Abstract
This chapter reviews the efficacy of treatment for childhood growth hormone (GH) deficiency in the context of the natural history of the condition. Data on the effects of GH therapy on the multidimensional morbidity of GH deficiency will be discussed, and emerging innovations in treatment of childhood GH deficiency will be reviewed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gilford H. Ateliosis: a form of dwarfism. Practitioner 1903; 70: 797–819.
Wit JM, Kamp GA, Rikken B. Spontaneous growth and response to growth hormone treatment in children with growth hormone deficiency and idiopathic short stature. Pediatr Res 1996; 39: 295–302.
Shore RM, Chesney RW, Mazess RB, Rose PG, Bargman GJ. Bone mineral status in growth hormone deficiency. J Pediatr 1980; 96: 393–96.
Zamboni G, Antoniazzi F, Radetti G, Musumeci C, Tato L. Effect of two different regimens of recombinant human growth hormone therapyon the bone mineral density of patients with growth hormone deficiency. J Pediatr 1991; 119: 483–85.
Saggese G, Baroncelli GI, Bertelloni S, Barsanti S. The effect of long-term growth hormone (GH) treatment on bone mineral density in children with GH deficiency. Role of GH in the attainment of peak bone mass. J Clin Endocrinol Metab 1996; 81: 3077–83.
Novak LP, Hayles AB, Cloutier MD. Effect of hGH on body composition of hypo-pituitary dwarfs. Mayo Clin Proc 1972; 47: 241–46.
Parra A, Argote RM, Garcia G, Cervantes C, Alatorre S, Perez-Pasten E. Body composition in hypopituitary dwarfs before and during human growth hormone therapy. Metabolism 1979; 28: 851–57.
Stabler B, Siegel PT, Clopper RR. Growth hormone deficiency in children has psychological and educational co-morbidity. Clin Pediatrics 1991; 3: 156–60.
Drotar D, Owens R, Gotthold J. Personality adjustment of children and adolescents with hypopituitarism. Child Psych Hum Dev 1980; 11: 59–65.
Stabler B, Clopper RR, Seigel PT, Stoppani C, Compton PG, Underwood LE. Academic achievement and psychological adjustment in short children. J Dev Behav Pediatr 1994; 15: 1–6.
Dean HJ, McTaggart TL, Fish DG, Friesen HG. The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. Am J Dis Child 1985; 139: 1105–10.
Taback S, Dean HJ, and members of the Canadian growth hormone advisory committee. Mortality in Canadian children with growth hormone (GH) deficiency receiving GH therapy 1967-1992. J Clin Endocrinol Metab 1996; 81: 1693–96.
Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285–88.
Blethen SL, Compton P, Lippe BM, Rosenfeld RG, August GP, Johanson A. Factors predicting the response to growth hormone (GH) therapy in prepubertal children with GH deficiency. J Clin Endocrinol Metab 1993; 76: 574–79.
Ranke MB, Guilbaud O. Growth response in prepubertal children with idiopathic growth hormone deficiency during the first two years of treatment with human growth hormone. Analysis of the Kabi Pharmacia International Growth Study. Acta Paediatr Scand 1991; 379(suppl): 109–15.
MacGillivray MH, Baptista J, Johanson A, on behalf of the Genentech Study Group. Outcome of a four-year randomized study of daily versus three times weekly soma-totropin treatment in prepubertal naïve growth hormone-deficient children. J Clin Endocrinol Metab 1996; 81: 1806–09.
Hibi I, Tanaka T, Tanae A, Kagawa J, Hashimoto N, Yoshizawa A, et al. The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children. J Clin Endocrinol Metab 1989; 69: 221–26.
Lenko HL, Leisti S, Perheentupa J. The efficacy of growth hormone in different types of growth failure. Eur J Pediatr 1982; 138: 241–49.
Arrigo T, DeLuca F, Bernasconi S, Bozzola M, Cavallo L, Crisafulli G, et al. Catch-up growth and height prognosis in early treated children with congenital hypopituitarism. Horm Res 1995; 44(suppl): 26–31.
Bramswig JH, Schlosser H, Kiese K. Final height in children with growth hormone deficiency. Horm Res 1995; 43: 126–28.
Libber SM, Plotnick LP, Johnason AJ, Blizzard RM, Kwiterovich PO, Migeon CJ. Long-term follow-up of hypopituitary patients treated with human growth hormone. Medicine 1990; 69: 46–55.
