Skip to main content
SpringerLink
Log in
Book cover

Embryo Implantation pp 261–270Cite as

Possible Role of the Transcription Factor Oct-3/4 in Control of Human Chorionic Gonadotropin Expression

  • Chapter

  • 122 Accesses

Part of the book series: Proceedings in the Serono Symposia USA Series ((SERONOSYMP))

Abstract

During a study on the regulation of interferon-i genes in choriocarcinoma cells, an hCGa-CAT construct was included as an internal control to check transfection efficiencies. Although Oct-3/4 coexpression had little effect on expression from an IFN-ti promoter that carried several potential Oct binding sequences, the hCGa-CAT construct was strongly silenced. This serendipitous discovery led to the data reported in this chapter and two earlier papers (1,2).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Liu L, Roberts RM. Silencing of the gene for the ß-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. J Biol Chem 1996;271: 16683–9.

    Article  PubMed  CAS  Google Scholar 

  2. Liu L, Leaman D, Villalta M, Roberts RM. Silencing of the gene for the a-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. Mol Endocrinol 1997;11:1651–8.

    Article  PubMed  CAS  Google Scholar 

  3. Ogren L, Talamantes F. The placenta as an endocrine organ: polypeptides. In: Knobil E, Neill JD, eds. The Physiology of reproduction, 2d ed. New York: Raven, 1994:875–945.

    Google Scholar 

  4. Hearn JP, Webley GE, Gidley-Baird AA. Chorionic gonadotropin and embryo-maternal recognition during the periimplantation period in primates. J Reprod Fertil 1991;92:497–509.

    Article  PubMed  CAS  Google Scholar 

  5. Rao CV, Sanfilippo JS. New understanding in the biochemistry of implantation: potential direct roles of luteinizing hormone and human chorionic gonadotropin. Endocrinology 1997;7:107–11.

    Article  Google Scholar 

  6. Fazleabas AT, Donnelly KM, Fortman JD, Miller JB. Modulation of the baboon (Papio anubis) endometrium by chorionic gonadotropin (CG) during the period of uterine receptivity. Biol Reprod 1997;56(Suppl 1):176 (Abstr).

    Article  Google Scholar 

  7. Jameson JL, Hollenberg AN. Regulation of chorionic gonadotropin gene expression. Endocrinol Rev 1993;14:203–19.

    CAS  Google Scholar 

  8. Boothby M, Ruddon RW, Anderson C, McWilliams D, Boime I. A single gonadotropin a-subunit gene in normal tissue and tumor-derived cell lines. J Biol Chem 1981;256:5121–7.

    PubMed  CAS  Google Scholar 

  9. Bo M, Boime I. Identification of the transcriptionally active genes of the chorionic gonadotropin 13 gene cluster in vivo. J Biol Chem 1992;267:3179–84.

    PubMed  CAS  Google Scholar 

  10. Silver BJ, Bokar JA, Virgin JB, Vallen EA, Milsted A, Nilson JH. Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base pair element. Proc Nat Acad Sci USA 1987;84:2198–202.

    Article  PubMed  CAS  Google Scholar 

  11. Deutsch PJ, Jameson JL, Habener JF. Cyclic AMP responsiveness of human gonadotropin-a gene transcription is directed by a repeated 18-base pair enhancer. J Biol Chem 1987;262:12169–74.

    PubMed  CAS  Google Scholar 

  12. Delegeane AM, Fedand LH, Mellon PL. Tissue-specific enhancer of the human glycoprotein hormone a-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol 1987;7:3994–4002.

    PubMed  CAS  Google Scholar 

  13. Jameson JL, Powers AC, Gallagher GD, Habener JF. Enhancer, promoter element interactions dictate cyclic adenosine monophosphate mediated, cell-specific expression of the glycoprotein hormone a-gene. Mol Endocrinol 1989;3:763–72.

    Article  PubMed  CAS  Google Scholar 

  14. Andersen B, Kennedy GC, Nilson JH. A cis-acting element located between the cAMP response elements and CCAAT box augments cell-specific expression of the glycoprotein hormone alpha subunit gene. J Biol Chem 1990;265:21874–80.

    PubMed  CAS  Google Scholar 

  15. Kennedy GC, Andersen B, Nilson JH. The human a-subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor. J Biol Chem 1990;265: 6279–85.

    PubMed  CAS  Google Scholar 

  16. Steger DJ, Altschmied J, Boscher M, Mellon PL. Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin a-subunit genes. Mol Endocrinol 1991;5:243–55.

    Article  PubMed  CAS  Google Scholar 

  17. Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL. Regulation of the human chorionic gonadotropin alpha-and beta-subunit promoters by AP-2. J Biol Chem 1997;272:15405–12

    Article  PubMed  CAS  Google Scholar 

  18. Jameson JL, Lindell CM. Isolation and characterization of the human chorionic gonadotropin (3-subunit (CG13) gene cluster: regulation of a transcriptionally active CGI3 gene by cyclic AMP. Mol Cell Biol 1988;8:5100–7.

