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Molecular Orbital Calculations for Amino Acids and Peptides pp 83–96Cite as

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Ab Initio Calculations Related to Glucagon

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Abstract

Glucagon is a polypeptide (29 residues) hormone that regulates gluconeogenesis and glycogenesis in the liver. Its effects are mediated by cAMP (cyclic adenosine monophosphate), which is synthesized in a reaction catalyzed by membrane-bound adenylate cyclase. As discovered by Earl Sutherland in the 1950s, glucagon binds to receptors on the surface of liver cells, and there they trigger the formation of cAMP. While the hormone itself is thought not to penetrate the cell, cAMP mediates the intracellular effects, serving thus as a second messenger to the hormone, which is the first messenger.

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References

  1. Stryer, L. Biochemistry, 4th ed. W.H. Freeman and Co., New York, 1995.

    Google Scholar 

  2. Unson, C.G., Gurzenda, E.M., Iwasa, K., and Merrifield, R.B. Journal of Biol. Chem. 264, 2, 789, 1989.

    CAS  Google Scholar 

  3. Sasaki, K., Dockerill, S., Adamiak, D.A., Tickle, I.J., and Blundell, T. Nature 257, 751, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Chou, P.Y., and Fassman, G.D. Adv. Enzymol.2, 45, 1978.

    Google Scholar 

  5. Chou, P.Y., and Fassman, G.D. Biochemistry 14, 2536, 1975.

    Article  PubMed  CAS  Google Scholar 

  6. Unson, C.G., Andreu, D., Gurzenda, E.M., and Merrifield, R.B. Proc. Natl. Acad. Sci. USA 84, 4083, 1987.

    Article  PubMed  CAS  Google Scholar 

  7. Andreu, D., and Merrifield, R.B. In Peptides: Structure and Function, Deber, C.M., Hruby, V.J., and Kopple, K.D. (eds.) Pierce Chem. Co., Rockford, IL, 595, 1985.

    Google Scholar 

  8. Andreu, D., and Merrifield, R.B. Eur. J. Biochem. 164, 585, 1987.

    Article  PubMed  CAS  Google Scholar 

  9. Wakelam, M.J.O, Murphy, G.S., Hruby, V.J., and Houslay, M.D. Nature 323, 68, 1986.

    Article  PubMed  CAS  Google Scholar 

  10. Trimble, E.R., Bruzzone, R., Bidin,T.J., Meehan, C.J.,Andreu, D., and Merrifield, R.B. Proc. Natl. Acad. Sci. USA 84, 3146, 1987.

    Article  PubMed  CAS  Google Scholar 

  11. Stewart, J.M., York, E.J., Baldwin, R.L., and Shoemaker, K.R. 19th European Peptide Symposium 1986, Porto Carras, Greece (abs.).

    Google Scholar 

  12. Lu, G.S., Mojsov, S., and Merrifield, R.B. Int. J. Pept. Prot. Res. 29, 545, 1987.

    Article  CAS  Google Scholar 

  13. Korn, A.P., and Ottensmayer, F.P. J. Theor. Biol. 105, 403, 1983.

    Article  PubMed  CAS  Google Scholar 

  14. Chung, F.Z., Wang, C.D., Potter, P.C., Venter, J.C., and Frase, C.M. J. Biol. Chem. 263, 4052, 1988.

    PubMed  CAS  Google Scholar 

  15. Gronenborn, A.M., Boverman, G., and Core, G.M. FEBS Lett. 215, 88, 1988.

    Article  Google Scholar 

  16. Unson, C.G., Macdonald, D., and Merriefield, R.B. Arch. Biochem. Biophys. 300, 747, 1993.

    Article  PubMed  CAS  Google Scholar 

  17. Merriefield, R.B., and Unson, C.G. Peptides Proc. Chinese Peptide Symp., Hangzhou, China 251,1993.

    Google Scholar 

  18. Unson, C.G., and Merrifield, R.B. Proc. Natl. Acad. Sci. USA 92, 454, 1994.

    Article  Google Scholar 

  19. Schrag, J.D., Li, Y., Wu, S., and Cygler, M. Nature 351, 761, 1991.

    Article  PubMed  CAS  Google Scholar 

  20. Post, S.R., Rubinstein, P.G., and Tager, H.S. Proc. Natl. Acad. Sci. USA 90, 1662, 1993.

    Article  PubMed  CAS  Google Scholar 

  21. Berstein, F.C., Koetzle, T.F., Williams, G.J.B., Meyer, E.F.Jr., Brice, M.D., Rogers, J.R., Kennard, O., Shimanouchi, T., and Tasumi, M. The protein data bank. J. Mol. Biol. 112, 535, 1977.

    Article  Google Scholar 

  22. Cramer, C.J., and Truhlar, D.J. AMSOL Program 606, QCPE. Indiana Univ. Bloomington, Indiana, 1992.

    Google Scholar 

  23. Carruthers, C.J.L., Unson, C.G., Kim, H.N., and Sakmar, T.P. J. Biol. Chem. 269, 18, 29321, 1994.

    PubMed  CAS  Google Scholar 

  24. Jelinek, L.J., Lok, S., Rosenberge, G.B., Smith, R.A., Grant, F.J., Biggs, S., Bensch, RA., Kuijper, J.L., Sheppard, P.O., Sprecher, C.A., O’Hara, PJ., Foster, D., Walker, K.M., Chen, L.H.J., McKernan, P.A., and Kindsvogel, W. Science 259, 1614, 1993.

    Article  PubMed  CAS  Google Scholar 

  25. Iwanji, V., and Vincent, A.C. J. Biol. Chem. 265, 2 1302, 1990.

    Google Scholar 

  26. Unson, C.G., and Merrifield, R.B. Proc. Natl. Acad. Sci. USA, 91, 454, 1994.

    Article  PubMed  CAS  Google Scholar 

  27. Wright, D.E., and Rodbell, M. J. Biol. Chem. 254, 268, 1979.

    PubMed  CAS  Google Scholar 

  28. Iyengar, R., and Herberg, J.T. J. BioL Chem. 259, 5222, 1983.

    Google Scholar 

  29. Unson, C.G., Wu, C.R., and Merrifield, R.B. Biochemistry 33, 6884, 1994.

    Article  PubMed  CAS  Google Scholar 

  30. Unson, C.G., Cypress, A.M., Wu, C.R., Goldsmith, P.K., Merrifield, R.B., and Sakman, T.P Proc. Natl. Acad. Sci. USA V93, P 310, 1996.

    Article  Google Scholar 

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Authors and Affiliations

  1. John Jay College and Graduate School, City University of New York, New York, NY, 10019, USA

    Anne-Marie Sapse

  2. Rockefeller University, New York, NY, 10021, USA

    Anne-Marie Sapse

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  1. Anne-Marie Sapse
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© 2000 Springer Science+Business Media New York

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Sapse, AM. (2000). Ab Initio Calculations Related to Glucagon. In: Molecular Orbital Calculations for Amino Acids and Peptides. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1354-3_8

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  • DOI: https://doi.org/10.1007/978-1-4612-1354-3_8

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-7109-3

  • Online ISBN: 978-1-4612-1354-3

  • eBook Packages: Springer Book Archive

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