Possible Role of the Transcription Factor Oct-3/4 in Control of Human Chorionic Gonadotropin Expression

  • Limin Liu
  • Douglas Leaman
  • R. Michael Roberts
Part of the Proceedings in the Serono Symposia USA Series book series (SERONOSYMP)

Abstract

During a study on the regulation of interferon-i genes in choriocarcinoma cells, an hCGa-CAT construct was included as an internal control to check transfection efficiencies. Although Oct-3/4 coexpression had little effect on expression from an IFN-ti promoter that carried several potential Oct binding sequences, the hCGa-CAT construct was strongly silenced. This serendipitous discovery led to the data reported in this chapter and two earlier papers (1,2).

Keywords

Clay Adenosine Polypeptide Interferon Thymidine 

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Limin Liu
  • Douglas Leaman
  • R. Michael Roberts

There are no affiliations available

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