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Comparision of Treatments for Otitis Media Using Multiple Diagnostic Methods

  • Chap T. Le
  • Erin M. Conlon
  • Bruce R. Lindgren
Part of the The IMA Volumes in Mathematics and its Applications book series (IMA, volume 114)

Abstract

A study of otitis media is described which requires a special method for treatment comparision because of the lack of a gold standard for disease assessment. In this paper, we investigate the use of two diagnostic procedures to estimate and to test the treatment difference; a byproduct of this maximum likelihood-based procedure is the estimates of sensitivity and specificity of each diagnostic procedure involved. We also investigate, by simulation, the power of the proposed procedure.

Key words

Treatment difference multiple diagnostic methods sensitivity specificity 

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References

  1. [1]
    Howie, V. M. and Schwartz R. H., (1983), Acute otitis media: One year in general pediatric practice, American Journal of Diseases in Children, 137, 155–158.Google Scholar
  2. [2]
    Teele, D. W., Klein, J. O., Rosner, B. et al., (1989), Epidemiology of otitis media during the first seven years of life in children in Greater Boston: A prospective cohort study, Journal of Infectious Diseases, 160, 89–94.CrossRefGoogle Scholar
  3. [3]
    Giebink, G. S., Batalden, P. B., Le, C. T., et al., (1990), A controlled trial comparing three treatments for chronic otitis media with effusion, Journal of Pediatric Infectious Diseases, 9, 33–40.CrossRefGoogle Scholar
  4. [4]
    Daly, K. A., Giebink, G. S., Anderson, R. S., et al., (1991), Resolution of otitis media with effusion with the use of a stepped treatment regimen of trimethoprim-sulfamethoæazole and prednisone, Journal of Pediatric Infectioud Diseases, 10, 500–506.CrossRefGoogle Scholar
  5. [5]
    Le, C. T., Daly, K. A., Margolis, R. H., et al., (1992), A clinical profile of otitis media, Archives of Otolaryngology, 118, 1225–1228.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Chap T. Le
    • 1
  • Erin M. Conlon
    • 1
  • Bruce R. Lindgren
    • 1
  1. 1.Division of BiostatisticsUniversity of MinnesotaMinneapolisUSA

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