawal, and deterioration in independent functioning. Cognitive impairment has been increasingly well recognized as an important component of the disease.

Keywords

Alzheimer Disease Schizophrenic Patient Entorhinal Cortex Bioi Psychiatry Minor Physical Anomaly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hecker E. Die hebephrenie. Arch Pathol Anat Physiol Klin Med 1871, 52: 394–401.Google Scholar
  2. 2.
    Alzheimer A. Beitrage zur pathologischen Anatomie der Dementia Praecox. Allg Z Psychiatr Psychischgericht Med 1913, 70: 810–840.Google Scholar
  3. 3.
    Proceedings of the First International Congress of Neuropathology, vol 1. (Rosenberg and Sellier), Turin, Italy, 1952.Google Scholar
  4. 4.
    Gottesman II. Schizophrenia Genesis. W.H. Freeman, New York, 1991.Google Scholar
  5. 5.
    McGuffin P, Anderson P, Owen M, et al. The strength of the genetic effect: is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 1994, 164: 593–599.PubMedCrossRefGoogle Scholar
  6. 6.
    Mednick SA, Machon RA, Huttunen MO, Bonnett D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988, 45: 189–92.PubMedCrossRefGoogle Scholar
  7. 7.
    Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM. Schizophrenia after prenatal famine. Arch Gen Psychiatry 1996, 53: 25–31.PubMedCrossRefGoogle Scholar
  8. 8.
    Hollister JM, Laing P, Mednick SA. Rhesus incompatibility as a risk factor for schizophrenia in male adults. Arch Gen Psychiatry 1996, 53: 19–24.PubMedCrossRefGoogle Scholar
  9. 9.
    Cannon TD, Megginson-Hollister J, Bearden CE, Hadley T. A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. NEJM 1996, submitted.Google Scholar
  10. 10.
    McNeil TF, Cantor-Graae E, Nordstrom LG, Rosenlund T. Head circumference in “preschizophrenics” and control neonates. Br J Psychiatry 1993, 162: 517–523.PubMedCrossRefGoogle Scholar
  11. 11.
    O’Callaghan E, Larkin C, Kinsella A, Waddington JL. Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia. Am J Psychiatry 1991, 148: 479–483.PubMedGoogle Scholar
  12. 12.
    Walker E. Developmentally moderated expressions of the neuropathology underlying schizophrenia. Schizophr Bull 1994, 20: 453–480.PubMedCrossRefGoogle Scholar
  13. 13.
    Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult onset schizophrenia in the British 1946 birth cohort. Lancet 1994, 344: 1398–402.PubMedCrossRefGoogle Scholar
  14. 14.
    Liddle PF. Brain imaging, in Schizophrenia, (Hirsch SR, Weinberger DR, eds.), Blackwell, London, England, 1995, pp. 295–323.Google Scholar
  15. 15.
    Ciompi L. Catamnestic long-term study on the course of life and aging of schziophrenics. Schizophr Bull 1980, 6: 606–618.PubMedCrossRefGoogle Scholar
  16. 16.
    Winokur G, Pfohl B, Tsuang M. A 40-year follow-up of hebephrenic-catatonic schizophrenia, in Schizophrenia and Aging, (Miller N, Cohen G, eds.), Guilford, New York, 1987, pp. 52–60.Google Scholar
  17. 17.
    Lindstrom LH. Clinical and biological markers for outcome in schizophrenia. Neuropsychopharmacology 1996, 14: 23S-26S.Google Scholar
  18. 18.
    Davidson M, Harvey PD, Powchik P, Parella M, White L, Knobler HY, Losonczy MF, Keefe RSE, Katz S, Frecska E. Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry 1995, 152: 197–207.PubMedGoogle Scholar
  19. 19.
    Arnold SE, Gur RE, Shapiro RM, Fisher KR, Moberg PJ, Gibney MR, Gur RC, Blackwell P, Trojanowski JQ. Prospective clinicopathological studies of schizophrenia: Accrual and assessment. Am J Psychiatry 1995, 152: 731–737.PubMedGoogle Scholar
  20. 20.
    Moberg PJ, Mahr R, Gibney M, Arnold SE, Shapiro R, Kumar A, Gottlieb G, Gur RE. Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer’s disease. JINS 1995, 1: 132.Google Scholar
  21. 21.
    Arnold SE, Franz BR, Trojanowski JQ. Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions. Neurobiol Aging 1994, 15: 299–303.PubMedCrossRefGoogle Scholar
  22. 22.
