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Viral Encephalitis

  • Chapter
Cell Death and Diseases of the Nervous System

Abstract

Encephalitis, strictly defined as inflammation of the brain, most commonly results from acute viral infection of the central nervous system (CNS). While many thousands of cases of viral encephalitis occur worldwide each year, infections caused by the arthropod-borne viruses (arboviruses) and herpes simplex virus (HSV) are the most life-threatening. The arboviruses that cause encephalitis in humans include members of the flavivirus family, the bunyavirus family, and the alphavirus genus of the togavirus family. The prototype alphavirus, Sindbis virus, causes an epidemic arthritis in humans and an acute encephalitis in mice. Since murine Sindbis virus infection exhibits many features that are similar to the human alphavirus-induced encephalitides, it serves as a useful animal model for studying these illnesses.

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Authors
  1. J. Marie Hardwick
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  2. David N. Irani
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  3. Diane E. Griffin
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Editors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Vassilis E. Koliatsos MD

  2. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Rajiv R. Ratan MD, PhD

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Hardwick, J.M., Irani, D.N., Griffin, D.E. (1999). Viral Encephalitis. In: Koliatsos, V.E., Ratan, R.R. (eds) Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1602-5_14

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