Advertisement

The Alpha Factor

Chapter
  • 94 Downloads

Abstract

The alpha factor is a 13 amino acid peptide secreted by some cells of yeast. The yeast, Saccharomyces cerevisiae, is a eukaryote that exists either in a haploid or diploid state. It can undergo both sexual and asexual reproduction. The former occurs via the mediation of the mating of two haploid cells, types a and alpha, by two diffusible peptide pheromones, a and alpha factors. Each haploid responds to the appropriate pheromone by a series of responses such as cell-surface agglutinin synthesis, cell-cycle arrest in G1, and morphological transformation necessary for cell and nuclear fusion (1). The two types of haploids can be considered two genders since they mate. After the fusion of an a cell with an alpha cell, a zygote is formed that can propagate into a diploid line by budding or can undergo meiosis and sporulation, giving rise to a new haploid phase of the cycle (2–3).

Keywords

Alpha Factor Cyclic Peptide Alpha Cell Phospholipid Vesicle Amber Force Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Raths, S.K., Naider, F., and Becker, J.M. Journal of Biol. Chem. 263, 33, 17333 1988.Google Scholar
  2. 2.
    Naider, F., and Becker, J.M. CRC Critical Reviews in Biochemistry 21, 3, 225, 1986.PubMedCrossRefGoogle Scholar
  3. 3.
    Sprague, G.F., and Thorner, J. In The Molecular Biology of the Yeast Saccharomyces Cerevisiae, Broach, J.R., Pringle, J.R., and Jones, E.W. (eds.) 657, Cold Spring Harbor Laboratory Press, 1993.Google Scholar
  4. 4.
    Antohi, O. Ph.D. thesis, City University of New York, 1998.Google Scholar
  5. 5.
    MacKay, V., and Manney, T.R. Genetics 76, 273, 1974.PubMedGoogle Scholar
  6. 6.
    Hagen, D.C., McCaffrey, G., and Sprague, G.G. Proc. Natl. Acad. Sci. USA 83, 1418, 1986.PubMedCrossRefGoogle Scholar
  7. 7.
    Godchaux, W, and Zimmerman, W.F. J. Biol. Chem. 254, 7874, 1979.PubMedGoogle Scholar
  8. 8.
    Moscona-Amir, E., Henis, Y.I., Yechiel, E., Barenholz, Y., and Sokolovski, M. Biochemistry25, 8118, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    Higashijima, T., Fujimura, K., Masui, Y., Sakakibara, S., and Miyazawa, T. FEBS Lett. 159, 229, 1983.CrossRefGoogle Scholar
  10. 10.
    Jelicks, L.A., Shenbagamurthi, P., Becker, J.M., Naider, F., and Broido, M.S. Biopolymers 27, 431, 1988.PubMedCrossRefGoogle Scholar
  11. 11.
    Hagashijima, T., Masui, Y., Chino, N., Sakakibara, S., Kito, H., and Miyasawa, T. Eur. J. Biochem. 140, 163, 1984.CrossRefGoogle Scholar
  12. 12.
    Jelicks, L.A., Broido, M.S., Becker, J.M., and Naider, F. Biochemistry 28, 4233, 1989.PubMedCrossRefGoogle Scholar
  13. 13.
    Naider, F., Jelicks, L.A., Becker, J.M., and Broido, M.S. Biopolymers 28, 487, 1989.PubMedCrossRefGoogle Scholar
  14. 14.
    Wakamatsu, K., Okada, A., Suzuki, M., Higashijima, T., Masui, Y., Sakakibara, S., and Miyazawa, T. Eur. J. Biochem. 154, 607, 1986.PubMedCrossRefGoogle Scholar
  15. 15.
    Xue, C.B., Erotou-Bargiota, E., Miller, D., Becker, J.M., and Naider, E J. Biol. Chem. 264, 15, 19161, 1989.PubMedGoogle Scholar
  16. 16.
    Masui, Y., Tanaka, T., Chino, N., Kita, H., and Sakakibara, S. Biochem. Biophys. Res. Commun. 86, 982, 1979.PubMedCrossRefGoogle Scholar
  17. 17.
    Matsui, Y., Chino, N., Sakakibara, S., Tanaka, K., Muramaki, T., and Kita, H. Biochem. Biophys. Res. Commun. 78, 534, 1977.CrossRefGoogle Scholar
  18. 18.
    Levin, Y., Khare, R.K., Abel, G., Hill, D., Eriotou-Bargiota, E., Becker, J.M., and Naider, E Biochemistry 32, 8199, 1993.PubMedCrossRefGoogle Scholar
  19. 19.
    Bargiota, E.E., Xue, C.B., Naider, E, and Becker, J.M. Biochemistry 31, 551, 1992.CrossRefGoogle Scholar
  20. 20.
    Higashimjima, T., Miyazawa, T., Masui, Y., Chino, N., Sakakibara, S., and Kito, H. In Peptide Chemistry, Yonehara, H., ed. Protein Research Foundation, Osaka, 155,1980.Google Scholar
  21. 21.
    Garcia-Echeverria, C., Siligardi, G., Mascagani, E, Gibbons, W., Girald, E., and Pons, M. Biopolymers 31, 835, 1991.PubMedCrossRefGoogle Scholar
  22. 22.
    Gounarides, J.S., Xue, C.B., Becker, J.M., and Naider, E Biopolymers 34, 709, 1994.PubMedCrossRefGoogle Scholar
  23. 23.
