Role of Nitric Oxide in the Regulation of Renal Blood Flow

  • Dewan S. A. Majid
  • L. Gabriel Navar
Part of the Nitric Oxide in Biology and Medicine book series (NOBM, volume 1)


The regulation of renal blood flow is of vital importance to the overall control of renal function and, thus, to the maintenance of body fluid and electrolyte homeostasis. Among the many factors regulating blood flow to the kidney, the contributing roles of various intrarenal paracrine systems and their complex interactions are of paramount importance (Navar et al. 1996). Over the past decade, an enormous amount of research has established nitric oxide (NO) as an important regulator of renal hemodynamics and excretory function (Navar et al. 1996; Kone and Baylis 1997; Majid and Navar 1997; Mattson et al. 1997). In the kidney, NO interacts with vascular smooth muscle and with mesangial, juxtaglomerular, and tubular cells to profoundly affect vascular and tubular function (Navar et al. 1996; Kone and Baylis 1997). In this chapter, we have focused on the importance of intrarenal NO in the regulation of renal vascular resistance and its influence on the renal autoregulatory mechanism. In addition to the direct effects of NO, we also discuss the various interactions of NO with other renal paracrine factors.


Nitric Oxide Renal Blood Flow Renal Vascular Resistance Efferent Arteriole Cortical Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Dewan S. A. Majid
  • L. Gabriel Navar

There are no affiliations available

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