    Arnold SE, Trojanowski JQ, Gur RE, Han L-Y, Franz BR, Ruscheinsky DD. Investigations of neurodegneration and neural injury in the brains of elderly patients with schizophrenia. Arch Gen Psychiatry 1996, submitted.Google Scholar
  23. 23.
    Moberg PJ, Doty RL, Mahr RN, Arnold SE, Turetsky BI, McKeown DA, Gur RC, Gur RE. Olfactory deficits in young and elderly patients with schizophrenia. Am J Psychiatry 1996, submitted.Google Scholar
  24. 24.
    Vita A, Sacchetti E, Valvassori G, Cazullo CL. Brain morphology in schizophrenia: a 2-to 5-year CT follow-up study. Acta Psychiatr Scand 1988, 78: 618–621.PubMedCrossRefGoogle Scholar
  25. 25.
    DeLisi LE, Tew W, Xie SH, Hoff AL, Sakuma M, Kushner M, Lee G, Shedlack K, Smith AM, Grimson R. A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients-preliminary findings. Biol Psychiatry 1995, 38: 349–360.PubMedCrossRefGoogle Scholar
  26. 26.
    Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Gur RC. A follow-up study of neuroanatomical, clinical, and neurobehavioral measures in schizophrenia. Arch Gen Psychiatry 1996, submitted.Google Scholar
  27. 27.
    Stevens JR. Neuropathology of schizophrenia. Arch Gen Psychiatry 1982, 39: 1131–1139.PubMedCrossRefGoogle Scholar
  28. 28.
    Bruton CJ, Crow TJ, Frith CD, Johnstone EC, Owens DGC, Roberts GW. Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychol Med 1990, 20: 285–304.PubMedCrossRefGoogle Scholar
  29. 29.
    Golier JA, Davidson M, Haroutunian V, Powchik P, Purohit D, Perl D, Davis KL. Neuro-pathological study of 101 elderly schizophrenics: Preliminary findings. Schizophr Res 1995, 15: 120.Google Scholar
  30. 30.
    Bogerts B. Recent advances in the neuropathology of schizophrenia. Schizophr Bull 1993, 19: 431–445.PubMedCrossRefGoogle Scholar
  31. 31.
    Arnold SE, Trojanowski JQ. Recent advances in defining the neuropathology of schizophrenia. Acta Neuropathol 1996, in press.Google Scholar
  32. 32.
    West MJ. New stereological methods for counting neurons. Neurobiol Aging 1993, 14: 287–293.PubMedCrossRefGoogle Scholar
  33. 33.
    Holinger DP, Rosen GD, Galaburda AM. Decreased neuronal density in supragranular layer of area Tpt of the superior temproal gyrus of schizophrenics. Soc Neurosci Abstr 1995, 21: 238.Google Scholar
  34. 34.
    Falkai P, Bogerts B. Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatry Neurol Sci 1986, 236: 154–161.PubMedCrossRefGoogle Scholar
  35. 35.
    Jeste DV, Lohr JB. Hippocampal pathologic findings in schizophrenia: a morphometric study. Arch Gen Psychiatry 1989, 46: 1019–1024.PubMedCrossRefGoogle Scholar
  36. 36.
    Falkai P, Bogerts B, Rozumek M. Limbic pathology in schizophrenia: the entorhinal region—a morphometric study. Biol Psychiatry 1988, 24: 515–521.PubMedCrossRefGoogle Scholar
  37. 37.
    Arnold SE, Franz BR, Gur RC, Gur RE, Shapiro RM, Moberg PJ, Trojanowski JQ. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry 1995, 152: 738–748.PubMedGoogle Scholar
  38. 38.
    Kovelman JA, Scheibel AB. A neurohistological correlate of schizophrenia. Biol Psychiatry 1984, 19: 1601–1621.PubMedGoogle Scholar
  39. 39.
    Benes FM, Sorensen I, Bird ED. Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr Bull 1991, 17: 597–608.PubMedCrossRefGoogle Scholar
  40. 40.
    Heckers S, Heinsen H, Geiger B, Beckmann H. Hippocampal neuron number in schizophrenia. A stereological study. Arch Gen Psychiatry 1991, 48: 1002–1008.PubMedCrossRefGoogle Scholar
  41. 41.
    Benes FM, Davidson J, Bird ED. Quantitative cytoarchtectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 1986, 43: 31–35.PubMedCrossRefGoogle Scholar
  42. 42.
    Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991, 48: 996–1001.PubMedCrossRefGoogle Scholar
  43. 43.
    Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex: A morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry 1995, 52: 805–818.PubMedCrossRefGoogle Scholar
  44. 44.
    Pakkenberg B, Gundersen JG. Total number of neurons and glial cells in human brain nuclei estimated bythe disector and the fractionator. J Microscopy 1988, 150: 1–20.CrossRefGoogle Scholar
  45. 45.
    Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenia. Arch Gen Psychiatry 1990, 47: 1023–1028.PubMedCrossRefGoogle Scholar
  46. 46.
    Bogerts B, Hantsch J, Herzer M. A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics. Biol Psychiatry 1983, 18: 951–969.PubMedGoogle Scholar
  47. 47.
    Reyes MG, Gordon A. Cerebellar vermis in schizophrenia. Lancet 1981, 2: 700–701.PubMedCrossRefGoogle Scholar
  48. 48.
    Lohr JB, Jeste DV. Locus ceruleus morphometry in aging and schizophrenia. Acta Psychiatr Scand 1988, 77: 689–697.PubMedCrossRefGoogle Scholar
  49. 49.
    Karson CN, Garcia-Rill E, Biedermann J, Mrak RE, Husain MM, Skinner RD. The brain stem reticular formation in schizophrenia. Psychiatry Res 1991, 40: 31–48.PubMedCrossRefGoogle Scholar
  50. 50.
    Garcia-Rill E, Biedermann JA, Chambers T, Skinner RD, Mrak RE, Husain M, Karson CN. Mesopontine neurons in schizophrenia. Neuroscience 1995, 66: 321–335.PubMedCrossRefGoogle Scholar
  51. 51.
    el-Mallakh RS, Kirch DG, Shelton R, Fan KJ, Pezeshkpour G, Kanhouwa S, Wyatt RJ, Kleinman JE. The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia. J Neuropsychiatry Clin Neurosci 1991, 3: 383–386.PubMedGoogle Scholar
  52. 52.
    Purohit DP, Davidson M, Perl DP, Powchik P, Haroutunian VH, Bierer LM, McCrystal J, Losonsczy M, Davis KL. Severe cognitive impairment in elderly schizophrenic patients: A clinicopathological study. Biol Psychiatry 1993, 33: 255–260.PubMedCrossRefGoogle Scholar
  53. 53.
    Powchik P, Davidson M, Nemeroff CB, Haroutunian V, Purohit DP, Losonczy M, Bissette G, Perl D, Ghanbari H, Miller B, Davis K. Alzheimer’s-disease-related protein in geriatric schizophrenic patients with cognitive impairment. Am J Psychiatry 1993, 150: 1726–1727.PubMedGoogle Scholar
  54. 54.
    Taller AM, Asher DM, Pomeroy KL, Eldadah BA, Godec MS, Falkai PG, Bogert B, Kleinman JE, Stevens JR, Torrey EF. Search for viral nucleic acid sequences in brain tissues of patients with schizophrenia using nested polymerase chain reaction. Arch Gen Psychiatry 1996, 53: 32–40.PubMedCrossRefGoogle Scholar
  55. 55.
    Roberts GW, Colter N, Lofthouse R, Johnstone EC, Crow TJ. Is there gliosis in schizophrenia? Investigation of the temporal lobe. Biol Psychiatry 1987, 22: 1459–1468.PubMedCrossRefGoogle Scholar
  56. 56.
    Stevens CD, Altshuler LL, Bogerts B, Falkai P. Quantitative study of gliosis in schizophrenia and Huntington’s chorea. Biol Psychiatry 1988, 24: 697–700.PubMedCrossRefGoogle Scholar
  57. 57.
    Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, Frith CD, Johnstone EC, Owens DG, Roberts GW. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry 1989, 46: 1145–1150.PubMedCrossRefGoogle Scholar
  58. 58.
    Arnold SE, Franz BR, Trojanowski JQ, Moberg PJ, Gur RE. Glial fibrillary acidic protein immunoreactive astrocytosis in elderly patients with schizophrenia and dementia. Acta Neuropathol 1996, 91: 269–277.PubMedCrossRefGoogle Scholar
  59. 59.
    Norton WT, Aquino DA, Hozumi I, Chiu F-C, Brosnan CF. Quantitative aspects of reactive gliosis: A review. Neurochem Res 1992, 17: 877–885.PubMedCrossRefGoogle Scholar
  60. 60.
    Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB. Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 1991, 48: 413–417.PubMedCrossRefGoogle Scholar
  61. 61.
    Altshuler LL, Conrad A, Kovelman JA, Scheibel A. Hippocampal pyramidal cell orientation in schizophrenia. Arch Gen Psychiatry 1987, 44: 1094–1098.PubMedCrossRefGoogle Scholar
  62. 62.
    Christison GW, Casanova MF, Weinberger DR, Rawlings R, Kleinman JE. A quantitative investigation of hippocampal pyramidal cell size, shape, and variability of orientation in schizophrenia. Arch Gen Psychiatry 1989, 46: 1027–1032.PubMedCrossRefGoogle Scholar
  63. 63.
    Jakob H, Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 1986, 65: 303–326.PubMedCrossRefGoogle Scholar
  64. 64.
    Arnold SE, Hyman BT, Hoesen GWV, Damasio AR. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 1991, 48: 625–632.PubMedCrossRefGoogle Scholar
  65. 65.
    Krimer LS, Herman MM, Saunders RC, Boyd JC, Kleinman JE, Hyde TM, Weinberger DR. Qualitative and quantitative analysis of the entorhinal cortex cytoarchitectural organization in schizophrenia. Soc Neurosci Abstr 1995, 21: 239.Google Scholar
  66. 66.
    Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE, Jones EG. Maldistribuiton of interstitial neurons in prefrontal white matter of the the brains of schizophrenic patients. Arch Gen Psychiatry 1996, 53: 425–436.PubMedCrossRefGoogle Scholar
  67. 67.
    Lipska BK, Jaskiw GE, Weinberger DR. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology 1993, 9: 67–75.PubMedGoogle Scholar
  68. 68.
    Lipska BK, Weinberger DR. Behavioral effects of subchronic treatment with haloperidol or clozapine in rats with neonatal excitotoxic hippocampal damage. Neuropsychopharmacology 1994, 10: 199–205.PubMedGoogle Scholar
  69. 69.
    Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology 1995, 122: 35–43.PubMedCrossRefGoogle Scholar
  70. 70.
    Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995, 52: 998–1007.PubMedCrossRefGoogle Scholar
  71. 71.
    Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B. Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 1980, 30: 379–382.CrossRefGoogle Scholar
  72. 72.
    Deakin JFW, Slater P, Simpson MDC, Gilchrist AC, Skan WJ, Royston MC, Reynolds GP, Cross AJ. Frontal cortical and left temporal glutamtergic dysfunction in schizophrenia. J Neurochem 1989, 52: 1781–1786.PubMedCrossRefGoogle Scholar
  73. 73.
    Kerwin R, Patel S, Meldrum B. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 1990, 39: 25–32.PubMedCrossRefGoogle Scholar
  74. 74.
    Simpson MDC, Slater P, Royston MC, Deakin JFW. Regionally selective deficits in uptake sites for glutamate and gamma-amino butyric acid in the basal ganglia in schizophrenia. Psychiatry Res 1992, 42: 273–282PubMedCrossRefGoogle Scholar
  75. 75.
    Eastwood SL, McDonald B, Burnet PW, Beckwith JP, Kerwin RW, Harrison PJ. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Brain Res Molec Brain Res 1995, 29: 211–223.CrossRefGoogle Scholar
  76. 76.
    Simpson MDC, Royston MC, Slater P, Deakin JFW. Phencyclidine and sigma receptor abnormalities in schizophrenic post-mortem brain. Schizophr Res 1990, 3: 32.CrossRefGoogle Scholar
  77. 77.
    Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry 1995, 52: 829–836.PubMedCrossRefGoogle Scholar
  78. 78.
    Benes FM, Sorensen I, Vincent SL, Bird ED, Sathi M. Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain. Cereb Cortex 1992, 2: 503–512.PubMedCrossRefGoogle Scholar
  79. 79.
    Akbarian S, Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE, Jones EG. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry 1995, 52: 258–266.PubMedCrossRefGoogle Scholar
  80. 80.
    Bardgett ME, Jackson JL, Taylor GT, Csernansky JG. Kainic acid decreases hippocampal neuron number and increasesdopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia. Behav Brain Res 1995, 70: 153–164.PubMedCrossRefGoogle Scholar
  81. 81.
    Mattson MP. Cellular signaling mechanisms common to the development and degeneration of neuroarchitecture. A review. Mech Ageing Dev 1989, 50: 103–157.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Steven E. Arnold

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