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Role of Nitric Oxide in the Regulation of Renal Blood Flow

  • Chapter
Nitric Oxide and the Regulation of the Peripheral Circulation

Part of the book series: Nitric Oxide in Biology and Medicine ((NOBM,volume 1))

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Abstract

The regulation of renal blood flow is of vital importance to the overall control of renal function and, thus, to the maintenance of body fluid and electrolyte homeostasis. Among the many factors regulating blood flow to the kidney, the contributing roles of various intrarenal paracrine systems and their complex interactions are of paramount importance (Navar et al. 1996). Over the past decade, an enormous amount of research has established nitric oxide (NO) as an important regulator of renal hemodynamics and excretory function (Navar et al. 1996; Kone and Baylis 1997; Majid and Navar 1997; Mattson et al. 1997). In the kidney, NO interacts with vascular smooth muscle and with mesangial, juxtaglomerular, and tubular cells to profoundly affect vascular and tubular function (Navar et al. 1996; Kone and Baylis 1997). In this chapter, we have focused on the importance of intrarenal NO in the regulation of renal vascular resistance and its influence on the renal autoregulatory mechanism. In addition to the direct effects of NO, we also discuss the various interactions of NO with other renal paracrine factors.

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Authors
  1. Dewan S. A. Majid
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  2. L. Gabriel Navar
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Editors and Affiliations

  1. Department of Pharmacology, Tulane University Medical Center, New Orleans, LA, 70112-2699, USA

    Philip J. Kadowitz Ph.D.  & Dennis B. McNamara Ph.D.  & 

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Majid, D.S.A., Navar, L.G. (2000). Role of Nitric Oxide in the Regulation of Renal Blood Flow. In: Kadowitz, P.J., McNamara, D.B. (eds) Nitric Oxide and the Regulation of the Peripheral Circulation. Nitric Oxide in Biology and Medicine, vol 1. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1326-0_19

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  • DOI: https://doi.org/10.1007/978-1-4612-1326-0_19

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