Nitric Oxide and Hypertension

  • Roberto Zatz
  • Christine Baylis
Part of the Nitric Oxide in Biology and Medicine book series (NOBM, volume 1)


Since the pioneering work of Furchgott and Zawadzki (1980), it has become increasingly clear that the vascular endothelium plays a key role in the regulation of the cardiovascular system. The discovery in 1987 that nitric oxide (NO) accounts for the vasorelaxing action of the endothelium (Ignarro et al. 1987; Palmer et al. 1987), opening the possibility of specifically inhibiting NO synthesis, greatly enlarged our understanding of endothelial physiology and gave rise to a vast new area of biological knowledge: NO physiology.


Nitric Oxide Nitric Oxide Synthesis Losartan Potassium Renal Sympathetic Nerve Activity Renal Nerve 
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© Springer Science+Business Media New York 2000

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  • Roberto Zatz
  • Christine Baylis

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