Ab Initio Calculations Related to Glucagon



Glucagon is a polypeptide (29 residues) hormone that regulates gluconeogenesis and glycogenesis in the liver. Its effects are mediated by cAMP (cyclic adenosine monophosphate), which is synthesized in a reaction catalyzed by membrane-bound adenylate cyclase. As discovered by Earl Sutherland in the 1950s, glucagon binds to receptors on the surface of liver cells, and there they trigger the formation of cAMP. While the hormone itself is thought not to penetrate the cell, cAMP mediates the intracellular effects, serving thus as a second messenger to the hormone, which is the first messenger.


Adenylate Cyclase Activity Aspartic Residue Glutamic Residue Glucagon Receptor Inhibition Index 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  1. 1.John Jay College and Graduate SchoolCity University of New YorkNew YorkUSA
  2. 2.Rockefeller UniversityNew YorkUSA

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