    PubMed  CAS  Google Scholar 

  19. Otani T, Otani F, Krych M, Chaplin DD, Boime I. Identification of a promoter region in the CGß gene cluster. J Biol Chem 1988;263:7322–9.

    PubMed  CAS  Google Scholar 

  20. Steger DJ, Boscher M, Hect JG, Mellon PL. Coordinate control of the a-and (3-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein. Mol Endocrinol 1993;7:1579–88.

    Article  PubMed  CAS  Google Scholar 

  21. Albanese C, Kay TWH, Toccoli NM, Jameson JL. Novel cyclic adenosine 3“, 5.monophosphate response element in the human chorionic gonadotropin 13-subunit gene. Mol Endocrinol 1991;5:693–702.

    Article  PubMed  CAS  Google Scholar 

  22. Pestell RG, Hollenberg AN, Albanese C, Jameson JL. C-Jun represses transcription of the human chorionic gonadotropin a and ß genes through distinct types of CREs. J Biol Chem 1994;269:31090–6.

    PubMed  CAS  Google Scholar 

  23. Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 1990;60:461–72.

    Article  PubMed  CAS  Google Scholar 

  24. Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rugby PW, et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 1990;345:686–92.

    Article  PubMed  CAS  Google Scholar 

  25. Scholer HR, Dressler GR, Balling R, Rohdewohld H, Gruss P. Oct-4: a germlinespecific transcription factor mapping to the mouse t-complex. EMBO J 1990;9: 2185–95.

    PubMed  CAS  Google Scholar 

  26. Verrijzer CP, Van der Vliet PC. POU domain transcription factors. Biochim Biophys Acta1993;1173:1–21.

    Google Scholar 

  27. Scholer HR, Ruppert S, Suzuki N, Chowhurdy K, Gruss P. A new type of POU domain in germ line-specific protein. Nature 1990;344:435–9.

    Article  PubMed  CAS  Google Scholar 

  28. Palmier SL, Peter W, Hess H, Scholer HR. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Devel Biol 1994;166:259–67.

    Article  Google Scholar 

  29. Okazawa H, Okamoto K, Ishino F, et al. The Oct-3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. EMBO J 1991;10:2997–3005.

    PubMed  CAS  Google Scholar 

  30. Pikarsky E, Sharir H, Ben-Shushan E, Bergman Y. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol Cell Biol 1994;14:1026–38.

    PubMed  CAS  Google Scholar 

  31. Meyer TE, Habener JF. Cyclic adenosine 3 ’,5 ’-monophate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev 1993;14:269–90.

    PubMed  CAS  Google Scholar 

  32. Gstaiger M, Knoepfel L, Georgiev O, Schaffner W. Hovens CM. A B-cell coactivator of octamer-binding transcription factors. Nature 1995;373:360–2.

    Article  PubMed  CAS  Google Scholar 

  33. Strubin M, Newell JW, Matthias P. OBF-1, a novel B-cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 1995;80:497–506.

    Article  PubMed  CAS  Google Scholar 

  34. Luo Y, Roeder RG. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol 1995;15: 4115–24.

    PubMed  CAS  Google Scholar 

  35. Verrijzer CP, Alkema MJ, Van Weperen WW, Van Leeuwen HC, Strating MJJ, van der Vilet PC. The DNA binding specificity of the bipartitie POU domain and its subdomains. EMBO J 1992;11:4993–5003.

    PubMed  CAS  Google Scholar 

  36. Pittman RH, Clay CM, Farmerie TA, Nilson JH. Functional analysis of the placenta-specific enhancer of the human glycoprotein hormone a-subunit gene. J Biol Chem 1994;269:19360–8.

    PubMed  CAS  Google Scholar 

  37. Bhat K, McBurney MW, Hamada H. Functional cloning of mouse chromosomal loci specifically active in embryonal carcinoma stem cells. Mol Cell Biol 1988;8: 3251–9.

    PubMed  CAS  Google Scholar 

  38. McKnight SL, Gavis ER, Kingsbury R, Axel R. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell 1981;25:385–98.

    Article  Google Scholar 

  39. Weis L, Reinberg D. Transcription by RNA polymerase II: initiator-directed formation of transcription-competent complexes. FASEB J 1992;6:3330–9.

    Google Scholar 

  40. Roy AL, Malik S, Meisterernst M, Roeder RG. An alternative pathway for transcription initiation involving Tfli-I. Nature 1993;365:355–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Limin Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Douglas Leaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Michael Roberts
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, University of Delaware, Newark, DE, 19716, USA

    Daniel D. Carson Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Liu, L., Leaman, D., Roberts, R.M. (1999). Possible Role of the Transcription Factor Oct-3/4 in Control of Human Chorionic Gonadotropin Expression. In: Carson, D.D. (eds) Embryo Implantation. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1548-6_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1548-6_22

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7188-8

  • Online ISBN: 978-1-4612-1548-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation