Abstract
In this study we review a mathematical model for estimating the free energies of binding for γ-aminobutyric-acid-linked polyamides containing N-methylimidazole and N-methylpyrrole to five-and six-base-pair DNA sequences. We use the model to evaluate numerically several different conflicting design criteria, each characterizing the suitability of a polyamide as a chemotherapeutic agent, and we analyze the trade-offs existing between these criteria. This preliminary analysis presents several methodological and modeling problems in the area of multiobjective optimization. We introduce some concepts from multiobjective optimization and conclude by discussing the application of these concepts to solving these problems.
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Walker, W.L., Goodsell, D.S., Dickerson, R.E., Landaw, E.M. (1999). A Preliminary Multiobjective Analysis of the Chemotherapeutic Benefits of Hairpin-Linked Polyamides. In: Truhlar, D.G., Howe, W.J., Hopfinger, A.J., Blaney, J., Dammkoehler, R.A. (eds) Rational Drug Design. The IMA Volumes in Mathematics and its Applications, vol 108. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1480-9_7
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DOI: https://doi.org/10.1007/978-1-4612-1480-9_7
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