Abstract
Glucagon is a polypeptide (29 residues) hormone that regulates gluconeogenesis and glycogenesis in the liver. Its effects are mediated by cAMP (cyclic adenosine monophosphate), which is synthesized in a reaction catalyzed by membrane-bound adenylate cyclase. As discovered by Earl Sutherland in the 1950s, glucagon binds to receptors on the surface of liver cells, and there they trigger the formation of cAMP. While the hormone itself is thought not to penetrate the cell, cAMP mediates the intracellular effects, serving thus as a second messenger to the hormone, which is the first messenger.
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Sapse, AM. (2000). Ab Initio Calculations Related to Glucagon. In: Molecular Orbital Calculations for Amino Acids and Peptides. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1354-3_8
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DOI: https://doi.org/10.1007/978-1-4612-1354-3_8
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