    Weiner, Si., Kollman, P.A., Nguyen, D.T., and Case, D.A. J. Comp. Chem.7, 230, 1986.CrossRefGoogle Scholar
  24. 24.
    Press, W.H., Flannery, B.P., Teulolsky, S.A., and Veterling, W.T. In Numerical Recipies in C, The Art of Scientific Computing, Cambridge University Press, New York, 301, 1988.Google Scholar
  25. 25.
    Garbow, J.R., Breslav, M., Antohi, O., and Naider, E Biochemistry33, 10094, 1994.PubMedCrossRefGoogle Scholar
  26. 26.
    Gullion, T., and Schaefer, J. J. Mag. Reson. 81, 196, 1989.Google Scholar
  27. 27.
    Gullion, T., and Schaefer, J. Adv. Mag. Reson. 13, 57, 1989.Google Scholar
  28. 28.
    Garbow, J.R., and McWherter, C.A. J. Am. Chem. Soc. 115, 238,1993.CrossRefGoogle Scholar
  29. 29.
    Hing, A.W., and Schaefer, J. Biochemistry 32, 7593,1993.PubMedCrossRefGoogle Scholar
  30. 30.
    Marepalli, H.R., Antohi, O., Becker, J.M., and Naider, E J. Am. Chem. Soc. 118, 28, 6531, 1996.CrossRefGoogle Scholar
  31. 31.
    Bitar, K.G., Somogyvari-Vigh, A., and Coy, D.H. Peptides 15, 461, 1994.PubMedCrossRefGoogle Scholar
  32. 32.
    Farlie, D.P., Abbenate, G., and March, D.R. Curr. Med. Chem. 2, 654, 1995.Google Scholar
  33. 33.
    Arttamangkul, S., Murray, T.E, Delander, G.E., and Aldrich, J.V. J. Med. Chem. 38, 2410, 1995.PubMedCrossRefGoogle Scholar
  34. 34.
    Bankowsli, K., Manning, M., Seto, J., Haldar, J., and Sawyer, W.H. Int. J. Pep. Res. 16, 382, 1980.CrossRefGoogle Scholar
  35. 35.
    Sawyer, T.K., Hruby, V.J., Darman, P.A., and Hadley, M.E. Proc. Natl. Acad. Sci. USA 79, 1751, 1982.PubMedCrossRefGoogle Scholar
  36. 36.
    Mierke, D.F., Schiller, P.W., and Goodman, M. Biopolymers 29, 943, 1990.PubMedCrossRefGoogle Scholar
  37. 37.
    Fry, D.C., Madison, V.S., Greeley, D.N., Felix, A.M., Heimer, E.P., Frohman, L., Campbell, R.M., Mowels, T.E, Toome, V., and Wegrzynski, B.B. Biopolymers 32, 649, 1992.PubMedCrossRefGoogle Scholar
  38. 38.
    Kapurniotu, A., and Taylor, J.W. J. Med. Chem.38, 836, 1995.PubMedCrossRefGoogle Scholar
  39. 39.
    Charpenteir, B., Dor, A., England, P., Pham, H., Durieux, C., and Roques, B.P. J. Med. Chem. 32,1184,1989.CrossRefGoogle Scholar
  40. 40.
    Ning, Q., Ripoll, D.R., Szewczuk, Z., Konishi, Y., and Ni, F. Biopolymers 34, 1125, 1994.PubMedCrossRefGoogle Scholar
  41. 41.
    Yang, W., McKinney, A., Becker, J.W., and Naider, E. Biochemistry 34, 1308, 1995.PubMedCrossRefGoogle Scholar
  42. 42.
    Marepalli, H.R., Yang, W., Joshua, H., Becker, J.M., and Naider, E Int. J. Pep. Prot. Res. 45, 418, 1995.Google Scholar
  43. 43.
    Houston, M.E.Jr., Gannon, C.L., Kay, C.M., and Hodges, R.S. J. Pept. Sci. 1, 274, 1995.PubMedCrossRefGoogle Scholar
  44. 44.
    Antohi, O., Marepalli, H.R., Yang, W., Becker, J.M., and Naider, F. Biopolymers 45, 21, 1998.PubMedCrossRefGoogle Scholar
  45. 45.
    Shenbagamurthi, E, Kundu, B., Raths, S.K., Becker, J.M., and Naider, E Biochemistry 24, 7070, 1985.CrossRefGoogle Scholar
  46. 46.
    Naider, F., Gounarides, J., Xue, C.B., Bargiota, E., and Becker, J.M. Biopolymers 32, 335, 1992.PubMedCrossRefGoogle Scholar
  47. 47.
    Gounarides, J.S., Broido, M.S., Becker, J.M., and Naider, F.R. Biochemistry 32, 908, 1993.PubMedCrossRefGoogle Scholar
  48. 48.
    Gounarides, J.S. Ph.D. thesis, City University of New York, 1993.Google Scholar
  49. 49.
    Richardson, J.S., and Richardson, D.C. In Prediction of Protein Structure and the Principles of Protein Conformation, Plenum Press, Fasman, G.D., ed. New York, 1990.Google Scholar
  50. 50.
    Antohi, O., Naider, E, and Sapse, A.M. THEOCHEM 360, 99, 1996.CrossRefGoogle Scholar
  51. 51.
    Antohi, O., and Sapse, A.M. THEOCHEM 430, 247, 1998.CrossRefGoogle Scholar
  52. 52.
    Beachy, M.D., Chasman, D., Murphy, R.B., Halgren, T.A., and Friesner, R.A. J. Am. Chem. Soc. 119, 5908, 1996.CrossRefGoogle Scholar
  53. 53.
    Frey, R.F., Coffin, J., Newton, S.Q., Ramek, M., Cheng, V.K.W., Momany, F.A., and Schafer, L. J. Am. Chem. Soc. 114, 5369, 1992.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  1. 1.John Jay College and Graduate SchoolCity University of New YorkNew YorkUSA
  2. 2.Rockefeller UniversityNew YorkUSA

Personalised recommendations