Estrogen Replacement Therapy and the Response to Human Growth Hormone
In young adults, growth hormone (GH) levels are higher in women than in men, and there is a positive correlation between serum estrogen and GH levels. Plasma IGF-I levels fall immediately after the onset of the menopause (1), and mean serum 24-h GH levels are lower than in premenopausal controls. Both estrogen and progesterone enhance the GH response to the somatostatin inhibitor pyridostigmine (2). Oral ethinyl estradiol increases serum GH levels but lowers IGF-I levels (3), suggesting a block in GH action at the liver.
KeywordsCholesterol Estrogen Progesterone Estradiol Neuroblastoma
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