Standard Multiple Compartment Analysis with the Deterministic Model

  • James H. Matis
  • Thomas R. Kiffe
Part of the Lecture Notes in Statistics book series (LNS, volume 145)


Compartmental modeling is widely used in pharmacokinetics and in physiological modeling, for which there is a vast literature. In addition to Jacquez [28], leading texts include [3, 22, 85]. As a simple example, the mercury bioaccumulation problem in Section 4.2.2 illustrates the need for a multi-compartment analysis. The techniques have also been applied to ecosystem modeling (see e.g. [52]).


Mercury Librium Bioaccumulation 


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Copyright information

© Springer-Verlag New York, Inc. 2000

Authors and Affiliations

  • James H. Matis
    • 1
  • Thomas R. Kiffe
    • 2
  1. 1.Department of StatisticsTexas A&M UniversityCollege StationUSA
  2. 2.Department of MathematicsTexas A&M UniversityCollege StationUSA

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