Abstract
The availability of abundant supplies of recombinant human growth (GH) has made it possible to test the effects of GH treatment on short children with diagnoses other than GH deficiency. For example, treatment of girls with Turner Syndrome and children with chronic renal failure has been observed to accelerate rates of statural growth and to increase adult height (1,2). Despite improvement over the last 30-35 years in the tools used for determining the causes of short stature, no specific diagnosis is made in a large proportion of the short children who are brought to medical attention. These children are referred to as having “normal” short stature, idiopathic short stature, or are given one of a variety of other designations (Table 10.1). The number and nature of the mechanisms involved in the slow growth and short stature of these patients is not known.
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References
Rosenfeld RG, Frane J, Attie KM, Brazel JA, Burstein S, Cara JF, et al Six year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. J Pediatr 1992; 121: 49–55.
Fine RN, Kohut E, Brown D, Kuntze J, Attie KM. Long-term treatment of growth retarded children with chronic renal insufficiency, with recombinant human growth hormone. Kidney Internat 1996; 49: 781–85.
Hopwood NJ, Hintz RL, Gertner JM, Attie KM, Johanson AJ, Baptista J, et al Growth response of children with non-growth hormone deficiency and marked short stature during 3 years of growth hormone therapy. J Pediatr 1993; 123: 215–22.
Hindmarsh PC, Brook CGD. Effect of growth hormone on short normal children. Br Med J 1987; 295: 573–77.
Wit JM, Fokker MG, deMuinck Keizer-Schrama SMPH, et al Effects of two years of methionyl growth hormone therapy in low-dosage regimens to prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. J Pediatr 1989; 115: 720–25.
Bierich JR, Nolte K, Drews K, Brugmann G. Constitutional delay of growth and adolescence. Results of short-term and long-term treatment with growth hormone. Acta Endocrinol 1992; 127: 392–96.
Albertsson-Wikland K. Characteristics of children with idiopathic short stature in the Kabi Pharmacia International Growth Study, and their response to growth hormone treatment. Acta Paediatr 1993; 391(suppl): 75–78.
Laron Z, Klinger B, Anin S, Pertzelan A, Lilos P. Growth during and 2 years after stopping GH treatment in prepubertal children with idiopathic short stature. J Ped Endocrinol Metab 1997; 10: 191–96.
Schmitt K, Blumel P, Waldhor T, Lassi M, Tulzer G, Frisch H. Short-and long-term (final height) data in children with normal variant short stature treated with growth hormone. Eur J Pediatr 1997; 156: 680–83.
Kawai M, Momio T, Yorfuji T, Yamanaka C, Sasaki H, Furusho K. Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency. J Pediatr 1997; 130: 205–9.
Loche S, Cambiaso P, Setzu S, Carta D, Marini R, Borrelli P, et al Final height after growth hormone therapy in non-growth hormone deficient children with short stature. J Pediatr 1994; 125: 196–200.
Wit JM, Boersma B, deMuinch Keizer-Schrama SMPF, Nienhuis HE, Oostdijk W, et al Long-term results of growth hormone therapy in children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. Clin Endocrinol 1995; 42: 365–72.
Hindmarsh P, Brook CGD. Final height of short normal children treated with growth hormone. Lancet 1996; 348: 13–16.
Guyda HJ. Growth hormone treatment of non-growth hormone deficient subjects: the international task force report. Clin Pediatr Endocrinol 1996; 5(suppl 7): 11–18.
Hintz RL, for U.S. Collaborative NCGS. Presented to the combined meeting of the European Society for Pediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society. Stockholm, Sweden, June 1997.
Cuttler L, Silvers JB, Singh J, Marrero U, Finklestein B, Tannin G, et al Short stature and growth hormone therapy: a national study of physician recommendation patterns. JAMA 1996; 276: 531–37.
Voss LD, Mulligan J. The short normal child in school: Self-esteem, behavior, and attainment before puberty (The Wessex Growth Study). In: Stabler B, Underwood LE, eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.
Sandberg DE, Brook AE, Campos SP. Short stature in middle childhood: a survey of psychological functioning in a clinically referred sample. In: Stabler B, Underwood LE, eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.
Vance MD, Ingersoll GM, Golden MP. Short stature in a nonclinical sample: not a big problem. In Stabler B, Underwood LE eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina 1994.
Skuse D, Gilmore J. Quality of life of children with normal short stature. Clin Pediatr Endocrinol 1997; 6(suppl 9): 29–37.
Downey AB, Mulligan J, McCaughey ES, Stratford RJ, Betts PR, Voss LD. Psychological response to growth hormone treatment in short normal children. Arch Dis Child 1996; 75: 32–35.
Lieberman E, Pilpel D, Carel CA, Levi E, Zadik Z. Coping and satisfaction with growth hormone treatment among short-stature children. Horm Res 1993; 40: 128–33.
Stabler B, Clopper RR, Siegel PT, Stoppani C, Compton PG, Underwood LE. Academic achievement and psychological adjustment in short children. J Dev Behav Pediatr 1994; 14: 1–6.
Stabler B, Siegel PT, Clopper RR, Stoppani CE, Compton PG, Underwood LE. Behavior change after growth hormone treatment of children with short stature. J Pediatr 1998; 133: 366–73.
Eminson DM, Powell RP, Hollis S. Cognitive behavioral intervention with short statured boys: apilot study. In: Stabler B, Underwood LE eds.. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.
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Underwood, L.E., Stabler, B. (2000). The Non-Growth Hormone-Deficient Child: Does Therapy with Growth Hormone Produce Benefit?. In: Stabler, B., Bercu, B.B. (eds) Therapeutic Outcome of Endocrine Disorders. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1230-0_10
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DOI: https://doi.org/10.1007/978-1-4612-1230-0_10
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