Human Alveolar Long-Term Clearance in Healthy and Disease Evaluated by Magnetopneumography
Magnetopneumography (MPG) was used to investigate alveolar long-term clearance of the human lungs in healthy and disease. Further investigations have shown that this method can be used to record alveolar clearance of the human lungs non-invasively over a period of more than one year [1, 2]. The method of magnetopneumography prevents ethical objections when doing the investigations on humans. Another method for the investigation of alveolar clearance is the radioactive labeling technique. But radionuclides with long half-lives (≈0.5 year) are necessary for alveolar clearance studies. Therefore the radioactive labeling technique is only applicable in animal studies. Further studies have shown that alveolar clearance might be impaired by cigarette smoking. Therefore the data were analyzed with respect to smoking conditions. Additionally patients with chronic obstructive lung disease (COPD), sarcoidosis (SARK) and idiopathic lung fibrosis (FIBR) were investigated. This study gives new information on disturbed alveolar defense mechanisms, that might be a co-factor in the formation of the disease.
KeywordsChronic Obstructive Pulmonary Disease Human Lung Chronic Obstructive Lung Disease Bronchial Obstruction Slow Clearance
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