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Nitric Oxide and Hypertension

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Nitric Oxide and the Regulation of the Peripheral Circulation

Part of the book series: Nitric Oxide in Biology and Medicine ((NOBM,volume 1))

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Abstract

Since the pioneering work of Furchgott and Zawadzki (1980), it has become increasingly clear that the vascular endothelium plays a key role in the regulation of the cardiovascular system. The discovery in 1987 that nitric oxide (NO) accounts for the vasorelaxing action of the endothelium (Ignarro et al. 1987; Palmer et al. 1987), opening the possibility of specifically inhibiting NO synthesis, greatly enlarged our understanding of endothelial physiology and gave rise to a vast new area of biological knowledge: NO physiology.

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Authors
  1. Roberto Zatz
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  2. Christine Baylis
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Editors and Affiliations

  1. Department of Pharmacology, Tulane University Medical Center, New Orleans, LA, 70112-2699, USA

    Philip J. Kadowitz Ph.D.  & Dennis B. McNamara Ph.D.  & 

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Zatz, R., Baylis, C. (2000). Nitric Oxide and Hypertension. In: Kadowitz, P.J., McNamara, D.B. (eds) Nitric Oxide and the Regulation of the Peripheral Circulation. Nitric Oxide in Biology and Medicine, vol 1. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1326-0_7

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  • DOI: https://doi.org/10.1007/978-1-4612-1326-0_7

  • Publisher Name: Birkhäuser, Boston, MA

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