Abstract
Our group at the Beth Israel Deaconess Medical Center (formerly Deaconess Hospital) and a team at Circe Biomedical, Inc. (formerly Grace Biomedcal, WR Grace and Co.-Conn) have studied the use of a vascularized bioartificial pancreas (VB AP) for treatment of diabetes for the past 6 years.1–4 We were the first to demonstrate the long-term use of a bioartificial pancreas in large animals, and our data represented the longest survival of discordant xenogeneic islets. In this report we will briefly describe the VBAP device, a large animal diabetes model, experimental results with the use of allogeneic and xenogeneic islets in the device, and plans to initiate a clinical trial of the VBAP containing porcine islets for treatment of patients with earlystage IDDM.
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Maki, T., Monaco, A.P., Mullon, C.J., Solomon, B.A. (1999). Vascular Devices. In: Kühtreiber, W.M., Lanza, R.P., Chick, W.L. (eds) Cell Encapsulation Technology and Therapeutics. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1586-8_16
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DOI: https://doi.org/10.1007/978-1-4612-1586-8_16
Publisher Name: Birkhäuser, Boston, MA
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