Coste J, Letrait M, Carel JC, Tresca JP, Chatelain P, Rochiccioli P, et al. Long-term results of growth hormone treatment in France in children of short stature: population, register based study. Br Med J 1997; 315: 708–13.
Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A. On behalf of the Genentech Growth Study Group. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. J Clin Endocrinol Metab 1997; 82: 418–20.
Saggese G, Baroncelli GI. Bone and mineral density and biochemical parameters of bone turnover in children with growth hormone deficiency. Horm Res 1996; 45(suppl): 67–68.
Bonnet F, Vanderschueren-Lodeweyckx, Eeckels R, Malvaux P. Subcutaneous adipose tissue and lipids in blood in growth hormone deficiency before and after treatment with human growth hormone. Pediatr Res. 1974; 8: 800–5.
Attanasio AF, Lamberts SWJ, Matranga AMC, Birkett MA, Bates PC, Valk NK, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J Clin Endocrinol Metab 1997; 82: 82–88.
Stabler B, Clopper RR, Nicholas LM, Silva SG, Tancer ME, Underwood LE. Links between growth hormone deficiency, adaptation and social phobia. Horm Res 1996; 45: 30–33.
Blethen SL, Allen DB, Graves D, August G, Moshang T, Rosenfeld R. Safety of recombinant deoxyribonucleic acid-derived growth hormone: the National Cooperative Growth Study Experience. J Clin Endocrinol Metab 1996; 81: 1704–10.
Malazowski S, Hung W, Scott DC. Acute pancreatitis associated with growth hormone therapy for short stature. N Engl J Med 1995; 332: 401–2.
Johnson OFL, Cleland JL, Lee HJ, Charnis M, Duenas E, et al. A month-long effect from a single injection of microencapsulated human growth hormone. Nat Med 1996; 2: 795–99.
Leone-Bay A, Ho K-K, Agarwal R, Baughman RA, Chaudhary K, Demorin F, et al. 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone. J Med Chem 1996; 39: 2571–78.
Cara JF, Kreiter ML, Rosenfield RL. Height prognosis of children with true precocious puberty and growth hormone deficiency: Effect of combination therapy with gonadot-ropin releasing hormone agonist and growth hormone. J Pediatr 1992; 120: 709–15.
Adan L, Souberielle JC, Zucker JM, Pierre-Kahn A, Kalifa C, Brauner R. Adult height in 24 patients treated for growth hormone deficiency and early puberty. J Clin Endocrinol Metab 1997; 82: 229–33.
Guevara-Aguirre J, Vasconez O, Martinez V, Martinez AL, Rosenbloom AL, Diamond FB, et al. Randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-1 in children with growth hormone receptor deficiency. J Clin Endocrinol Metab 1995; 80: 1393–98.
Backeljauw PF, Underwood LE, and the GHIS collaborative group. J Clin Endocrinol Metab 1996; 81: 3312–17.
Thorner M, Rochiccioli P, Colle R, Lanes R, Grunt J, Galazka A, et al. Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. J Clin Endocrinol Metab 1996; 81: 1189–96.
Loche S, Cambiaso P, Merola B, Colao A, Faedda A, Imbibo BP. The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency. J Clin Endocrinol Metab 1995; 80: 2692–96.
Bercu BB, Yang SW, Masuda R, Walker RF. Role of selected endogenous peptides in growth hormone-releasing hexapeptide activity: analysis of growth hormone-releasing hormone, thyroid hormone-releasing hormone, and gonadotropin-releasing hormone. Endocrinology 1992; 130: 2579–86.
Mericq F, Cassorla F, Slazar T, Avila A, Iniguez G, Bowers CY, et al. Increased growth velocity during prolonged GHRP-2 administration to growth hormone deficient children. Presented at the 1997 meeting of the Endocrine Society (OR30-3) (Abstract).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media New York
About this paper
Cite this paper
Cuttler, L. (2000). Treatment of Childhood Growth Hormone Deficiency: Efficacy and Innovation. In: Stabler, B., Bercu, B.B. (eds) Therapeutic Outcome of Endocrine Disorders. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1230-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-1230-0_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7052-2
Online ISBN: 978-1-4612-1230-0
eBook Packages: Springer Book Archive