Estrogen Receptor Expression in the Pituitary Gland
Estradiol has been demonstrated to affect the production or release of all six major anterior pituitary hormones (1–5). Although some of the effects of estradiol on hormonal secretion are primarily hypothalamic in nature, other physiologically relevant actions appear to occur directly within the anterior pituitary gland itself (6–9). According to our current understanding of the signal transduction mechanics of estradiol, the presence of an estrogen receptor (ER) is necessary for such direct actions. This has been the primary rationale for performing experiments to determine which types of anterior pituitary cells express estrogen receptors. By defining which anterior pituitary cells are ER positive, we are identifying which populations of cells possess the necessary cellular machinery to make them at least capable of responding directly to estradiol.
KeywordsEstrogen Adenoma Dexamethasone Glucocorticoid Androgen
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