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Estrogen Replacement Therapy and the Response to Human Growth Hormone

  • Gian Paolo Ceda
  • Giorgio Valenti
  • Andrew R. Hoffman
Chapter
Part of the Proceedings in the Serono Symposia USA Series book series (SERONOSYMP)

Abstract

In young adults, growth hormone (GH) levels are higher in women than in men, and there is a positive correlation between serum estrogen and GH levels. Plasma IGF-I levels fall immediately after the onset of the menopause (1), and mean serum 24-h GH levels are lower than in premenopausal controls. Both estrogen and progesterone enhance the GH response to the somatostatin inhibitor pyridostigmine (2). Oral ethinyl estradiol increases serum GH levels but lowers IGF-I levels (3), suggesting a block in GH action at the liver.

Keywords

Growth Hormone Growth Hormone Level Estrogen Replacement Therapy Oral Estrogen Growth Hormone Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Romagnoli E, Minisola S, Camevale V, Scarda A, Rosso R, Scarnecchia L, et al. Effect of estrogen deficiency on IGF-I plasma levels: relationship with bone mineral density in perimenopausal women. Calif Tissue Int 1993;53:1–6.CrossRefGoogle Scholar
  2. 2.
    O’Keane V, Dinan TG. Sex steroid priming effects on growth hormone response to pyridostigmine throughout the menstrual cycle. J Clin Endocrinol Metab 1992;5:11–4.CrossRefGoogle Scholar
  3. 3.
    Dawson-Hughes B, Stern D, Goldman J, Reichlin S. Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. J Clin Endocrinol Metab 1986;63:424–32.PubMedCrossRefGoogle Scholar
  4. 4.
    Lieberman SA, Mitchell AM, Hintz R, Marcus R, Hoffman AR. The insulin-like growth factor-I generation test: resistance to growth hormone during aging and estrogen replacement therapy. Horm Metab Res 1994;26:229–33.PubMedCrossRefGoogle Scholar
  5. 5.
    Mercuri N, Petraglia F, Genazzani AD, Amato F, Sgherzi MR, Maietta-Latessa A, et al. Hormonal treatments modulate pulsatile plasma growth hormone, gonadotro-phin and osteocalcin levels in postmenopausal women. Maturitas 1993; 17:51–62.PubMedCrossRefGoogle Scholar
  6. 6.
    Weissberger AJ, Ho KKY, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 1991;72:374–81.PubMedCrossRefGoogle Scholar
  7. 7.
    Slowinska-Srzednicka J, Zgliczynski S, Chotkowska E, Srzednicki M, Stopinska-Gluszak U, Jeske W, et al. Effects of transdermal 17-beta-oestradiol combined with oral progestogen on lipids and lipoproteins in hypercholesterolaemic postmenopausal women. J Intern Med 1993;234:447–51.PubMedCrossRefGoogle Scholar
  8. 8.
    Bellantoni MF, Harman SM, Cho DE, Blackman MR. Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages. J Clin Endocrinol Metab 1991;72:172–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Bellantoni MF, Vittone J, Campfield AT, Bass KM, Harman SM, Blackman MR. Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor I axis in younger and older postmenopausal women: a clinical research center study. J Clin Endocrinol Metab 1996;81:2848–53.PubMedCrossRefGoogle Scholar
  10. 10.
    Friend KE, Hartman ML, Pezzoli SS, Clasey JL, Thorner MO. Both oral and transdermal estrogen increase growth hormone release in postmenopausal women— a clinical research center study. J Clin Endocrinol Metab 1996;81:2250–6.PubMedCrossRefGoogle Scholar
  11. 11.
    Dell’Aglio E, Valenti G, Hoffman AR, Zuccarelli A, Passari G, Ceda GP. Lack of effect of transdermal estrogen on the growth hormone-insulin-like growth factor axis. Horm Metab Res 1994;26:211–2.CrossRefGoogle Scholar
  12. 12.
    Ma ZQ, Santagati S, Patrone C, Pollio G, Vegeto E, Maggi A. Insulin-like growth factors activate estrogen receptor to control growth and differentiation of the human neuroblastoma cell line SK-ER3. Mol Endocrinol 1994;8:910–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Gian Paolo Ceda
  • Giorgio Valenti
  • Andrew R. Hoffman

There are no affiliations available

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