Abstract
In the seminal manuscript by Crohn, Ginsburg, and Oppenheimer in 1932 hemorrhage was not emphasized as a manifestation of “regional enteritis.” The authors noted, however, that “the stools constantly contain occult blood,” and “anemia which ordinarily is moderate may progress to a severe degree” (1). The following year a sequel entitled “Non-specific Granulomata of the intestine” was coauthored by Ginzburg and Oppenheimer (2). In a section on “Hypertrophic Colitis” they described 12 patients with segmentai colonic disease; 5 in the cecum and ascending colon, and 7 in the region of the sigmoid, in whom overt bleeding was a prominent feature. These lesions were characterized by “large irregular ulcerated areas (geographic ulcers), bullous polypoid mucosa, thickened and edematous submucosa, and hypertrophy of serosal fat both in the colon and mesocolon,” all classic features of “Crohn’s disease.”
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References
Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis. JAMA 1932;99:1323–1328.
Ginzburg L, Oppenheimer GD. Non-specific granulomata of the intestines (inflammatory tumors and strictures of the intestines). Ann Surg 1933;98:1046–1062.
Janowitz HD, Linder AE, Marshak RH. Granulomatous colitis. JAMA 1965;191:825–828.
Schofield PF, Fox H. The diagnosis of Crohn’s disease of the colon. A clinicopathological study. Br J Surgery 1969;54:307–311.
Lockhart-Mummery HE, Morson BC. Crohn’s disease of the large intestine. Gut 1964;5:439–509.
Farmer RG, Hawk WA, Turnbull RB. Regional enteritis of the colon: a clinical study pathological comparison with ulcerative colitis. Am J Dig Dis 1968; 13:501–551.
Greenstein AJ, Kark AE, Dreiling DA. Crohn’s disease of the colon. II. Controversial aspect of hemorrhage, anemia and rectal involvement in granulomatous disease involving the colon. Am J Gastroenterol 1975;63:40–48.
Yuan JG, Sachar DB, Koganei R, et al. Enterolithiasis, refractory anemia, and strictures of Crohn’s diseases. J Clin Gastroenterol 1994;18:105–108.
Robert RJ, Sachar DB, Greenstein AJ. Severe gastrointestinal hemorrhage in Crohn’s disease. Ann Surg 1991;213:207–211.
Warren R, Miller RH. Regional enteritis. N Engl J Med 1942;228:589–593.
Farmer RG, Hawk WA, Turnbull RB. Indication for surgery in Crohn’s disease. Analysis of 500 cases. Gastroenterology 1976;71:245–250.
Van Patter WN, Bargen JA, Dockerty MB, et al. Regional enteritis. Gastroenterology 1954;25:347–450.
Daffner JE, Brown CH. Regional enteritis. I. Clinical aspects and diagnosis in 100 patients. Ann Int Med 1958;49:580–594.
Sparberg M, Kirsner JB. Recurrent hemorrhage in regional enteritis. Report of 3 cases. Am J Dig Dis 1966;2:652–657.
Robert HJ, Sachar DB, Aufses AH Jr, et al. Management of severe hemorrhage in ulcerative colitis. Am J Surg 1990;159:550–555.
Cicarelli O, Coley GM. Massive rectal bleeding in Crohn’s colitis. Conn Med 1986;50:301–303.
Bruyns E, Lubbers EJC, van Tongeren JHM. Major hemorrhage in Crohn’s disease. Neth J Med 1979;22:67–71.
Jaffe BF, Youker JE, Margulis AR. Aortographic localization of controlled gastrointestinal hemorrhage in dogs. Surgery 1965;58:984–988.
Margulis AR, Heinbecker P, Bernard HR. Operative mesenteric arteriography in the search for the site of bleeding in unexplained gastrointestinal hemorrhage. Surgery 1960;48:534–539.
Nusbaum M, Baum S. Radiographic demonstration of unknown sites of gastrointestinal bleeding. Surg Forum 1963;14:374–375.
Browder W, Cerise EJ, Litwin MS. Impact of emergency angiography in massive lower gastrointestinal bleeding. Ann Surg 1986;204:530–536.
Orecchia PM, Hensley EK, McDonald PT, et al. Localization of lower gastrointestinal hemorrhage: experience with red blood cells labeled in vitro with technetium Tc 99m. Arch Surg 1985;120:521–624.
Szold A, Katz LB, Lewis BS. Surgical approach to occult gastro-intestinal bleeding. Am J Surg 1992; 163:90–93.
Lewis B, Waye J. Gastrointestinal bleeding of obscure origin: the role of small bowel enteroscopy. Gas-troenterology 1988;94:1117–1120.
Barkin J, Lewis B, Reiner D, et al. Diagnostic and therapeutic jejunoscopy with a new, longer entero-scope. Gastrointest Endos 1992;38:55–58.
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Greenstein, A.J., Heimann, T.M. (1999). Intestinal Hemorrhage. In: Michelassi, F., Milsom, J.W. (eds) Operative Strategies in Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1396-3_29
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DOI: https://doi.org/10.1007/978-1-4612-1396-3_29
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