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Mechanisms of Cell Injury in Prion Diseases

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Cell Death and Diseases of the Nervous System

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Abstract

Transmissible spongiform encephalopathies (TSE) are associated with the progressive destruction of neural systems involved in cognition and movement. Gene targeting and transgenic strategies have provided strong evidence for the central role of the prion protein in the transmission and pathogenesis of TSEs, now termed prion diseases, and have begun to be used to examine the mechanisms by which the formation of conformationally altered prion proteins cause cell dysfunction and death.

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  1. David R. Borchelt
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  1. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Vassilis E. Koliatsos MD

  2. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Rajiv R. Ratan MD, PhD

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Borchelt, D.R. (1999). Mechanisms of Cell Injury in Prion Diseases. In: Koliatsos, V.E., Ratan, R.R. (eds) Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1602-5_15

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  • DOI: https://doi.org/10.1007/978-1-4612-1602-5_15

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