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Immunoprotection of Islets of Langerhans by Microencapsulation in Barium Alginate Beads

  • Tobias D. C. Zekorn
  • Reinhard G. Bretzel

Abstract

Today the fate of diabetic patients is determined by the development of secondary complications such as blindness, neuropathy, and end-stage renal failure. The DCCT study1 confirmed a positive correlation of intensified insulin treatment with a reduced development of these complications. Further improvement of metabolic control could be achieved by transplantation of insulin-producing islet cells. However, a principal obstacle for this method is side effects due to chronic application of the required immunosuppression, i.e., cyclosporine A-induced hypertension and islet toxicity,2 that could be more harmful than the disease itself. Therefore, successful transplantation of islets entrapped in immunoprotective membranes (bioartificial endocrine pancreas = BAEP) would circumvent these problems and also allow transplantation of islet tissue from other species (i.e., pig) or of engineered cells. Moreover, after successful application of this principle to diabetes, it can be applied to other diseases such as phenylketonuria, pain, adrenal and neuroendocrine deficiency syndromes, hematologic diseases, etc.

Keywords

Alginate Bead Porcine Islet Polyamino Acid Encapsulate Islet Encapsulation Procedure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Tobias D. C. Zekorn
  • Reinhard G. Bretzel

There are no affiliations available

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