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Nitric Oxide and Peripheral Neurotransmission in the Lung

  • Chapter
Nitric Oxide and Free Radicals in Peripheral Neurotransmission

Part of the book series: Nitric Oxide in Biology and Medicine ((NOBM,volume 2))

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Abstract

Nerves regulate several aspects of airway function (Barnes, 1992). However, for the purposes of this chapter, I will focus on the role of nitric oxide (NO)-containing nerves in the control of airway smooth muscle function. Neural control of airway smooth muscle is very complex, since in addition to cholinergic and adrenergic innervation there is a nonadrenergic, noncholinergic (NANC) innervation. The existence of a NANC nervous system in the gastrointestinal tract, which controls gut motility, sphincters, and secretions, had previously been established in vertebrates from fish to humans (Burnstock,1972). The airways develop embryologically from the foregut, and so the existence of NANC nerves in the respiratory tract was not an unexpected finding.

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  1. Maria G. Belvisi
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  1. Department of Physiology and Pharmacology The Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY, 10031, USA

    Stanley Kalsner Ph.D.

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Belvisi, M.G. (2000). Nitric Oxide and Peripheral Neurotransmission in the Lung. In: Kalsner, S. (eds) Nitric Oxide and Free Radicals in Peripheral Neurotransmission. Nitric Oxide in Biology and Medicine, vol 2. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1328-4_6

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